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🍽️ raclopride non-drug

AI Engines For more Details: PerplexityKagi LabsYou

  1. Dopamine Receptor Antagonism: Raclopride selectively blocks dopamine D2 and D3 receptors in the brain. By antagonizing these receptors, raclopride can modulate dopamine signaling and neurotransmission. This property makes it valuable for studying the role of dopamine receptors in normal brain function and in the pathophysiology of various disorders.

  2. Neuroscientific Research: Raclopride is widely used in neuroscience research to investigate the role of dopamine receptors in neurological and psychiatric conditions such as schizophrenia, Parkinson's disease, addiction, and mood disorders. By blocking dopamine D2 receptors, raclopride can induce behavioral effects in experimental models that may mimic certain aspects of these disorders, providing insights into their underlying mechanisms.

  3. Dopamine Imaging Studies: Raclopride is also used as a radiotracer in positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging studies to visualize and quantify dopamine D2/D3 receptor binding in the brain. These imaging techniques allow researchers to assess dopamine receptor density and availability in vivo, providing valuable information about dopamine function in health and disease.

  4. Side Effects: While raclopride itself is not used therapeutically in humans, it has been well-tolerated in research studies when administered at appropriate doses. However, like any pharmacological agent, raclopride may have potential side effects in experimental models, including changes in locomotor activity, body temperature, and sensory perception. These effects may vary depending on factors such as dose, route of administration, and species differences.

  5. Therapeutic Implications: Although raclopride is not used as a therapeutic drug, its pharmacological effects on dopamine receptors have implications for the development of novel treatments for neurological and psychiatric disorders. By understanding the mechanisms of action of raclopride and related compounds, researchers may identify new drug targets and therapeutic strategies for conditions involving dysregulation of dopamine signaling.

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Data Contradictions β€” Limits of Certainity

Impacted of raclopride non-drug On Probiotics

Rank Probiotic Impact
species Bacteroides uniformis Reduces
species Escherichia coli Reduces
species Lacticaseibacillus paracasei Reduces
species Parabacteroides distasonis Reduces

