🍽️ 2-chloropyrazine non-drug

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  1. Anti-inflammatory Effects: Ursolic acid exhibits anti-inflammatory properties and may help reduce inflammation throughout the body. It can inhibit the production of pro-inflammatory cytokines and mediators, such as tumor necrosis factor-alpha (TNF-Ξ±), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2). Ursolic acid may help alleviate inflammation associated with chronic conditions such as arthritis, inflammatory bowel disease (IBD), and cardiovascular disease.

  2. Antioxidant Activity: Ursolic acid possesses antioxidant properties and can scavenge free radicals and reactive oxygen species (ROS) that can damage cells and contribute to oxidative stress. It may help protect cells and tissues from oxidative damage, reduce lipid peroxidation, and enhance the activity of antioxidant enzymes such as superoxide dismutase (SOD) and catalase. Ursolic acid's antioxidant activity may contribute to its potential health benefits against age-related diseases, neurodegenerative disorders, and cancer.

  3. Anticancer Potential: Ursolic acid has been investigated for its potential anticancer properties and ability to inhibit tumor growth and metastasis. It can induce apoptosis (programmed cell death) in cancer cells, inhibit cell proliferation, and suppress angiogenesis (formation of new blood vessels) and tumor invasion. Ursolic acid may have chemopreventive effects against various types of cancer, including breast, prostate, colon, lung, and skin cancer. It may also enhance the efficacy of conventional cancer treatments such as chemotherapy and radiation therapy.

  4. Antidiabetic Effects: Ursolic acid may help regulate blood glucose levels and improve insulin sensitivity, making it potentially beneficial for individuals with diabetes or insulin resistance. It can inhibit gluconeogenesis (glucose production) in the liver, enhance glucose uptake by cells, and modulate insulin signaling pathways. Ursolic acid may help reduce fasting blood sugar levels, improve glycemic control, and prevent complications associated with diabetes, such as diabetic nephropathy and neuropathy.

  5. Muscle Growth and Fat Loss: Ursolic acid has been studied for its potential effects on muscle growth, strength, and fat loss. It can stimulate muscle protein synthesis, increase muscle mass, and improve exercise performance. Ursolic acid may also promote brown adipose tissue (BAT) activation and thermogenesis, leading to increased energy expenditure and fat burning. It may help prevent obesity, metabolic syndrome, and muscle wasting conditions such as sarcopenia.

  6. Cardioprotective Effects: Ursolic acid may have cardioprotective effects and help prevent cardiovascular diseases such as atherosclerosis, hypertension, and heart failure. It can improve lipid metabolism, reduce cholesterol levels, and inhibit the formation of atherosclerotic plaques in blood vessels. Ursolic acid may also help protect against myocardial ischemia-reperfusion injury, reduce oxidative stress in the heart, and improve cardiac function.

  7. Skin Health: Ursolic acid has been investigated for its potential dermatological benefits and ability to promote skin health and wound healing. It can stimulate collagen production, enhance skin elasticity, and inhibit matrix metalloproteinases (MMPs) that degrade collagen and elastin fibers in the skin. Ursolic acid may help prevent skin aging, reduce wrinkles, and promote wound closure and tissue regeneration. It may be used in topical formulations for the treatment of skin conditions such as dermatitis, eczema, and psoriasis.


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Data Contradictions β€” Limits of Certainity

Impacted of 2-chloropyrazine non-drug On Probiotics

Rank Probiotic Impact
species Lacticaseibacillus paracasei Reduces

Bacteria Impacted by 2-chloropyrazine non-drug

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.


