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Cardiovascular Health: L-arginine is a precursor to nitric oxide (NO), a molecule that plays a crucial role in regulating blood vessel tone and blood flow. Nitric oxide helps dilate blood vessels, improve endothelial function, and reduce blood pressure. L-arginine supplementation may help increase nitric oxide production, promote vasodilation, and improve circulation, thereby supporting cardiovascular health. It may also help reduce the risk of conditions such as hypertension, atherosclerosis, and coronary artery disease.
Exercise Performance: L-arginine supplementation has been studied for its potential benefits in enhancing exercise performance and physical endurance. Nitric oxide produced from L-arginine may help increase blood flow to exercising muscles, deliver oxygen and nutrients more efficiently, and remove metabolic waste products such as lactic acid. This may result in improved exercise capacity, reduced fatigue, and faster recovery from intense physical activity.
Wound Healing: L-arginine is involved in the synthesis of collagen, a protein that forms the structural framework of skin and other connective tissues. Adequate levels of L-arginine are essential for wound healing and tissue repair. L-arginine supplementation may help promote collagen synthesis, stimulate angiogenesis (formation of new blood vessels), and enhance the overall healing process in wounds, injuries, and surgical incisions.
Immune Function: L-arginine plays a role in regulating immune function and inflammatory responses. It is required for the production of certain immune cells, such as T cells and macrophages, which play a crucial role in defending the body against infections and diseases. L-arginine supplementation may help support immune function and enhance the body's ability to fight off pathogens and foreign invaders.
Reproductive Health: L-arginine is involved in various aspects of reproductive health, including sperm production, sperm motility, and erectile function. It plays a role in the synthesis of nitric oxide, which is essential for penile erection by relaxing smooth muscle cells in the corpus cavernosum of the penis. L-arginine supplementation may help improve erectile function in men with erectile dysfunction (ED) and support overall reproductive health.
Kidney Health: L-arginine has been studied for its potential benefits in protecting kidney function and reducing the risk of kidney disease. It may help improve renal blood flow, reduce inflammation in the kidneys, and prevent oxidative stress-related damage to renal tissues. L-arginine supplementation may be beneficial for individuals with chronic kidney disease (CKD) or other kidney-related conditions.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Lactobacillus acidophilus | Increases |
| species | Lactobacillus crispatus | Increases |
| species | Lactobacillus gasseri | Increases |
| species | Lactobacillus helveticus | Increases |
| species | Lactobacillus jensenii | Increases |
| species | Lactobacillus johnsonii | Increases |
| species | Lactobacillus kefiranofaciens | Increases |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Acne | 0.6 | 0.6 | |
| ADHD | 0.6 | 0.6 | |
| Allergic Rhinitis (Hay Fever) | 0.6 | 0.2 | 2 |
| Allergies | 0.9 | 0.9 | |
| Alzheimer's disease | 0.3 | 0.3 | |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.6 | -0.6 | |
| Ankylosing spondylitis | 0.6 | 0.6 | |
| Asthma | 0.3 | 0.3 | |
| Atherosclerosis | 0.6 | -0.6 | |
| Atrial fibrillation | 0.6 | -0.6 | |
| Autism | 0.6 | 0.9 | -0.5 |
| Brain Trauma | 0.6 | 0.6 | |
| Celiac Disease | 0.6 | -0.6 | |
| Chronic Fatigue Syndrome | 0.6 | 0.6 | |
| Chronic Kidney Disease | 0.6 | 0.6 | |
| Colorectal Cancer | 0.2 | -0.2 | |
| COVID-19 | 0.6 | 0.6 | 0 |
| Crohn's Disease | 0.6 | 0.8 | -0.33 |
| Depression | 1.3 | 1.3 | 0 |
| Eczema | 0.3 | 0.3 | |
| Endometriosis | 0.9 | 0.9 | |
| Epilepsy | 0.6 | 0.6 | |
| Fibromyalgia | 0.6 | 0.6 | |
| Functional constipation / chronic idiopathic constipation | 0.6 | 0.6 | |
| gallstone disease (gsd) | 0.3 | -0.3 | |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.2 | 0.2 | |
| Graves' disease | 0.6 | -0.6 | |
| Hashimoto's thyroiditis | 0.3 | 0.3 | |
| Histamine Issues,Mast Cell Issue, DAO Insufficiency | 0.4 | -0.4 | |
| hyperglycemia | 0.6 | 0.6 | |
| Hyperlipidemia (High Blood Fats) | 0.9 | 0.9 | |
| hypertension (High Blood Pressure | 0.6 | 0.6 | 0 |
| Hypoxia | 0.6 | -0.6 | |
| IgA nephropathy (IgAN) | 0.6 | 0.6 | |
| Inflammatory Bowel Disease | 0.6 | 0.6 | 0 |
| Insomnia | 0.8 | -0.8 | |
| Intracranial aneurysms | 0.6 | 0.6 | |
| Irritable Bowel Syndrome | 0.6 | 0.6 | 0 |
| Liver Cirrhosis | 0.6 | 0.8 | -0.33 |
| Long COVID | 1.6 | 0.9 | 0.78 |
| ME/CFS with IBS | |||
| ME/CFS without IBS | |||
| Metabolic Syndrome | 0.6 | 1 | -0.67 |
| Mood Disorders | 1.3 | 1.5 | -0.15 |
| multiple chemical sensitivity [MCS] | 0.6 | -0.6 | |
| Multiple Sclerosis | 0.8 | 0.6 | 0.33 |
| Multiple system atrophy (MSA) | 0.6 | -0.6 | |
| Neuropathy (all types) | 0.6 | -0.6 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.3 | -0.3 | |
| Obesity | 0.6 | -0.6 | |
| obsessive-compulsive disorder | 0.6 | 0.6 | |
| Osteoporosis | 0.6 | 0.6 | 0 |
| Parkinson's Disease | 0.8 | 0.9 | -0.13 |
| Polycystic ovary syndrome | 0.6 | -0.6 | |
| Psoriasis | 0.6 | -0.6 | |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 0.9 | 1.1 | -0.22 |
| Rosacea | 0.6 | 0.6 | |
| Schizophrenia | 0.8 | -0.8 | |
| Sjögren syndrome | 0.2 | -0.2 | |
| Stress / posttraumatic stress disorder | 0.6 | -0.6 | |
| Systemic Lupus Erythematosus | 0.9 | 0.6 | 0.5 |
| Tourette syndrome | 0.6 | 0.6 | |
| Type 1 Diabetes | 0.6 | 0.6 | |
| Type 2 Diabetes | 0.6 | 1 | -0.67 |
| Ulcerative colitis | 0.9 | -0.9 | |
| Unhealthy Ageing | 0.2 | 0.6 | -2 |
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