🍽️ diazoxide,(prescription)

AI Engines For more Details: PerplexityKagi LabsYou

  1. Hyperinsulinism: Diazoxide is commonly used in the management of hyperinsulinism, a condition characterized by excessive secretion of insulin by the pancreas, leading to low blood sugar levels (hypoglycemia). Diazoxide works by inhibiting the release of insulin from pancreatic beta cells, thereby helping to normalize blood sugar levels in individuals with hyperinsulinism.

  2. Congenital Hyperinsulinism (CHI): Diazoxide is particularly effective in the treatment of congenital hyperinsulinism, a rare genetic disorder characterized by abnormal regulation of insulin secretion from the pancreas. In individuals with CHI, diazoxide helps prevent recurrent episodes of hypoglycemia by reducing insulin secretion and promoting glycemic stability.

  3. Insulinoma: Diazoxide may also be used in the management of insulinomas, rare tumors of the pancreas that produce excessive amounts of insulin, leading to hypoglycemia. By inhibiting insulin secretion, diazoxide can help control hypoglycemic symptoms and stabilize blood sugar levels in individuals with insulinomas.

  4. Mechanism of Action: Diazoxide exerts its therapeutic effects by binding to and activating ATP-sensitive potassium (KATP) channels in pancreatic beta cells, which leads to membrane hyperpolarization and inhibition of insulin release. This mechanism helps counteract the excessive insulin secretion characteristic of hyperinsulinism and insulinomas, thereby preventing hypoglycemia.

  5. Oral Administration: Diazoxide is typically administered orally in tablet or suspension form, usually once or twice daily, as directed by a healthcare provider. The dosage may vary depending on the individual's age, weight, medical history, and response to treatment. It's important to follow the prescribed dosage and administration instructions carefully to achieve optimal therapeutic outcomes.

  6. Monitoring: Regular monitoring of blood glucose levels and clinical symptoms is essential during diazoxide therapy to assess treatment response, detect hypoglycemic episodes, and adjust dosage as needed. Close medical supervision is particularly important in individuals with CHI or insulinomas, who may require lifelong treatment with diazoxide to maintain glycemic control.

  7. Side Effects: Common side effects of diazoxide may include fluid retention (edema), sodium and water retention, hypertrichosis (excessive hair growth), gastrointestinal upset (nausea, vomiting, diarrhea), and headache. Less common but potentially serious side effects may include hypotension (low blood pressure), tachycardia (rapid heart rate), and hyperglycemia (high blood sugar).

  8. Contraindications: Diazoxide is contraindicated in individuals with known hypersensitivity or allergy to the medication or any of its components. It should be used with caution in individuals with pre-existing cardiovascular disease, fluid retention, electrolyte imbalances, or renal impairment.

;

Check for interactions on Supp.AI   |   πŸ“š PubMed Citations

βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of diazoxide,(prescription) On Probiotics

Rank Probiotic Impact
species Escherichia coli Reduces
species Lacticaseibacillus paracasei Reduces

Bacteria Impacted by diazoxide,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

πŸ§™?

Taxonomy Rank Effect Citations Notation
Streptococcus genus Decreases 👪 Source Study
Eggerthella genus Decreases 👪 Source Study
Lacticaseibacillus genus Decreases 👪 Source Study
Ruminococcus genus Decreases 👪 Source Study
Coprococcus genus Decreases 👪 Source Study
Escherichia genus Decreases 👪 Source Study
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
unclassified Negativicoccus no rank Decreases ⚗️ Source Study
Escherichia coli O80:H26 no rank Decreases 👶 Source Study
Eggerthellales order Decreases ⚗️ Source Study
Escherichia coli O145 serogroup Decreases 👶 Source Study
Escherichia coli O157 serogroup Decreases 👶 Source Study
Escherichia coli O26 serogroup Decreases 👶 Source Study
Escherichia coli O43 serogroup Decreases 👶 Source Study
Escherichia coli O1:H42 serotype Decreases 👶 Source Study
Escherichia coli O104:H4 serotype Decreases 👶 Source Study
Escherichia coli O121:H19 serotype Decreases 👶 Source Study
Escherichia coli O127:H6 serotype Decreases 👶 Source Study
Escherichia coli O139:H28 serotype Decreases 👶 Source Study
Escherichia coli O157:H7 serotype Decreases 👶 Source Study bloody diarrhea
Escherichia coli O44:H18 serotype Decreases 👶 Source Study
Escherichia coli O55:H7 serotype Decreases 👶 Source Study
Escherichia coli O6:H16 serotype Decreases 👶 Source Study
Escherichia coli O7:K1 serotype Decreases 👶 Source Study
Streptococcus salivarius species Decreases 📓 Source Study Infectious bacteria
Eggerthella lenta species Decreases 📓 Source Study
Lacticaseibacillus paracasei species Decreases 📓 Source Study
Ruminococcus bromii species Decreases 📓 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Negativicoccus sp. S5-A15 species Decreases ⚗️ Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Coprococcus comes species Decreases 📓 Source Study
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Escherichia coli species Decreases 📓 Source Study Diarrheal disease in children and travelers, Foodborne diarrhea outbreaks, hemorrhagic colitis, hemolytic-uremic syndrome
Parvibacter caecicola species Decreases ⚗️ Source Study
Coriobacterineae suborder Decreases ⚗️ Source Study
Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases 👶 Source Study
Chlamydiae/Verrucomicrobia group superphylum Decreases ⚗️ Source Study

