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Appetite Stimulation: One of the primary uses of megestrol acetate is to stimulate appetite and promote weight gain in patients with conditions such as cancer-related cachexia (severe weight loss and muscle wasting), HIV/AIDS-related wasting syndrome, and anorexia nervosa. It works by increasing appetite and food intake, leading to improved nutritional status and weight gain in affected individuals.
Cancer Treatment: Megestrol acetate may be used as part of cancer treatment regimens, particularly in patients with advanced or metastatic breast cancer, endometrial cancer, and prostate cancer. It may help slow the progression of certain hormone-sensitive tumors by inhibiting the growth-promoting effects of estrogen or androgens on cancer cells.
Hormone Therapy: In some cases, megestrol acetate is prescribed as hormone replacement therapy for women experiencing menopausal symptoms such as hot flashes, vaginal dryness, and mood changes. It may help alleviate these symptoms by providing supplemental progestin activity.
Endometrial Hyperplasia: Megestrol acetate is sometimes used to treat endometrial hyperplasia, a condition characterized by abnormal thickening of the uterine lining. By promoting shedding of the uterine lining (similar to a menstrual period), it can help reduce the risk of endometrial cancer in women with this condition.
Breast Cancer Prevention: In certain high-risk individuals, such as women with a strong family history of breast cancer or a history of atypical hyperplasia of the breast, megestrol acetate may be prescribed as a preventive measure to reduce the risk of developing breast cancer.
Palliative Care: Megestrol acetate is often used in palliative care settings to improve quality of life and alleviate symptoms in patients with advanced or terminal illness. It can help relieve symptoms such as loss of appetite, fatigue, and cachexia, thereby improving overall comfort and well-being.
Hormonal Contraception: In veterinary medicine, megestrol acetate is used as a hormonal contraceptive for dogs and cats. It inhibits estrus (heat) and prevents pregnancy in female animals.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Escherichia coli | Reduces |
| species | Lacticaseibacillus paracasei | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| ADHD | 1 | 1 | |
| Age-Related Macular Degeneration and Glaucoma | 0.1 | 0.5 | -4 |
| Allergic Rhinitis (Hay Fever) | 1.4 | 1.4 | |
| Allergies | 1.4 | 0.6 | 1.33 |
| Allergy to milk products | 1.2 | 0.9 | 0.33 |
| Alopecia (Hair Loss) | 0.9 | 0.9 | |
| Alzheimer's disease | 1.6 | 0.7 | 1.29 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.9 | 1 | -0.11 |
| Ankylosing spondylitis | 3.2 | 0.5 | 5.4 |
| Anorexia Nervosa | 0.5 | 0.3 | 0.67 |
| Antiphospholipid syndrome (APS) | 1.4 | 1.4 | |
| Asthma | 0.3 | -0.3 | |
| Atherosclerosis | 0.3 | -0.3 | |
| Atrial fibrillation | 0.9 | 1.8 | -1 |
| Autism | 2.5 | 2.7 | -0.08 |
| Barrett esophagus cancer | 0.3 | -0.3 | |
| benign prostatic hyperplasia | 0.5 | 0.5 | |
| Biofilm | 1.6 | 1.6 | |
| Bipolar Disorder | 1.1 | 0.1 | 10 |
| Brain Trauma | 0.3 | -0.3 | |
| Cancer (General) | 0.6 | -0.6 | |
| Carcinoma | 1.4 | 0.7 | 1 |
| Celiac Disease | 1.6 | 0.7 | 1.29 |
| Cerebral Palsy | 0.3 | 0.3 | 0 |
| Chronic Fatigue Syndrome | 2.6 | 2.4 | 0.08 |
| Chronic Kidney Disease | 1.4 | 0.1 | 13 |