Bacteria Impacted by raclopride non-drug

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Bilophila genus Decreases 👪 Source Study High Level Cause Brain Fog(Cognitive impairment)
Lacrimispora genus Decreases 👪 Source Study
Escherichia genus Decreases 👪 Source Study
Fusobacterium genus Decreases 👪 Source Study Periodontal disease, Lemierre syndrome, skin ulcers
Bacteroides genus Decreases 👪 Source Study
Phocaeicola genus Decreases 👪 Source Study
Parabacteroides genus Decreases 👪 Source Study BMI, fat percent,blood pressure
Streptococcus genus Decreases 👪 Source Study
Mediterraneibacter genus Decreases 👪 Source Study
Segatella genus Decreases 👪 Source Study
Clostridium genus Decreases 👪 Source Study Pathogen
Lacticaseibacillus genus Decreases 👪 Source Study
Escherichia coli O1:K1:H7 no rank Decreases 👶 Source Study
Escherichia coli O139:H1 no rank Decreases 👶 Source Study
Escherichia coli O141:H4 no rank Decreases 👶 Source Study
Escherichia coli O145:H34 no rank Decreases 👶 Source Study
Escherichia coli O15:H12 no rank Decreases 👶 Source Study
Escherichia coli O155:H21 no rank Decreases 👶 Source Study
Escherichia coli O158:H23 no rank Decreases 👶 Source Study
Escherichia coli O16:H48 no rank Decreases 👶 Source Study
Escherichia coli O170:H18 no rank Decreases 👶 Source Study
Escherichia coli O18ac:H14 no rank Decreases 👶 Source Study
Escherichia coli O19:H7 no rank Decreases 👶 Source Study
Escherichia coli O2:K1:H4 no rank Decreases 👶 Source Study
Escherichia coli O2:K1:H5 no rank Decreases 👶 Source Study
Escherichia coli O2:K1:H7 no rank Decreases 👶 Source Study
Escherichia coli O20:H12 no rank Decreases 👶 Source Study
Escherichia coli O25:H16 no rank Decreases 👶 Source Study
Escherichia coli O55:H7 no rank Decreases 👶 Source Study
Escherichia coli O68:H12 no rank Decreases 👶 Source Study
Escherichia coli O7:H15 no rank Decreases 👶 Source Study
Escherichia coli O78:H51 no rank Decreases 👶 Source Study
Escherichia coli O80:H26 no rank Decreases 👶 Source Study
Escherichia coli O84:H7 no rank Decreases 👶 Source Study
Escherichia coli O85:H1 no rank Decreases 👶 Source Study
Clostridium perfringens A no rank Decreases 👶 Source Study
Clostridium perfringens B no rank Decreases 👶 Source Study
Clostridium perfringens D no rank Decreases 👶 Source Study
Clostridium perfringens E no rank Decreases 👶 Source Study
Escherichia coli O121 serogroup Decreases 👶 Source Study
Escherichia coli O145 serogroup Decreases 👶 Source Study
Escherichia coli O155 serogroup Decreases 👶 Source Study
Escherichia coli O157 serogroup Decreases 👶 Source Study
Escherichia coli O177 serogroup Decreases 👶 Source Study
Escherichia coli O26 serogroup Decreases 👶 Source Study
Escherichia coli O3 serogroup Decreases 👶 Source Study
Escherichia coli O43 serogroup Decreases 👶 Source Study
Escherichia coli O78 serogroup Decreases 👶 Source Study
Escherichia coli O86 serogroup Decreases 👶 Source Study
Escherichia coli O91 serogroup Decreases 👶 Source Study
Escherichia coli H20 serotype Decreases 👶 Source Study
Escherichia coli O1:H42 serotype Decreases 👶 Source Study
Escherichia coli O1:HNT serotype Decreases 👶 Source Study
Escherichia coli O10:H32 serotype Decreases 👶 Source Study
Escherichia coli O100:H21 serotype Decreases 👶 Source Study
Escherichia coli O103:H2 serotype Decreases 👶 Source Study
Escherichia coli O104:H4 serotype Decreases 👶 Source Study
Escherichia coli O111:H- serotype Decreases 👶 Source Study
Escherichia coli O111:H8 serotype Decreases 👶 Source Study
Escherichia coli O111:NM serotype Decreases 👶 Source Study
Escherichia coli O112ab:H8 serotype Decreases 👶 Source Study
Escherichia coli O112ac:H19 serotype Decreases 👶 Source Study
