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Organophosphate Poisoning: Pralidoxime chloride is used as an antidote for poisoning by organophosphorus compounds, which inhibit the enzyme acetylcholinesterase. This inhibition leads to an accumulation of acetylcholine at nerve endings, causing overstimulation of the nervous system and resulting in symptoms such as excessive salivation, lacrimation (tearing), sweating, vomiting, diarrhea, muscle weakness, respiratory distress, seizures, and ultimately, respiratory failure and death. Pralidoxime chloride works by reactivating acetylcholinesterase, thereby restoring its normal function and reducing the toxic effects of organophosphates.
Nerve Agent Poisoning: Organophosphorus compounds are also used as chemical warfare agents, commonly known as nerve agents. Pralidoxime chloride is part of the standard treatment regimen for nerve agent poisoning, along with other medications such as atropine. Nerve agents act similarly to organophosphate pesticides but are much more potent and rapidly acting. Pralidoxime chloride plays a crucial role in reversing the toxic effects of nerve agents and improving the chances of survival in affected individuals.
Mechanism of Action: Pralidoxime chloride works by binding to and reactivating acetylcholinesterase, which has been inhibited by organophosphorus compounds. This allows acetylcholinesterase to break down excess acetylcholine, restoring normal neurotransmission and alleviating the symptoms of poisoning. However, pralidoxime chloride is most effective when administered promptly after exposure to organophosphates, as delayed treatment may result in irreversible damage or death.
Administration: Pralidoxime chloride is typically administered intravenously or intramuscularly, with the dosage depending on the severity of poisoning and the specific agent involved. It is often given in combination with atropine, which helps counteract the effects of excess acetylcholine in the body.
Side Effects: Common side effects of pralidoxime chloride include headache, dizziness, blurred vision, dry mouth, flushing, increased sweating, and injection site reactions. In some cases, high doses of pralidoxime chloride may cause muscle weakness or respiratory depression. Patients should be monitored closely for adverse effects, especially during treatment for severe poisoning.
Contraindications: Pralidoxime chloride is contraindicated in individuals with a known hypersensitivity to the medication or its components. It should be used with caution in patients with certain medical conditions such as renal impairment or myasthenia gravis, as dose adjustments may be necessary to prevent complications.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Akkermansia muciniphila | Reduces |
| species | Bacteroides uniformis | Reduces |
| species | Escherichia coli | Reduces |
| species | Lacticaseibacillus paracasei | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| ADHD | 0.6 | 0.6 | |
| Age-Related Macular Degeneration and Glaucoma | 0.2 | 0 | 0 |
| Allergic Rhinitis (Hay Fever) | 0.9 | 0.9 | |
| Allergies | 0.3 | 0.2 | 0.5 |
| Allergy to milk products | 0.2 | 0.1 | 1 |
| Alzheimer's disease | 0.6 | 0.5 | 0.2 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.6 | 0.3 | 1 |
| Ankylosing spondylitis | 0.1 | 0.8 | -7 |
| Anorexia Nervosa | 0 | 0.3 | 0 |
| Antiphospholipid syndrome (APS) | 0.4 | 0.4 | |
| Asthma | 0.7 | -0.7 | |
| Atherosclerosis | 0 | 0.6 | 0 |
| Atrial fibrillation | 0.2 | 0.2 | 0 |
| Autism | 1.4 | 1 | 0.4 |
| Barrett esophagus cancer | 0 | 0 | |
| benign prostatic hyperplasia | 0 | 0 | |
| Biofilm | 0.7 | 0.7 | |
| Bipolar Disorder | 0.2 | 0.2 | 0 |
