🍽️ clidinium bromide,(prescription) [Can cause cognitive issues]

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  1. Gastrointestinal Conditions: Clidinium bromide is commonly prescribed for the management of gastrointestinal disorders such as peptic ulcers, gastritis, irritable bowel syndrome (IBS), and functional dyspepsia. It works by reducing gastrointestinal spasms and motility, thereby relieving symptoms such as abdominal pain, cramping, bloating, and discomfort.

  2. Peptic Ulcers: Clidinium bromide may be used as part of combination therapy for the treatment of peptic ulcers, which are sores that develop on the lining of the stomach, small intestine, or esophagus due to excessive stomach acid production or infection with Helicobacter pylori bacteria. By reducing stomach acid secretion and inhibiting gastrointestinal motility, clidinium bromide helps to promote ulcer healing and alleviate symptoms associated with peptic ulcers, such as abdominal pain and indigestion.

  3. Irritable Bowel Syndrome (IBS): Clidinium bromide is also used in the management of irritable bowel syndrome (IBS), a chronic gastrointestinal disorder characterized by abdominal pain, bloating, diarrhea, and/or constipation. It helps to reduce gastrointestinal spasms and normalize bowel function, thereby relieving symptoms and improving quality of life in individuals with IBS.

  4. Functional Dyspepsia: Clidinium bromide may be prescribed for the treatment of functional dyspepsia, a condition characterized by recurrent or persistent upper abdominal pain or discomfort without evidence of organic disease. It helps to alleviate symptoms such as early satiety, bloating, nausea, and belching by reducing gastrointestinal motility and promoting gastric emptying.

  5. Safety Concerns: Clidinium bromide may cause certain side effects, including dry mouth, blurred vision, constipation, urinary retention, and cognitive impairment (such as confusion, dizziness, or drowsiness). These side effects are more common in elderly patients and may be exacerbated by factors such as dehydration, concurrent use of other medications with anticholinergic effects, and underlying medical conditions affecting cognition or urinary function.

  6. Contraindications: Clidinium bromide is contraindicated in individuals with a history of hypersensitivity to anticholinergic medications or any of its components, as well as in patients with narrow-angle glaucoma, obstructive urinary disorders, severe ulcerative colitis, myasthenia gravis, or toxic megacolon. It should be used with caution in elderly patients and those with conditions predisposing to urinary retention or cognitive impairment.

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Data Contradictions β€” Limits of Certainity

Impacted of clidinium bromide,(prescription) [Can cause cognitive issues] On Probiotics

Rank Probiotic Impact
species Bifidobacterium longum Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by clidinium bromide,(prescription) [Can cause cognitive issues]

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Thomasclavelia genus Decreases 👪 Source Study
Mediterraneibacter genus Decreases 👪 Source Study
Roseburia genus Decreases 👪 Source Study
Coprococcus genus Decreases 👪 Source Study
Blautia genus Decreases 👪 Source Study
Bifidobacterium genus Decreases 👪 Source Study
Lacrimispora genus Decreases 👪 Source Study
Odoribacter genus Decreases 👪 Source Study
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
unclassified Negativicoccus no rank Decreases ⚗️ Source Study
Eggerthellales order Decreases ⚗️ Source Study
Thomasclavelia ramosa species Decreases 📓 Source Study
[Ruminococcus] torques species Decreases 📓 Source Study
Roseburia hominis species Decreases 📓 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Coprococcus comes species Decreases 📓 Source Study
Blautia obeum species Decreases 📓 Source Study
Negativicoccus sp. S5-A15 species Decreases ⚗️ Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Bifidobacterium longum species Decreases 📓 Source Study
Lacrimispora saccharolytica species Decreases 📓 Source Study
Odoribacter splanchnicus species Decreases 📓 Source Study
Coriobacterineae suborder Decreases ⚗️ Source Study
Bifidobacterium longum subsp. infantis subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. longum subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. suillum subspecies Decreases 👶 Source Study
Chlamydiae/Verrucomicrobia group superphylum Decreases ⚗️ Source Study