| Chronic Lyme | 0.3 | -0.3 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 1.4 | 0.1 | 13 |
| Chronic Urticaria (Hives) | 1.7 | 1 | 0.7 |
| Coagulation / Micro clot triggering bacteria | 2.2 | 0.4 | 4.5 |
| Colorectal Cancer | 3.4 | 3.4 | |
| Constipation | 0.8 | 0.1 | 7 |
| Coronary artery disease | 0.3 | 0.3 | |
| COVID-19 | 3.7 | 2.7 | 0.37 |
| Crohn's Disease | 3.3 | 1.2 | 1.75 |
| cystic fibrosis | 1.5 | 0.3 | 4 |
| deep vein thrombosis | 1.5 | 0.4 | 2.75 |
| Depression | 4.4 | 3 | 0.47 |
| Dermatomyositis | 0.3 | 0.3 | |
| Eczema | 0.8 | 1.5 | -0.88 |
| Endometriosis | 2.4 | 2.4 | |
| Epilepsy | 1.4 | 1.6 | -0.14 |
| Fibromyalgia | 1.5 | 1.3 | 0.15 |
| Functional constipation / chronic idiopathic constipation | 2.8 | 1.4 | 1 |
| gallstone disease (gsd) | 0.9 | 0.1 | 8 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.5 | 0.3 | 0.67 |
| Generalized anxiety disorder | 1.8 | 0.2 | 8 |
| Glioblastoma | 0.3 | -0.3 | |
| Graves' disease | 0.7 | 0.1 | 6 |
| Halitosis | 0.2 | 0.3 | -0.5 |
| Hashimoto's thyroiditis | 0.3 | 0.2 | 0.5 |
| Hidradenitis Suppurativa | 0.3 | 0.3 | |
| High Histamine/low DAO | 1.1 | 1.1 | |
| hyperglycemia | 0.5 | 0.7 | -0.4 |
| hypertension (High Blood Pressure | 1.4 | 1 | 0.4 |
| Hypoxia | 0.7 | 0.7 | |
| IgA nephropathy (IgAN) | 1.3 | -1.3 | |
| Inflammatory Bowel Disease | 3.4 | 2.4 | 0.42 |
| Insomnia | 0.5 | 0.3 | 0.67 |
| Intelligence | 0.4 | 0.6 | -0.5 |
| Intracranial aneurysms | 0.7 | 0.7 | |
| Irritable Bowel Syndrome | 1.8 | 1.3 | 0.38 |
| Liver Cirrhosis | 1.5 | 0.6 | 1.5 |
| Long COVID | 1.8 | 0.8 | 1.25 |
| Low bone mineral density | 0.1 | -0.1 | |
| Lung Cancer | 0.5 | 0.5 | |
| Mast Cell Issues / mastitis | 0.8 | 0.8 | |
| ME/CFS with IBS | 0.3 | 0.2 | 0.5 |
| ME/CFS without IBS | 0.7 | 1.1 | -0.57 |
| Metabolic Syndrome | 3.2 | 2 | 0.6 |
| Mood Disorders | 4.4 | 3 | 0.47 |
| multiple chemical sensitivity [MCS] | 1.1 | 1.1 | |
| Multiple Sclerosis | 1.8 | 3 | -0.67 |
| Multiple system atrophy (MSA) | 0.3 | 0.3 | |
| neuropathic pain | 0.2 | -0.2 | |
| Neuropathy (all types) | 0.3 | 0.5 | -0.67 |
| neuropsychiatric disorders (PANDAS, PANS) | 1 | 1 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 1.4 | 0.2 | 6 |
| NonCeliac Gluten Sensitivity | 0.2 | -0.2 | |
| Obesity | 1.8 | 2 | -0.11 |
| obsessive-compulsive disorder | 3.3 | 1.1 | 2 |
| Osteoarthritis | 1.3 | 1.3 | |
| Osteoporosis | 0.7 | 0.2 | 2.5 |
| pancreatic cancer | 0.3 | 0.3 | |
| Parkinson's Disease | 3.8 | 2.1 | 0.81 |
| Polycystic ovary syndrome | 1.2 | 0.1 | 11 |
| Premenstrual dysphoric disorder | 0.5 | -0.5 | |
| primary biliary cholangitis | 0.4 | -0.4 | |
| Psoriasis | 1.7 | 2.3 | -0.35 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 2.4 | 0.7 | 2.43 |
| Rosacea | 0.1 | -0.1 | |
| Schizophrenia | 1.1 | 0.1 | 10 |
| Sjögren syndrome | 1.8 | 1.1 | 0.64 |
| Sleep Apnea | 0.3 | -0.3 | |
| Slow gastric motility / Gastroparesis | 1.2 | 1.2 | |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1.2 | 1.2 | |
| Stress / posttraumatic stress disorder | 1.7 | 0.3 | 4.67 |
| Systemic Lupus Erythematosus | 2.1 | 0.1 | 20 |
| Tic Disorder | 0.1 | 0.6 | -5 |
| Tourette syndrome | 0.2 | -0.2 | |
| Type 1 Diabetes | 1.2 | 0.5 | 1.4 |
| Type 2 Diabetes | 3.3 | 2.9 | 0.14 |
| Ulcerative colitis | 2.2 | 1.9 | 0.16 |
| Unhealthy Ageing | 1.3 | 0.1 | 12 |
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