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Healthy Skin, Hair, and Nails: Biotin is often associated with promoting healthy skin, hair, and nails. It is a key nutrient involved in the production of keratin, a protein that makes up the structural components of the skin, hair, and nails. Biotin supplements are sometimes used to improve the strength and appearance of hair and nails and to treat conditions such as brittle nails and hair loss.
Energy Metabolism: Biotin plays a vital role in energy metabolism by facilitating the breakdown of carbohydrates, fats, and proteins into usable energy. It acts as a cofactor for several enzymes involved in metabolic processes, including gluconeogenesis, fatty acid synthesis, and amino acid metabolism.
Blood Sugar Regulation: Some research suggests that biotin may help regulate blood sugar levels and improve insulin sensitivity in individuals with diabetes or metabolic syndrome. Biotin supplementation may reduce fasting blood glucose levels and improve glucose tolerance, although more research is needed to confirm these effects.
Pregnancy and Fetal Development: Biotin is important for fetal development during pregnancy. Adequate biotin intake is necessary for proper embryonic growth and development, and biotin deficiency during pregnancy can increase the risk of birth defects. Pregnant women may require higher levels of biotin to support fetal development.
Neurological Function: Biotin is involved in the synthesis of neurotransmitters and may play a role in maintaining healthy nerve function. Some research suggests that biotin supplementation may have benefits for individuals with certain neurological conditions, such as peripheral neuropathy or multiple sclerosis, although further studies are needed to establish a definitive link.
Muscle Function: Biotin is involved in the metabolism of amino acids, which are the building blocks of proteins. Adequate biotin levels are necessary for proper muscle function and repair, and biotin deficiency can lead to muscle weakness and fatigue.
Support for Metabolic Disorders: Biotin supplementation may be beneficial for individuals with certain metabolic disorders, such as biotinidase deficiency or multiple carboxylase deficiency, which impair the body's ability to metabolize biotin properly. Supplementing with biotin can help correct deficiencies and alleviate symptoms associated with these conditions.
Improvement of Skin Conditions: Biotin may have benefits for certain skin conditions, such as dermatitis or eczema. Some studies suggest that biotin supplementation may help reduce inflammation and improve symptoms of skin disorders, although more research is needed to confirm these effects.
| Rank | Probiotic | Impact |
|---|---|---|
| order | Micrococcales | Increases |
| species | Bacillus aeolius | Increases |
| species | Bacillus horti | Increases |
| species | Bacillus infernus | Increases |
| species | Bacillus pumilus | Increases |
| species | Bacillus thermotolerans | Increases |
| species | Bacillus thuringiensis | Increases |
| species | Bifidobacterium adolescentis | Reduces |
| species | Clostridium beijerinckii | Increases |
| species | Clostridium butyricum | Increases |
| species | Escherichia coli | Reduces |
| species group | Bacillus cereus group | Increases |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Acne | 0.6 | 0.1 | 5 |
| ADHD | 1.9 | 1.4 | 0.36 |
| Allergic Rhinitis (Hay Fever) | 2.5 | 0.6 | 3.17 |
| Allergies | 0.8 | 2.4 | -2 |
| Allergy to milk products | 2 | 0.5 | 3 |
| Alopecia (Hair Loss) | 0.1 | 0.2 | -1 |
| Alzheimer's disease | 2.6 | 3.9 | -0.5 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.5 | 1.4 | -1.8 |
| Ankylosing spondylitis | 0.9 | 3 | -2.33 |
| Anorexia Nervosa | 0.2 | 1.3 | -5.5 |
| Antiphospholipid syndrome (APS) | 0.9 | 0.9 | |
| Asthma | 0.9 | 0.8 | 0.13 |
| Atherosclerosis | 1.5 | 0.8 | 0.88 |
| Atrial fibrillation | 2.1 | 1.3 | 0.62 |
| Autism | 4.1 | 5 | -0.22 |
| Barrett esophagus cancer | 0.2 | 0.6 | -2 |
| benign prostatic hyperplasia | 0.2 | 0.2 | |
| Biofilm | 0.7 | 0.7 | |
| Bipolar Disorder | 1.3 | 1.7 | -0.31 |
| Brain Trauma | 0.6 | 0.4 | 0.5 |
| Breast Cancer | 0.3 | 0.3 | |