| Brain Trauma | 0.3 | -0.3 | |
| Cancer (General) | 0.2 | -0.2 | |
| Carcinoma | 0.2 | 0.2 | 0 |
| Celiac Disease | 0.2 | 0.3 | -0.5 |
| Cerebral Palsy | 0.1 | 0.3 | -2 |
| Chronic Fatigue Syndrome | 1.3 | 0.3 | 3.33 |
| Chronic Kidney Disease | 0.9 | 0.2 | 3.5 |
| Chronic Lyme | 0.3 | -0.3 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 0 | 0.2 | 0 |
| Chronic Urticaria (Hives) | 0.1 | 0.4 | -3 |
| Coagulation / Micro clot triggering bacteria | 0.1 | 0.2 | -1 |
| Colorectal Cancer | 0.7 | 0.7 | |
| Constipation | 0.2 | 0.2 | 0 |
| Coronary artery disease | 0.6 | 0.6 | |
| COVID-19 | 1 | 1.3 | -0.3 |
| Crohn's Disease | 1.8 | 0.7 | 1.57 |
| cystic fibrosis | 0.1 | 0.3 | -2 |
| deep vein thrombosis | 0.1 | 0.2 | -1 |
| Depression | 1.3 | 1 | 0.3 |
| Eczema | 0.7 | 0.2 | 2.5 |
| Endometriosis | 0.3 | 0.3 | |
| Eosinophilic Esophagitis | 0 | 0 | |
| Epilepsy | 0.5 | 0.6 | -0.2 |
| Fibromyalgia | 0.3 | 0.5 | -0.67 |
| Functional constipation / chronic idiopathic constipation | 0.8 | 0.5 | 0.6 |
| gallstone disease (gsd) | 0.1 | 0.2 | -1 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.2 | 0.2 | |
| Generalized anxiety disorder | 0.7 | 0.2 | 2.5 |
| Graves' disease | 0.2 | 0.2 | 0 |
| Halitosis | 0.2 | 0.2 | |
| Hashimoto's thyroiditis | 0.4 | 0.2 | 1 |
| Hidradenitis Suppurativa | 0 | 0 | |
| High Histamine/low DAO | 0.2 | 0.2 | |
| hypercholesterolemia (High Cholesterol) | 0.2 | -0.2 | |
| hyperglycemia | 0.1 | 0.5 | -4 |
| Hyperlipidemia (High Blood Fats) | 0.1 | 0.1 | |
| hypertension (High Blood Pressure | 0.4 | 0.6 | -0.5 |
| Hypoxia | 0.3 | 0.3 | |
| IgA nephropathy (IgAN) | 1 | -1 | |
| Inflammatory Bowel Disease | 1.1 | 1.2 | -0.09 |
| Insomnia | 0.2 | 0.3 | -0.5 |
| Intelligence | 0.3 | 0.3 | |
| Intracranial aneurysms | 0.2 | 0.2 | |
| Irritable Bowel Syndrome | 0.7 | 0.9 | -0.29 |
| Liver Cirrhosis | 0.5 | 0.4 | 0.25 |
| Long COVID | 1 | 0.4 | 1.5 |
| Low bone mineral density | 0.2 | -0.2 | |
| Lung Cancer | 0 | 0.2 | 0 |
| Mast Cell Issues / mastitis | 0 | 0 | |
| ME/CFS with IBS | 0.2 | -0.2 | |
| ME/CFS without IBS | 0.6 | 0.2 | 2 |
| Metabolic Syndrome | 1.4 | 1.3 | 0.08 |
| Mood Disorders | 1.5 | 1 | 0.5 |
| multiple chemical sensitivity [MCS] | 0.1 | 0.1 | |
| Multiple Sclerosis | 0.4 | 0.6 | -0.5 |
| Multiple system atrophy (MSA) | 0.3 | 0.3 | |
| neuropathic pain | 0.3 | -0.3 | |
| Neuropathy (all types) | 0.1 | 0 | 0 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.1 | 0.1 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0 | 0.4 | 0 |
| NonCeliac Gluten Sensitivity | 0.2 | 0.2 | 0 |
| Obesity | 1.2 | 0.7 | 0.71 |
| obsessive-compulsive disorder | 0.8 | 1 | -0.25 |
| Osteoarthritis | 0.8 | 0.8 | |
| Osteoporosis | 0.2 | 0.4 | -1 |
| Parkinson's Disease | 0.9 | 0.9 | 0 |
| Polycystic ovary syndrome | 0.2 | 0.3 | -0.5 |
| Premenstrual dysphoric disorder | 0 | 0 | |
| primary biliary cholangitis | 0.3 | -0.3 | |
| Psoriasis | 0.4 | 0.6 | -0.5 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 1.2 | 0.5 | 1.4 |
| Rosacea | 0.2 | -0.2 | |
| Schizophrenia | 0.8 | 0.2 | 3 |
| Sjögren syndrome | 0.1 | 0.5 | -4 |
| Sleep Apnea | 0 | 0.3 | 0 |
| Slow gastric motility / Gastroparesis | 0.2 | 0.2 | |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.1 | 0.1 | |
| Stress / posttraumatic stress disorder | 0.6 | 0.6 | 0 |
| Systemic Lupus Erythematosus | 1.1 | 0.2 | 4.5 |
| Tic Disorder | 0 | 0 | |
| Tourette syndrome | 0.1 | 0.2 | -1 |
| Type 1 Diabetes | 0.4 | 0.2 | 1 |
| Type 2 Diabetes | 1.4 | 1.3 | 0.08 |
| Ulcerative colitis | 0.3 | 1.1 | -2.67 |
| Unhealthy Ageing | 1.1 | 0.3 | 2.67 |
| Vitiligo | 0.2 | 0.2 | 0 |
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