🍽️ folinic acid calcium salt,(prescription)

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  1. Treatment of Folate Deficiency: Folinic acid is used to treat folate deficiency, which can occur due to inadequate dietary intake, malabsorption disorders, certain medications, or increased demand during pregnancy or certain medical conditions.

  2. Supports DNA Synthesis and Repair: Folinic acid plays a crucial role in DNA synthesis and repair. It serves as a cofactor in various enzymatic reactions involved in the production of nucleic acids, which are essential for cell division and growth.

  3. Management of Megaloblastic Anemia: Folinic acid supplementation can help in the management of megaloblastic anemia, a condition characterized by abnormally large and immature red blood cells due to impaired DNA synthesis. Megaloblastic anemia is commonly caused by folate deficiency or vitamin B12 deficiency.

  4. Adjunct Therapy in Cancer Treatment: Folinic acid is often used as an adjunct therapy in combination with certain chemotherapy drugs, such as methotrexate. It helps reduce the toxic effects of methotrexate on normal cells by "rescuing" them from the inhibition of dihydrofolate reductase caused by methotrexate.

  5. Neurological Disorders: Folinic acid may be used as part of the treatment regimen for certain neurological disorders, including cerebral folate deficiency syndrome and autism spectrum disorders (ASD). Some studies suggest that folinic acid supplementation may improve certain neurological symptoms in these conditions.

  6. Prevention of Neural Tube Defects: Adequate folate intake, including folinic acid supplementation, is essential during pregnancy to reduce the risk of neural tube defects, such as spina bifida and anencephaly, in the developing fetus.

  7. Management of Methotrexate Toxicity: Folinic acid is also used as a rescue therapy to mitigate the toxic effects of high-dose methotrexate chemotherapy, which can lead to severe bone marrow suppression and mucositis. Folinic acid helps "rescue" normal cells from the effects of methotrexate by providing an alternative pathway for folic acid metabolism.

  8. Administration Routes: Folinic acid can be administered orally, intravenously, or intramuscularly, depending on the indication and the patient's clinical condition.

  9. Side Effects and Adverse Reactions: Folinic acid is generally well-tolerated, but some individuals may experience side effects such as nausea, vomiting, diarrhea, rash, or allergic reactions. Rarely, high doses of folinic acid may lead to electrolyte imbalances or exacerbate seizures in individuals with epilepsy.

  10. Monitoring and Dosage Adjustments: Patients receiving folinic acid therapy may require monitoring of folate levels in the blood and adjustment of dosage based on clinical response and laboratory parameters.

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Impacted of folinic acid calcium salt,(prescription) On Probiotics

Rank Probiotic Impact
species Bifidobacterium longum Reduces
species Escherichia coli Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by folinic acid calcium salt,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Phocaeicola genus Decreases 👪 Source Study
Ruminococcus genus Decreases 👪 Source Study
Coprococcus genus Decreases 👪 Source Study
Escherichia genus Decreases 👪 Source Study
Collinsella genus Decreases 👪 Source Study proinflammatory
Bifidobacterium genus Decreases 👪 Source Study
Bacteroides genus Decreases 👪 Source Study
Segatella genus Decreases 👪 Source Study
Streptococcus genus Decreases 👪 Source Study
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
unclassified Negativicoccus no rank Decreases ⚗️ Source Study
Escherichia coli O80:H26 no rank Decreases 👶 Source Study
Eggerthellales order Decreases ⚗️ Source Study
Escherichia coli O145 serogroup Decreases 👶 Source Study
Escherichia coli O157 serogroup Decreases 👶 Source Study
Escherichia coli O26 serogroup Decreases 👶 Source Study
Escherichia coli O43 serogroup Decreases 👶 Source Study
Escherichia coli O1:H42 serotype Decreases 👶 Source Study
Escherichia coli O104:H4 serotype Decreases 👶 Source Study
Escherichia coli O121:H19 serotype Decreases 👶 Source Study
Escherichia coli O127:H6 serotype Decreases 👶 Source Study
Escherichia coli O139:H28 serotype Decreases 👶 Source Study
Escherichia coli O157:H7 serotype Decreases 👶 Source Study bloody diarrhea
Escherichia coli O44:H18 serotype Decreases 👶 Source Study
Escherichia coli O55:H7 serotype Decreases 👶 Source Study
Escherichia coli O6:H16 serotype Decreases 👶 Source Study
Escherichia coli O7:K1 serotype Decreases 👶 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Negativicoccus sp. S5-A15 species Decreases ⚗️ Source Study
Phocaeicola vulgatus species Decreases 📓 Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Ruminococcus bromii species Decreases 📓 Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Coprococcus comes species Decreases 📓 Source Study
Escherichia coli species Decreases 📓 Source Study Diarrheal disease in children and travelers, Foodborne diarrhea outbreaks, hemorrhagic colitis, hemolytic-uremic syndrome
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Bacteroides fragilis species Decreases 📓 Source Study H02076 Bacteroides infection
Bacteroides ovatus species Decreases 📓 Source Study
Collinsella aerofaciens species Decreases 📓 Source Study
Bifidobacterium longum species Decreases 📓 Source Study
Segatella copri species Decreases 📓 Source Study Over 70%ile Indicator of mycotoxin present
Bacteroides thetaiotaomicron species Decreases 📓 Source Study
Streptococcus parasanguinis species Decreases 📓 Source Study
Bacteroides xylanisolvens species Decreases 📓 Source Study
Coriobacterineae suborder Decreases ⚗️ Source Study
Bifidobacterium longum subsp. infantis subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. longum subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. suillum subspecies Decreases 👶 Source Study
Chlamydiae/Verrucomicrobia group superphylum Decreases ⚗️ Source Study

