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Hypertension (High Blood Pressure): Nitrendipine works by blocking calcium channels in the smooth muscle cells of blood vessels, leading to vasodilation (widening of blood vessels). This reduces peripheral resistance and lowers blood pressure. It is often prescribed as a first-line treatment for hypertension.
Angina Pectoris: Nitrendipine may also be used in the management of angina pectoris, a condition characterized by chest pain or discomfort due to reduced blood flow to the heart muscle. By dilating coronary arteries, nitrendipine can increase myocardial oxygen supply and reduce the frequency and severity of angina episodes.
Raynaud's Phenomenon: In some cases, nitrendipine may be prescribed off-label for the management of Raynaud's phenomenon, a condition characterized by episodic vasospasm of the small arteries, typically in the fingers and toes. Vasodilation induced by nitrendipine can help alleviate symptoms by improving blood flow to the affected areas.
Vasospastic Disorders: Nitrendipine may also be used off-label in the treatment of other vasospastic disorders, such as Prinzmetal's angina (variant angina) and peripheral vascular disease, where vasospasm contributes to symptoms.
Prevention of Migraine Headaches: Some studies suggest that calcium channel blockers like nitrendipine may have a role in preventing migraine headaches, particularly those associated with vasospasm. However, more research is needed to establish its efficacy and safety for this indication.
Diastolic Heart Failure: Nitrendipine may be considered in the management of diastolic heart failure, a condition characterized by impaired relaxation of the heart muscle during diastole. By reducing systemic vascular resistance, it can help improve ventricular filling and decrease left ventricular diastolic pressure.
Renal Protection: Some evidence suggests that calcium channel blockers like nitrendipine may have renal protective effects in patients with chronic kidney disease, particularly in those with proteinuria. By lowering blood pressure and reducing intraglomerular pressure, they may slow the progression of kidney damage.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Lacticaseibacillus paracasei | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| ADHD | 2 | 0.1 | 19 |
| Age-Related Macular Degeneration and Glaucoma | 0.2 | 0.4 | -1 |
| Allergic Rhinitis (Hay Fever) | 0.9 | 0.9 | |
| Allergies | 1.6 | 1.8 | -0.13 |
| Allergy to milk products | 0.8 | 0.4 | 1 |
| Alopecia (Hair Loss) | 0.8 | 0.8 | |
| Alzheimer's disease | 1.6 | 2.4 | -0.5 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.8 | 0.4 | 1 |
| Ankylosing spondylitis | 2 | 0.9 | 1.22 |
| Anorexia Nervosa | 0.4 | 1 | -1.5 |
| Antiphospholipid syndrome (APS) | 1.4 | 1.4 | |
| Asthma | 0.6 | -0.6 | |
| Atherosclerosis | 0.4 | 0.6 | -0.5 |
| Atrial fibrillation | 1.5 | 1.8 | -0.2 |
| Autism | 5.1 | 3.8 | 0.34 |
| Barrett esophagus cancer | 0.2 | -0.2 | |
| Bipolar Disorder | 1.3 | 0.7 | 0.86 |
| Brain Trauma | 0.6 | -0.6 | |
| Carcinoma | 1.4 | 1.3 | 0.08 |
| Celiac Disease | 1 | 1.3 | -0.3 |
| Cerebral Palsy | 0.2 | 1 | -4 |
| Chronic Fatigue Syndrome | 2.9 | 2.9 | 0 |
| Chronic Kidney Disease | 1.4 | 0.3 | 3.67 |