Impact of diazoxide,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
ADHD 0.1 0.2 -1
Allergic Rhinitis (Hay Fever) 0.1 0.1
Allergies 0.3 0.2 0.5
Allergy to milk products 0.2 0.1 1
Alzheimer's disease 0.2 0.2 0
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.1 0.2 -1
Ankylosing spondylitis 0.4 0.1 3
Anorexia Nervosa 0.1 -0.1
Antiphospholipid syndrome (APS) 0.3 0.3
Asthma 0.3 0.3
Atherosclerosis 0.1 0.1
Atrial fibrillation 0.4 0.1 3
Autism 0.7 0.5 0.4
Barrett esophagus cancer 0.2 -0.2
benign prostatic hyperplasia 0.1 0.1
Bipolar Disorder 0.2 0.3 -0.5
Cancer (General) 0.3 -0.3
Carcinoma 0.5 0.1 4
Celiac Disease 0.3 0.1 2
Cerebral Palsy 0.2 0.1 1
Chronic Fatigue Syndrome 1.4 0.4 2.5
Chronic Kidney Disease 0.2 0.1 1
Chronic Obstructive Pulmonary Disease (COPD) 0.7 0.1 6
Chronic Urticaria (Hives) 0.4 0.4
Coagulation / Micro clot triggering bacteria 0.4 0.3 0.33
Colorectal Cancer 0.7 0.7
Constipation 0.1 0.1
Coronary artery disease 0.1 0.1 0
COVID-19 0.9 1.2 -0.33
Crohn's Disease 0.5 0.2 1.5
cystic fibrosis 0.2 0.2
deep vein thrombosis 0.2 0.3 -0.5
Depression 1.3 0.9 0.44
Dermatomyositis 0.2 0.2
Eczema 0.1 0.7 -6
Endometriosis 0.5 0.1 4
Epilepsy 0.3 0.3
Fibromyalgia 0.1 -0.1
Functional constipation / chronic idiopathic constipation 0.3 0.1 2
gallstone disease (gsd) 0.2 0.2
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.2 -0.2
Generalized anxiety disorder 0.2 0.1 1
Glioblastoma 0.2 -0.2
Gout 0.1 -0.1
Halitosis 0.2 -0.2
Hidradenitis Suppurativa 0.2 0.2
Histamine Issues 0.1 0.1
hyperglycemia 0.1 0.1
hypertension (High Blood Pressure 0.4 0.3 0.33
Hypothyroidism 0.2 -0.2
Inflammatory Bowel Disease 1 0.4 1.5
Insomnia 0.2 0.2
Intelligence 0.1 0.1
Intracranial aneurysms 0.1 0.1
Irritable Bowel Syndrome 0.3 0.3
Liver Cirrhosis 0.5 0.4 0.25
Long COVID 0.6 0.4 0.5
Low bone mineral density 0.1 -0.1
Lung Cancer 0.1 0.1 0
Mast Cell Issues / mastitis 0.3 0.2 0.5
ME/CFS with IBS 0.2 0.1 1
ME/CFS without IBS 0.8 0.8
Metabolic Syndrome 0.7 0.4 0.75
Mood Disorders 1.5 1 0.5
multiple chemical sensitivity [MCS] 0.7 0.7
Multiple Sclerosis 1.2 0.3 3
Multiple system atrophy (MSA) 0.1 -0.1
Neuropathy (all types) 0.2 0.1 1
neuropsychiatric disorders (PANDAS, PANS) 0.1 0.1
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.3 0.2 0.5
Obesity 0.5 0.9 -0.8
obsessive-compulsive disorder 0.6 0.1 5
Osteoarthritis 0.3 0.1 2
Osteoporosis 0.3 0.3
pancreatic cancer 0.2 0.2
Parkinson's Disease 0.6 0.5 0.2
Polycystic ovary syndrome 0.2 0.2 0
Postural orthostatic tachycardia syndrome 0.1 -0.1
Psoriasis 0.5 0.1 4
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 0.6 0.1 5
Rosacea 0.1 0.1
Schizophrenia 0.3 0.2 0.5
scoliosis 0.1 0.1 0
Sjögren syndrome 0.3 0.3
Sleep Apnea 0.2 0.2 0
Small Intestinal Bacterial Overgrowth (SIBO) 0.3 0.3
Stress / posttraumatic stress disorder 0.1 0.4 -3
Systemic Lupus Erythematosus 0.5 0.1 4
Tic Disorder 0.1 0.1
Type 1 Diabetes 0.2 0.2 0
Type 2 Diabetes 0.7 0.5 0.4
Ulcerative colitis 0.5 0.1 4
Unhealthy Ageing 0.4 0.1 3

This is an Academic site. It generates theoretical models of what may benefit a specific microbiome results.

Explanations/Info/Descriptions are influenced by Large Language Models and may not be accurate and include some hallucinations. Please report any to us for correction.

Copyright 2016-2024 Lassesen Consulting, LLC [2007], DBA, Microbiome Prescription All rights served.
Permission to data scrap or reverse engineer is explicitly denied to all users. U.S. Code Title 18 PART I CHAPTER 47 Β§β€―1030, CETS No.185, CFAA
Use of data on this site is prohibited except under written license. There is no charge for individual personal use. Use for any commercial applications or research requires a written license.
Caveat emptor: Analysis and suggestions are based on modelling (and thus infererence) based on studies. The data sources are usually given for those that wish to consider alternative inferences. theories and models.
Inventions/Methodologies on this site are Patent Pending.

Microbiome Prescription do not make any representations that data or analyses available on this site is suitable for human diagnostic purposes, for informing treatment decisions, or for any other purposes and accept no responsibility or liability whatsoever for such use.
This site is not Health Insurance Portability and Accountability Act of 1996 (HIPAA) compliant or equivalent EU laws. [34.239.170 ]

Due to AI drones slamming this site, we have added IP blocking on excessive calls. Email us if you get blocked and send this [34.239.170 ]