| Cancer (General) | 1.4 | 0.6 | 1.33 |
| Carcinoma | 1.7 | 1 | 0.7 |
| Celiac Disease | 2.4 | 1.1 | 1.18 |
| Cerebral Palsy | 0.2 | 1.6 | -7 |
| Chronic Fatigue Syndrome | 5.2 | 2.4 | 1.17 |
| Chronic Kidney Disease | 0.6 | 0.2 | 2 |
| Chronic Lyme | 0.2 | -0.2 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 0.3 | 0.2 | 0.5 |
| Chronic Urticaria (Hives) | 0.6 | 1.3 | -1.17 |
| Coagulation / Micro clot triggering bacteria | 1.1 | 1.1 | 0 |
| Colorectal Cancer | 3 | 0.1 | 29 |
| Constipation | 1.5 | 0.1 | 14 |
| Coronary artery disease | 0.4 | 0.5 | -0.25 |
| COVID-19 | 6.4 | 5.5 | 0.16 |
| Crohn's Disease | 4 | 3.3 | 0.21 |
| cystic fibrosis | 1.1 | 0.9 | 0.22 |
| deep vein thrombosis | 1.1 | 0.4 | 1.75 |
| Depression | 5 | 4.1 | 0.22 |
| Dermatomyositis | 0 | 0.1 | 0 |
| Eczema | 0.8 | 0.5 | 0.6 |
| Endometriosis | 1.2 | 1.7 | -0.42 |
| Eosinophilic Esophagitis | 0.1 | 0 | 0 |
| Epilepsy | 2 | 1.8 | 0.11 |
| erectile dysfunction | 0.2 | -0.2 | |
| Fibromyalgia | 0.3 | 1.2 | -3 |
| Functional constipation / chronic idiopathic constipation | 4.1 | 1.2 | 2.42 |
| gallstone disease (gsd) | 1.2 | 0.5 | 1.4 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.6 | 0.7 | -0.17 |
| Generalized anxiety disorder | 1 | 0.6 | 0.67 |
| giant cell arteritis | 0.2 | 0.3 | -0.5 |
| Glioblastoma | 0 | 0 | |
| Gout | 0.2 | -0.2 | |
| Graves' disease | 0.7 | 2.5 | -2.57 |
| Halitosis | 0.4 | 0 | 0 |
| Hashimoto's thyroiditis | 0.4 | 1.4 | -2.5 |
| Hidradenitis Suppurativa | 0.2 | 0 | 0 |
| High Histamine/low DAO | 1.4 | 0.7 | 1 |
| hypercholesterolemia (High Cholesterol) | 1.1 | -1.1 | |
| hyperglycemia | 1.5 | 1 | 0.5 |
| Hyperlipidemia (High Blood Fats) | 0.8 | 1.4 | -0.75 |
| hypersomnia | 1.1 | 0.1 | 10 |
| hypertension (High Blood Pressure | 2.1 | 2.8 | -0.33 |
| Hypothyroidism | 0.6 | 0.4 | 0.5 |
| Hypoxia | 0.2 | 0.6 | -2 |
| IgA nephropathy (IgAN) | 0.2 | 1.2 | -5 |
| Inflammatory Bowel Disease | 2.9 | 3.3 | -0.14 |
| Insomnia | 0.3 | 1.2 | -3 |
| Intelligence | 0.9 | 0.3 | 2 |
| Intracranial aneurysms | 0.9 | 0.9 | |
| Irritable Bowel Syndrome | 3.9 | 3.7 | 0.05 |
| Juvenile idiopathic arthritis | 0.6 | -0.6 | |
| Liver Cirrhosis | 3.3 | 1.9 | 0.74 |
| Long COVID | 3.7 | 7.1 | -0.92 |
| Low bone mineral density | 0.2 | -0.2 | |
| Lung Cancer | 0.5 | 0.5 | 0 |
| Mast Cell Issues / mastitis | 1.3 | 0.7 | 0.86 |
| ME/CFS with IBS | 0.2 | 1.2 | -5 |
| ME/CFS without IBS | 0.1 | 0.9 | -8 |
| Menopause | 1.4 | 1.4 | |
| Metabolic Syndrome | 4.4 | 4.9 | -0.11 |
| Mood Disorders | 6 | 4.9 | 0.22 |
| multiple chemical sensitivity [MCS] | 0.1 | 0.7 | -6 |
| Multiple Sclerosis | 1.1 | 2.8 | -1.55 |
| Multiple system atrophy (MSA) | 0 | 1.2 | 0 |
| myasthenia gravis | 0.3 | 0.3 | |
| neuropathic pain | 1.4 | 0.2 | 6 |
| Neuropathy (all types) | 0.6 | 0.8 | -0.33 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.4 | 0.4 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.6 | 2.5 | -3.17 |
| NonCeliac Gluten Sensitivity | 0.2 | 1.1 | -4.5 |
| Obesity | 4 | 3.9 | 0.03 |
| obsessive-compulsive disorder | 4.3 | 0.7 | 5.14 |
| Osteoarthritis | 0.4 | 0.6 | -0.5 |
| Osteoporosis | 1.4 | 0.5 | 1.8 |
| pancreatic cancer | 0.2 | 0.2 | |
| Parkinson's Disease | 3.7 | 4.2 | -0.14 |
| Polycystic ovary syndrome | 2.2 | 1.5 | 0.47 |
| Postural orthostatic tachycardia syndrome | 0.6 | -0.6 | |
| Premenstrual dysphoric disorder | 0.2 | 0.2 | 0 |
| primary biliary cholangitis | 0.2 | 0.7 | -2.5 |
| Psoriasis | 1 | 2.4 | -1.4 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 3.9 | 3.3 | 0.18 |
| Rosacea | 0.7 | 1 | -0.43 |
| Schizophrenia | 3.3 | 2.4 | 0.38 |
| scoliosis | 0.2 | 0.4 | -1 |
| Sjögren syndrome | 1.5 | 0.7 | 1.14 |
| Sleep Apnea | 2 | 0.5 | 3 |
| Slow gastric motility / Gastroparesis | 2.2 | 0.1 | 21 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1 | 1 | |
| Stress / posttraumatic stress disorder | 2.3 | 2 | 0.15 |
| Systemic Lupus Erythematosus | 2.4 | 0.9 | 1.67 |
| Tic Disorder | 1.1 | 0.2 | 4.5 |
| Tourette syndrome | 0.8 | -0.8 | |
| Type 1 Diabetes | 2.8 | 1.3 | 1.15 |
| Type 2 Diabetes | 4.8 | 4.5 | 0.07 |
| Ulcerative colitis | 3.3 | 4.9 | -0.48 |
| Unhealthy Ageing | 2.8 | 0.3 | 8.33 |
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