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Anesthesia Induction: Propofol is widely used for the induction of anesthesia due to its rapid onset of action. It induces unconsciousness within seconds of administration, allowing for smooth and rapid anesthesia induction.
Maintenance of Anesthesia: Propofol is also used for the maintenance of anesthesia during surgical procedures. It provides a stable and controllable level of anesthesia, allowing for the duration of anesthesia to be adjusted as needed.
Sedative Properties: In addition to its anesthetic properties, propofol exhibits sedative effects, making it useful for sedation in critical care settings, such as in the intensive care unit (ICU) or during certain medical procedures.
Rapid Recovery: One of the advantages of propofol is its rapid metabolism and elimination from the body, leading to quick recovery from anesthesia. This property allows patients to regain consciousness and cognitive function more quickly compared to other anesthetic agents.
Antiemetic Effects: Propofol has been shown to have antiemetic (anti-nausea and anti-vomiting) properties, which can help reduce postoperative nausea and vomiting (PONV) in surgical patients.
Hypotension: A common side effect of propofol administration is transient hypotension (low blood pressure), which may occur due to its vasodilatory effects. Hypotension is usually mild and transient but may require intervention, particularly in hemodynamically unstable patients.
Respiratory Depression: Propofol can cause dose-dependent respiratory depression, leading to a decrease in respiratory rate and depth. This effect is more pronounced when propofol is administered rapidly or in high doses and may necessitate assisted ventilation in some cases.
Pain on Injection: Propofol has been associated with pain upon injection, particularly when administered into small veins or when not adequately diluted or premedicated with a local anesthetic agent.
Propofol Infusion Syndrome (PRIS): In rare cases, prolonged or high-dose infusion of propofol has been associated with a potentially fatal condition known as propofol infusion syndrome (PRIS). PRIS is characterized by metabolic acidosis, rhabdomyolysis, hyperkalemia, renal failure, and cardiac failure.
Allergic Reactions: Although uncommon, allergic reactions to propofol, including rash, itching, and anaphylaxis, have been reported. Patients with a history of allergic reactions to propofol or its constituents should avoid its use.
| Rank | Probiotic | Impact |
|---|
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| ADHD | 0.1 | -0.1 | |
| Allergic Rhinitis (Hay Fever) | 0 | 0 | |
| Allergies | 0.1 | 0.1 | |
| Allergy to milk products | 0 | 0 | |
| Alzheimer's disease | 0 | 0.1 | 0 |
| Ankylosing spondylitis | 0 | 0 | |
| Anorexia Nervosa | 0 | 0 | |
| Asthma | 0.2 | 0 | 0 |
| Atrial fibrillation | 0 | 0 | 0 |
| Autism | 0.3 | 0 | 0 |
| Bipolar Disorder | 0 | 0.1 | 0 |
| Brain Trauma | 0 | 0 | |
| Carcinoma | 0.1 | 0 | 0 |
| Celiac Disease | 0 | 0 | 0 |
| Cerebral Palsy | 0 | 0 | |
| Chronic Fatigue Syndrome | 0.5 | 0 | 0 |
| Chronic Kidney Disease | 0.2 | 0.2 | |
| Chronic Lyme | 0 | 0 | |
| Colorectal Cancer | 0 | 0 | |
| Constipation | 0 | 0 | |
| COVID-19 | 0.4 | 0.2 | 1 |
| Crohn's Disease | 0.1 | 0 | 0 |
| cystic fibrosis | 0 | 0 | |
| Depression | 0.7 | 0 | 0 |
| Endometriosis | 0 | 0 | |
| Epilepsy | 0 | 0 | 0 |
| Fibromyalgia | 0 | 0 | 0 |
| Functional constipation / chronic idiopathic constipation | 0 | 0.1 | 0 |
| Generalized anxiety disorder | 0 | 0 | |
| Graves' disease | 0 | 0 | |
| Halitosis | 0 | 0 | |
| Hashimoto's thyroiditis | 0.1 | 0 | 0 |
| Histamine Issues,Mast Cell Issue, DAO Insufficiency | 0 | 0 | 0 |
| hyperglycemia | 0 | 0 | |
| hypertension (High Blood Pressure | 0 | 0 | 0 |
| Hypothyroidism | 0.1 | -0.1 | |
| Hypoxia | 0 | 0 | |
| Inflammatory Bowel Disease | 0.2 | 0 | 0 |
| Insomnia | 0 | 0 | 0 |
| Intracranial aneurysms | 0 | 0 | |
| Irritable Bowel Syndrome | 0 | 0 | 0 |
| Liver Cirrhosis | 0 | 0 | 0 |
| Long COVID | 0.2 | 0 | 0 |
| ME/CFS with IBS | 0 | 0 | 0 |
| ME/CFS without IBS | 0.5 | 0 | 0 |
| Metabolic Syndrome | 0.1 | 0 | 0 |
| Mood Disorders | 0.7 | 0.1 | 6 |
| Multiple Sclerosis | 0.4 | 0 | 0 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0 | 0 | |
| Obesity | 0.1 | 0 | 0 |
| obsessive-compulsive disorder | 0 | 0.1 | 0 |
| Osteoarthritis | 0 | 0 | |
| Osteoporosis | 0.1 | 0 | 0 |
| Parkinson's Disease | 0.1 | 0.1 | |
| Polycystic ovary syndrome | 0 | 0 | |
| Psoriasis | 0 | 0 | |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 0.1 | 0 | 0 |
| Rosacea | 0 | 0 | |
| Schizophrenia | 0.1 | 0.1 | |
| Sjögren syndrome | 0 | 0 | |
| Sleep Apnea | 0.1 | -0.1 | |
| Stress / posttraumatic stress disorder | 0 | 0.2 | 0 |
| Systemic Lupus Erythematosus | 0.1 | 0.1 | |
| Tourette syndrome | 0 | 0 | |
| Type 1 Diabetes | 0 | 0 | |
| Type 2 Diabetes | 0.1 | 0 | 0 |
| Ulcerative colitis | 0 | 0 | 0 |
| Unhealthy Ageing | 0.2 | 0.2 |
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