Taxonomy Rank Effect Citations Notation
Lacticaseibacillus genus Decreases 👪 Source Study
Streptococcus genus Decreases 👪 Source Study
Bilophila genus Decreases 👪 Source Study High Level Cause Brain Fog(Cognitive impairment)
Roseburia genus Decreases 👪 Source Study
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
unclassified Negativicoccus no rank Decreases ⚗️ Source Study
Eggerthellales order Decreases ⚗️ Source Study
Lacticaseibacillus paracasei species Decreases 📓 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Negativicoccus sp. S5-A15 species Decreases ⚗️ Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Streptococcus parasanguinis species Decreases 📓 Source Study
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Bilophila wadsworthia species Decreases 📓 Source Study
Roseburia hominis species Decreases 📓 Source Study
Coriobacterineae suborder Decreases ⚗️ Source Study
Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases 👶 Source Study
Chlamydiae/Verrucomicrobia group superphylum Decreases ⚗️ Source Study

Impact of 2-chloropyrazine non-drug on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0 0
ADHD 0 0
Age-Related Macular Degeneration and Glaucoma 0 0
Alzheimer's disease 0 0.1 0
Ankylosing spondylitis 0.1 0.1
Anorexia Nervosa 0 0
Antiphospholipid syndrome (APS) 0.1 0 0
Asthma 0 0
Atherosclerosis 0 0
Atrial fibrillation 0.1 0 0
Autism 0.1 0.1 0
Barrett esophagus cancer 0.1 -0.1
Bipolar Disorder 0 0 0
Brain Trauma 0 0
Cancer (General) 0.5 -0.5
Carcinoma 0.1 0.1
Celiac Disease 0.1 0 0
Cerebral Palsy 0.1 0 0
Chronic Fatigue Syndrome 0.4 0.2 1
Chronic Kidney Disease 0 0
Chronic Lyme 0 0
Chronic Obstructive Pulmonary Disease (COPD) 0.2 0 0
Chronic Urticaria (Hives) 0.1 0.1
Coagulation / Micro clot triggering bacteria 0.1 0.1 0
Colorectal Cancer 0 0
Constipation 0 0
COVID-19 0.1 0.1 0
Crohn's Disease 0.1 0 0
cystic fibrosis 0 0
deep vein thrombosis 0.1 -0.1
Depression 1.1 0.6 0.83
Dermatomyositis 0.1 0.1
Eczema 0.1 -0.1
Endometriosis 0.1 0.1
Epilepsy 0.1 0.1
Fibromyalgia 0 0
Functional constipation / chronic idiopathic constipation 0 0
gallstone disease (gsd) 0 0
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.1 -0.1
Glioblastoma 0.1 -0.1
Graves' disease 0 0
Halitosis 0.1 -0.1
Hashimoto's thyroiditis 0 0 0
Hidradenitis Suppurativa 0.1 0.1
Histamine Issues 0 0
hypersomnia 0 0
hypertension (High Blood Pressure 0.1 0.2 -1
Inflammatory Bowel Disease 0.1 0 0
Insomnia 0.1 0 0
Irritable Bowel Syndrome 0 0 0
Liver Cirrhosis 0.1 0.1 0
Long COVID 0.1 0.1 0
Low bone mineral density 0 0
Mast Cell Issues / mastitis 0.1 0.1
ME/CFS with IBS 0.1 0.1
ME/CFS without IBS 0.2 0.2
Metabolic Syndrome 0.1 0.2 -1
Mood Disorders 1.1 0.6 0.83
multiple chemical sensitivity [MCS] 0.1 0.1
Multiple Sclerosis 0.3 0.1 2
Multiple system atrophy (MSA) 0.2 0.2
neuropathic pain 0 0
Neuropathy (all types) 0.1 0.1
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.1 0.1
Obesity 0.2 0.5 -1.5
obsessive-compulsive disorder 0.1 0.1
Osteoarthritis 0.1 0.1
pancreatic cancer 0.1 0.1
Parkinson's Disease 0.1 0.1 0
Polycystic ovary syndrome 0 0
Psoriasis 0.1 0 0
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 0.1 0 0
Rosacea 0 0
Schizophrenia 0 0 0
scoliosis 0 0
Sjögren syndrome 0.1 0.1
Sleep Apnea 0 0
Small Intestinal Bacterial Overgrowth (SIBO) 0.1 0.1
Stress / posttraumatic stress disorder 0 0 0
Systemic Lupus Erythematosus 0.1 0 0
Type 1 Diabetes 0 0.1 0
Type 2 Diabetes 0.1 0.1 0
Ulcerative colitis 0.3 0.1 2
Unhealthy Ageing 0.1 0 0

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