Escherichia coli O113:H21 serotype Decreases 👶 Source Study
Escherichia coli O114:H49 serotype Decreases 👶 Source Study
Escherichia coli O121:H19 serotype Decreases 👶 Source Study
Escherichia coli O125ac:K+:H10 serotype Decreases 👶 Source Study
Escherichia coli O126:H45 serotype Decreases 👶 Source Study
Escherichia coli O127:H6 serotype Decreases 👶 Source Study
Escherichia coli O128ac:H12 serotype Decreases 👶 Source Study
Escherichia coli O139:H28 serotype Decreases 👶 Source Study
Escherichia coli O145:H25 serotype Decreases 👶 Source Study
Escherichia coli O145:H28 serotype Decreases 👶 Source Study
Escherichia coli O145:NM serotype Decreases 👶 Source Study
Escherichia coli O15:H18 serotype Decreases 👶 Source Study
Escherichia coli O150:H6 serotype Decreases 👶 Source Study
Escherichia coli O152:H23 serotype Decreases 👶 Source Study
Escherichia coli O157:H- serotype Decreases 👶 Source Study
Escherichia coli O157:H43 serotype Decreases 👶 Source Study
Escherichia coli O157:H7 serotype Decreases 👶 Source Study bloody diarrhea
Escherichia coli O16:H6 serotype Decreases 👶 Source Study
Escherichia coli O167:H26 serotype Decreases 👶 Source Study
Escherichia coli O174:H21 serotype Decreases 👶 Source Study
Escherichia coli O176:H45 serotype Decreases 👶 Source Study
Escherichia coli O2:H6 serotype Decreases 👶 Source Study
Escherichia coli O2:K2:H1 serotype Decreases 👶 Source Study
Escherichia coli O25:H1 serotype Decreases 👶 Source Study
Escherichia coli O25:NM serotype Decreases 👶 Source Study
Escherichia coli O26:H11 serotype Decreases 👶 Source Study
Escherichia coli O44:H18 serotype Decreases 👶 Source Study
Escherichia coli O45:H2 serotype Decreases 👶 Source Study
Escherichia coli O6:H16 serotype Decreases 👶 Source Study
Escherichia coli O6:K2:H1 serotype Decreases 👶 Source Study
Escherichia coli O7:H4 serotype Decreases 👶 Source Study
Escherichia coli O7:K1 serotype Decreases 👶 Source Study
Escherichia coli O78:H4 serotype Decreases 👶 Source Study
Escherichia coli O8:H8 serotype Decreases 👶 Source Study
Escherichia coli O89m:H10 serotype Decreases 👶 Source Study
Escherichia coli O89m:H9 serotype Decreases 👶 Source Study
Escherichia coli O9:H10 serotype Decreases 👶 Source Study
Escherichia coli O99:H6 serotype Decreases 👶 Source Study
Bilophila wadsworthia species Decreases 📓 Source Study
Lacrimispora saccharolytica species Decreases 📓 Source Study
Escherichia coli species Decreases 📓 Source Study Diarrheal disease in children and travelers, Foodborne diarrhea outbreaks, hemorrhagic colitis, hemolytic-uremic syndrome
Bacteroides uniformis species Decreases 📓 Source Study Infectious bacteria
Fusobacterium nucleatum species Decreases 📓 Source Study Infectious bacteria
Streptococcus salivarius species Decreases 📓 Source Study Infectious bacteria
Parabacteroides merdae species Decreases 📓 Source Study Infectious bacteria
Phocaeicola vulgatus species Decreases 📓 Source Study
Bacteroides fragilis species Decreases 📓 Source Study H02076 Bacteroides infection
Parabacteroides distasonis species Decreases 📓 Source Study
Mediterraneibacter gnavus species Decreases 📓 Source Study
Segatella copri species Decreases 📓 Source Study Over 70%ile Indicator of mycotoxin present
Clostridium perfringens species Decreases 📓 Source Study Food poisoning, gas gangrene
Streptococcus parasanguinis species Decreases 📓 Source Study
Lacticaseibacillus paracasei species Decreases 📓 Source Study
Fusobacterium nucleatum subsp. nucleatum subspecies Decreases 👶 Source Study
Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases 👶 Source Study
Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases 👶 Source Study