| Chronic Lyme | 0.6 | -0.6 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 0.8 | 0.3 | 1.67 |
| Chronic Urticaria (Hives) | 0.2 | 1.7 | -7.5 |
| Coagulation / Micro clot triggering bacteria | 0.6 | 0.8 | -0.33 |
| Colorectal Cancer | 2.8 | 2.8 | |
| Constipation | 0.8 | 0.2 | 3 |
| Coronary artery disease | 0.5 | 0.1 | 4 |
| COVID-19 | 4.9 | 7 | -0.43 |
| Crohn's Disease | 3.3 | 2.3 | 0.43 |
| cystic fibrosis | 0.6 | -0.6 | |
| deep vein thrombosis | 0.8 | -0.8 | |
| Depression | 5.1 | 3.3 | 0.55 |
| Dermatomyositis | 0.2 | 0.2 | |
| Eczema | 0.1 | 1.5 | -14 |
| Endometriosis | 1.1 | 0.4 | 1.75 |
| Epilepsy | 1.3 | 1.8 | -0.38 |
| Fibromyalgia | 2.3 | 2.5 | -0.09 |
| Functional constipation / chronic idiopathic constipation | 2.8 | 2.9 | -0.04 |
| gallstone disease (gsd) | 0.9 | 0.2 | 3.5 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 1.1 | 0.2 | 4.5 |
| Generalized anxiety disorder | 0.1 | 0.5 | -4 |
| Glioblastoma | 0.2 | -0.2 | |
| Gout | 0.1 | -0.1 | |
| Graves' disease | 0.8 | 0.2 | 3 |
| Halitosis | 0.4 | 0.2 | 1 |
| Hashimoto's thyroiditis | 1.1 | 0.4 | 1.75 |
| Hidradenitis Suppurativa | 0.2 | 0.2 | |
| Histamine Issues,Mast Cell Issue, DAO Insufficiency | 0.8 | 0.1 | 7 |
| hyperglycemia | 0.8 | -0.8 | |
| hypertension (High Blood Pressure | 1.4 | 1.6 | -0.14 |
| Hypothyroidism | 0.1 | -0.1 | |
| Hypoxia | 0.8 | 0.8 | |
| IgA nephropathy (IgAN) | 2.8 | -2.8 | |
| Inflammatory Bowel Disease | 2.7 | 4.9 | -0.81 |
| Insomnia | 0.6 | 0.6 | 0 |
| Intelligence | 1 | 1 | 0 |
| Intracranial aneurysms | 1.3 | 1.3 | |
| Irritable Bowel Syndrome | 1.9 | 2.4 | -0.26 |
| Liver Cirrhosis | 1.7 | 1.3 | 0.31 |
| Long COVID | 3.7 | 3.2 | 0.16 |
| Low bone mineral density | 0.3 | -0.3 | |
| Lung Cancer | 0.4 | -0.4 | |
| ME/CFS with IBS | 0.6 | 0.6 | 0 |
| ME/CFS without IBS | 0.4 | 1.2 | -2 |
| Metabolic Syndrome | 2.5 | 3.8 | -0.52 |
| Mood Disorders | 5.6 | 3.3 | 0.7 |
| multiple chemical sensitivity [MCS] | 0.7 | 0.7 | |
| Multiple Sclerosis | 1.7 | 4.2 | -1.47 |
| Multiple system atrophy (MSA) | 0.1 | 0.4 | -3 |
| Neuropathy (all types) | 0.2 | 0.2 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 1.2 | 0.9 | 0.33 |
| Obesity | 2.3 | 2.4 | -0.04 |
| obsessive-compulsive disorder | 4.8 | 2.1 | 1.29 |
| Osteoarthritis | 1.4 | 0.4 | 2.5 |
| Osteoporosis | 0.8 | 0.4 | 1 |
| pancreatic cancer | 0.2 | 0.2 | |
| Parkinson's Disease | 0.7 | 2 | -1.86 |
| Polycystic ovary syndrome | 1.7 | 1.1 | 0.55 |
| Postural orthostatic tachycardia syndrome | 0.1 | -0.1 | |
| Premenstrual dysphoric disorder | 0.4 | -0.4 | |
| primary biliary cholangitis | 0.9 | -0.9 | |
| Psoriasis | 1.3 | 2.9 | -1.23 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 2.8 | 1.4 | 1 |
| Rosacea | 1 | 0.2 | 4 |
| Schizophrenia | 2.3 | 0.7 | 2.29 |
| scoliosis | 0.1 | 0.4 | -3 |
| Sjögren syndrome | 1.6 | 1.8 | -0.13 |
| Sleep Apnea | 0.5 | 0.7 | -0.4 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.2 | 0.2 | |
| Stress / posttraumatic stress disorder | 1.1 | 0.7 | 0.57 |
| Systemic Lupus Erythematosus | 1.9 | 0.6 | 2.17 |
| Tic Disorder | 0.8 | 1 | -0.25 |
| Tourette syndrome | 0.4 | -0.4 | |
| Type 1 Diabetes | 2 | 0.8 | 1.5 |
| Type 2 Diabetes | 2.9 | 4.6 | -0.59 |
| Ulcerative colitis | 0.8 | 3.4 | -3.25 |
| Unhealthy Ageing | 3.7 | 0.3 | 11.33 |
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