Impact of folinic acid calcium salt,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Acne 0 0
ADHD 0.3 0.1 2
Allergic Rhinitis (Hay Fever) 0.1 0.1 0
Allergies 0.4 0.2 1
Allergy to milk products 0.2 0.1 1
Alopecia (Hair Loss) 0 0
Alzheimer's disease 0.3 0.3 0
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.3 0.2 0.5
Ankylosing spondylitis 0.4 0.1 3
Anorexia Nervosa 0.1 -0.1
Antiphospholipid syndrome (APS) 0.2 0.2
Asthma 0 0 0
Atherosclerosis 0.2 0.2
Atrial fibrillation 0.2 0.2 0
Autism 0.6 0.7 -0.17
Barrett esophagus cancer 0 0
benign prostatic hyperplasia 0.1 0.1
Bipolar Disorder 0.2 0.1 1
Brain Trauma 0.1 0 0
Carcinoma 0.3 0.2 0.5
Celiac Disease 0.3 0.2 0.5
Cerebral Palsy 0 0.1 0
Chronic Fatigue Syndrome 0.4 0.5 -0.25
Chronic Kidney Disease 0.1 0.1 0
Chronic Lyme 0 0
Chronic Obstructive Pulmonary Disease (COPD) 0 0.1 0
Chronic Urticaria (Hives) 0.2 0.2 0
Coagulation / Micro clot triggering bacteria 0.2 0.1 1
Colorectal Cancer 0.5 0.1 4
Constipation 0.3 0.3
Coronary artery disease 0.1 0.1 0
COVID-19 0.7 0.8 -0.14
Crohn's Disease 0.6 0.4 0.5
cystic fibrosis 0.2 0.1 1
deep vein thrombosis 0.2 0.1 1
Depression 0.7 0.6 0.17
Dermatomyositis 0 0 0
Eczema 0.1 0.2 -1
Endometriosis 0.4 0.1 3
Epilepsy 0.3 0.1 2
Fibromyalgia 0.3 -0.3
Functional constipation / chronic idiopathic constipation 0.8 0.3 1.67
gallstone disease (gsd) 0.1 0 0
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.3 0 0
Generalized anxiety disorder 0.2 0.2 0
Glioblastoma 0 0
Gout 0.1 -0.1
Graves' disease 0.1 0 0
Halitosis 0 0 0
Hashimoto's thyroiditis 0.1 0.1 0
Hidradenitis Suppurativa 0 0
Histamine Issues,Mast Cell Issue, DAO Insufficiency 0.3 0.3
hyperglycemia 0.1 0.1 0
Hyperlipidemia (High Blood Fats) 0.1 0 0
hypertension (High Blood Pressure 0.3 0.3 0
Hypothyroidism 0.1 -0.1
Hypoxia 0 0
IgA nephropathy (IgAN) 0.2 -0.2
Inflammatory Bowel Disease 0.4 0.7 -0.75
Insomnia 0 0 0
Intelligence 0.1 0.1 0
Intracranial aneurysms 0.1 0 0
Irritable Bowel Syndrome 0.4 0.3 0.33
Liver Cirrhosis 0.3 0.2 0.5
Long COVID 0.5 0.6 -0.2
Low bone mineral density 0.1 -0.1
Lung Cancer 0.1 0.1 0
ME/CFS with IBS 0 0.2 0
ME/CFS without IBS 0.1 0.1 0
Menopause 0.2 0.2
Metabolic Syndrome 0.7 0.6 0.17
Mood Disorders 0.9 0.6 0.5
multiple chemical sensitivity [MCS] 0 0
Multiple Sclerosis 0.2 0.3 -0.5
Multiple system atrophy (MSA) 0 0.1 0
Neuropathy (all types) 0 0.1 0
neuropsychiatric disorders (PANDAS, PANS) 0.1 0.1
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.2 0.3 -0.5
NonCeliac Gluten Sensitivity 0 0
Obesity 0.4 0.3 0.33
obsessive-compulsive disorder 0.8 0.2 3
Osteoarthritis 0.1 0.1 0
Osteoporosis 0.2 0 0
pancreatic cancer 0 0
Parkinson's Disease 0.3 0.3 0
Polycystic ovary syndrome 0.3 0.2 0.5
Postural orthostatic tachycardia syndrome 0.1 -0.1
Premenstrual dysphoric disorder 0.1 0.1
primary biliary cholangitis 0 0
Psoriasis 0.5 0.2 1.5
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 0.5 0.3 0.67
Rosacea 0.1 0.1
Schizophrenia 0.3 0.2 0.5
scoliosis 0.1 0.1 0
Sjögren syndrome 0.1 0.1 0
Sleep Apnea 0.2 0.1 1
Small Intestinal Bacterial Overgrowth (SIBO) 0.1 0.1 0
Stress / posttraumatic stress disorder 0.2 0.2 0
Systemic Lupus Erythematosus 0.3 0.1 2
Tic Disorder 0.2 0.1 1
Tourette syndrome 0 0
Type 1 Diabetes 0.6 0.2 2
Type 2 Diabetes 0.8 0.7 0.14
Ulcerative colitis 0.3 0.5 -0.67
Unhealthy Ageing 0.4 0.1 3

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