Impact of raclopride non-drug on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.5 0.5
ADHD 1.3 1.3
Age-Related Macular Degeneration and Glaucoma 0.2 -0.2
Allergic Rhinitis (Hay Fever) 1.2 1.2
Allergies 1.2 0.2 5
Allergy to milk products 1.1 0.6 0.83
Alopecia (Hair Loss) 0.4 0.4
Alzheimer's disease 2.8 1.7 0.65
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.8 0.7 0.14
Ankylosing spondylitis 1.8 0.9 1
Anorexia Nervosa 0.2 0.3 -0.5
Antiphospholipid syndrome (APS) 0.9 0.5 0.8
Asthma 0.1 0.3 -2
Atherosclerosis 0.4 0.1 3
Atrial fibrillation 0.7 1.5 -1.14
Autism 2.5 2.6 -0.04
Barrett esophagus cancer 0.4 0.2 1
benign prostatic hyperplasia 0.4 0.4
Biofilm 1.8 1.8
Bipolar Disorder 1.3 1.3
Brain Trauma 0.3 -0.3
Cancer (General) 0.1 -0.1
Carcinoma 1.5 0.5 2
Celiac Disease 1.6 1 0.6
Cerebral Palsy 0.2 0.3 -0.5
Chronic Fatigue Syndrome 2.7 2.7 0
Chronic Kidney Disease 1.2 1.2
Chronic Lyme 0.3 -0.3
Chronic Obstructive Pulmonary Disease (COPD) 1.2 1.2
Chronic Urticaria (Hives) 1.3 0.6 1.17
Coagulation / Micro clot triggering bacteria 1.5 0.2 6.5
Colorectal Cancer 3.7 3.7
Constipation 1.1 1.1
Coronary artery disease 0.3 0.3
COVID-19 3.4 2.5 0.36
Crohn's Disease 4.7 1.3 2.62
cystic fibrosis 1.1 0.3 2.67
deep vein thrombosis 1.1 0.2 4.5
Depression 3 1.6 0.88
Dermatomyositis 0.2 0.2
Eczema 0.7 1.3 -0.86
Endometriosis 1.8 1.8
Eosinophilic Esophagitis 0.4 0.4
Epilepsy 1.6 0.9 0.78
Fibromyalgia 0.7 1.3 -0.86
Functional constipation / chronic idiopathic constipation 2.5 0.9 1.78
gallstone disease (gsd) 0.6 0.4 0.5
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 1.2 0.2 5
Generalized anxiety disorder 1.8 0.3 5
giant cell arteritis 0.1 -0.1
Glioblastoma 0.2 -0.2
Graves' disease 0.5 0.5
Halitosis 0.6 0.2 2
Hashimoto's thyroiditis 0.3 0.8 -1.67
Hidradenitis Suppurativa 1 1
High Histamine/low DAO 0.9 0.9
hypercholesterolemia (High Cholesterol) 0.1 0.1
hyperglycemia 0.4 0.5 -0.25
hypersomnia 0.5 -0.5
hypertension (High Blood Pressure 1 1.4 -0.4
Hypoxia 0.5 0.5
IgA nephropathy (IgAN) 1.3 -1.3
Inflammatory Bowel Disease 2.9 1.3 1.23
Insomnia 0.5 0.3 0.67
Intelligence 0.8 0.2 3
Intracranial aneurysms 0.5 0.5
Irritable Bowel Syndrome 1.5 1.7 -0.13
Liver Cirrhosis 1.9 1 0.9
Long COVID 2.1 1.3 0.62
Lung Cancer 0.4 0.4
Mast Cell Issues / mastitis 0.5 0.5
ME/CFS with IBS 0.2 0.3 -0.5
ME/CFS without IBS 0.5 0.7 -0.4
Metabolic Syndrome 3.4 3.2 0.06
Mood Disorders 3.6 1.6 1.25
multiple chemical sensitivity [MCS] 0.8 0.8
Multiple Sclerosis 1.9 1.8 0.06
Multiple system atrophy (MSA) 0 0
neuropathic pain 0.3 -0.3
Neuropathy (all types) 0.2 0.4 -1
neuropsychiatric disorders (PANDAS, PANS) 0.7 0.7
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.8 0.3 1.67
NonCeliac Gluten Sensitivity 0.3 -0.3
Obesity 1.9 1.5 0.27
obsessive-compulsive disorder 3.4 0.8 3.25
Osteoarthritis 1.2 1.2
Osteoporosis 0.7 0.3 1.33
pancreatic cancer 0.2 0.2
Parkinson's Disease 3.4 2.3 0.48
Polycystic ovary syndrome 1.4 0.1 13
Postural orthostatic tachycardia syndrome 0.1 0.1
Premenstrual dysphoric disorder 0.2 -0.2
primary biliary cholangitis 0.7 -0.7
Psoriasis 1.4 1 0.4
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 2.7 1.1 1.45
Rosacea 0.1 -0.1
Schizophrenia 1.9 0.1 18
scoliosis 0.5 -0.5
Sjögren syndrome 0.9 1.2 -0.33
Sleep Apnea 0.4 0.3 0.33
Slow gastric motility / Gastroparesis 1 1
Small Intestinal Bacterial Overgrowth (SIBO) 1.3 1.3
Stress / posttraumatic stress disorder 1.6 0.3 4.33
Systemic Lupus Erythematosus 2.6 2.6
Tic Disorder 0.4 0.2 1
Tourette syndrome 0.3 -0.3
Type 1 Diabetes 2 0.7 1.86
Type 2 Diabetes 3.8 3.4 0.12
Ulcerative colitis 1.6 2.4 -0.5
Unhealthy Ageing 3.2 3.2
Vitiligo 0.6 0.3 1

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