Impact of clidinium bromide,(prescription) [Can cause cognitive issues] on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Acne 0.1 -0.1
ADHD 0.3 0.1 2
Age-Related Macular Degeneration and Glaucoma 0.1 0.1
Allergic Rhinitis (Hay Fever) 0.2 -0.2
Allergies 0.3 0.3
Allergy to milk products 0.1 -0.1
Alopecia (Hair Loss) 0.1 0.1
Alzheimer's disease 0.1 0.9 -8
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.2 0.2
Ankylosing spondylitis 0.1 0.1
Anorexia Nervosa 0.2 -0.2
Asthma 0.1 0.1 0
Atherosclerosis 0.1 0.1 0
Atrial fibrillation 0.2 0.1 1
Autism 0.6 0.5 0.2
Bipolar Disorder 0.2 -0.2
Brain Trauma 0.1 0.1 0
Carcinoma 0.2 0.2 0
Celiac Disease 0 0.3 0
Cerebral Palsy 0.1 0.2 -1
Chronic Fatigue Syndrome 0.2 0.5 -1.5
Chronic Kidney Disease 0.3 0.2 0.5
Chronic Lyme 0.1 -0.1
Chronic Obstructive Pulmonary Disease (COPD) 0.2 -0.2
Coagulation / Micro clot triggering bacteria 0.2 -0.2
Colorectal Cancer 0.2 0.1 1
Constipation 0.2 -0.2
Coronary artery disease 0.2 -0.2
COVID-19 0.8 0.9 -0.13
Crohn's Disease 0.4 0.4 0
cystic fibrosis 0.2 -0.2
deep vein thrombosis 0.1 -0.1
Depression 0.7 0.6 0.17
Dermatomyositis 0.1 -0.1
Eczema 0.1 -0.1
Endometriosis 0.2 0 0
Epilepsy 0.1 0.1 0
Fibromyalgia 0.5 0.2 1.5
Functional constipation / chronic idiopathic constipation 0.2 0.6 -2
gallstone disease (gsd) 0.1 0.2 -1
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.2 -0.2
Generalized anxiety disorder 0.1 0.3 -2
Gout 0.1 -0.1
Graves' disease 0.1 0.2 -1
Hashimoto's thyroiditis 0.6 0.1 5
Histamine Issues,Mast Cell Issue, DAO Insufficiency 0.2 0.2 0
hypercholesterolemia (High Cholesterol) 0 0
hyperglycemia 0.1 -0.1
Hyperlipidemia (High Blood Fats) 0.1 0.1
hypersomnia 0.1 -0.1
hypertension (High Blood Pressure 0.1 0.6 -5
Hypothyroidism 0.2 -0.2
IgA nephropathy (IgAN) 0.1 -0.1
Inflammatory Bowel Disease 0.4 0.5 -0.25
Insomnia 0.1 0.1 0
Intelligence 0.1 0.1
Intracranial aneurysms 0.1 0.1
Irritable Bowel Syndrome 0.2 0.2 0
Liver Cirrhosis 0.4 0.3 0.33
Long COVID 0.7 0.6 0.17
Low bone mineral density 0.2 -0.2
Lung Cancer 0.1 -0.1
ME/CFS with IBS 0.4 -0.4
ME/CFS without IBS 0.1 0.1 0
Menopause 0.1 0.1
Metabolic Syndrome 0.4 0.7 -0.75
Mood Disorders 0.8 0.6 0.33
multiple chemical sensitivity [MCS] 0.1 -0.1
Multiple Sclerosis 0.3 0.1 2
Multiple system atrophy (MSA) 0.2 0.1 1
Neuropathy (all types) 0.1 0.1
neuropsychiatric disorders (PANDAS, PANS) 0 0
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.1 0.5 -4
NonCeliac Gluten Sensitivity 0.1 -0.1
Obesity 0.9 0.2 3.5
obsessive-compulsive disorder 0.2 0.6 -2
Osteoarthritis 0.3 0.3
Osteoporosis 0.1 -0.1
pancreatic cancer 0 0
Parkinson's Disease 0.1 0.3 -2
Polycystic ovary syndrome 0.1 0.2 -1
Postural orthostatic tachycardia syndrome 0.1 -0.1
Premenstrual dysphoric disorder 0.1 0.1
Psoriasis 0.1 0.2 -1
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 0.3 0.3 0
Rosacea 0.4 0.1 3
Schizophrenia 0.3 0.3 0
scoliosis 0.1 0.1
Sjögren syndrome 0.1 0.1 0
Sleep Apnea 0.2 0.3 -0.5
Small Intestinal Bacterial Overgrowth (SIBO) 0.1 -0.1
Stress / posttraumatic stress disorder 0.2 0.3 -0.5
Systemic Lupus Erythematosus 0.2 0.3 -0.5
Tic Disorder 0 0.1 0
Type 1 Diabetes 0.2 0.1 1
Type 2 Diabetes 0.4 0.4 0
Ulcerative colitis 0.1 0.3 -2
Unhealthy Ageing 0.4 0.3 0.33

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