🍽️ methotrexate,(prescription)

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  1. Anticancer Effects: Methotrexate is primarily used as a chemotherapy agent to treat various types of cancer, including leukemia, lymphoma, breast cancer, lung cancer, and head and neck cancers. It works by inhibiting the growth of cancer cells and preventing their reproduction.

  2. Immunosuppressive Effects: Methotrexate is also used as an immunosuppressive agent to treat autoimmune diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, systemic lupus erythematosus (SLE), and inflammatory bowel disease (Crohn's disease and ulcerative colitis). It helps control inflammation and suppresses the immune system's abnormal response.

  3. Ectopic Pregnancy: Methotrexate is used to treat ectopic pregnancies, a condition where a fertilized egg implants outside the uterus, usually in the fallopian tube. Methotrexate stops the growth of the embryo, allowing the body to reabsorb it.

  4. Folate Antagonist: Methotrexate works by inhibiting the enzyme dihydrofolate reductase, which is involved in the synthesis of DNA, RNA, and proteins. By blocking folate metabolism, methotrexate interferes with the proliferation of rapidly dividing cells, including cancer cells and activated immune cells.

  5. Side Effects: Methotrexate can cause a range of side effects, including nausea, vomiting, diarrhea, mouth sores, hair loss, fatigue, headache, dizziness, and skin rashes. These side effects can vary in severity and may require dose adjustments or additional medications to manage.

  6. Bone Marrow Suppression: Methotrexate can suppress bone marrow function, leading to a decrease in the production of blood cells (red blood cells, white blood cells, and platelets). This can result in anemia, leukopenia (low white blood cell count), and thrombocytopenia (low platelet count), increasing the risk of infections and bleeding.

  7. Hepatotoxicity: Methotrexate can cause liver toxicity, characterized by elevated liver enzymes (transaminases) and, in rare cases, liver damage or failure. Regular monitoring of liver function tests is necessary during methotrexate therapy.

  8. Pulmonary Toxicity: In some cases, methotrexate can cause lung problems such as pneumonitis or interstitial lung disease, leading to symptoms like cough, shortness of breath, and chest pain.

  9. Renal Toxicity: Methotrexate can affect kidney function, particularly at high doses or in patients with preexisting kidney disease. Renal toxicity may manifest as elevated serum creatinine levels, decreased urine output, or kidney damage.

  10. Teratogenicity: Methotrexate is contraindicated during pregnancy due to its teratogenic effects, which can cause birth defects or fetal death. Women of childbearing age should use effective contraception during methotrexate treatment and for a period afterward.

  11. Potential for Drug Interactions: Methotrexate can interact with other medications, supplements, or herbal products, potentially affecting its efficacy or increasing the risk of side effects. It's essential for healthcare providers to review a patient's medication regimen carefully before initiating methotrexate therapy.

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βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of methotrexate,(prescription) On Probiotics

Rank Probiotic Impact
species Akkermansia muciniphila Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium longum Reduces
species Escherichia coli Reduces
species Lacticaseibacillus paracasei Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by methotrexate,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Akkermansiaceae family Decreases 👪 Source Study
Streptococcus genus Decreases 👪 Source Study
Lacticaseibacillus genus Decreases 👪 Source Study
Veillonella genus Decreases 👪 Source Study
Thomasclavelia genus Decreases 👪 Source Study
Phocaeicola genus Decreases 👪 Source Study
Enterocloster genus Decreases 👪 Source Study
Clostridium genus Decreases 👪 Source Study Pathogen
Agathobacter genus Decreases 👪 Source Study
Dorea genus Decreases 👪 Source Study
Mediterraneibacter genus Decreases 👪 Source Study
Roseburia genus Decreases 👪 Source Study
Odoribacter genus Decreases 👪 Source Study
Akkermansia genus Decreases 📓 Source Study
Blautia genus Decreases 👪 Source Study
Clostridioides genus Decreases 👪 Source Study
Bifidobacterium genus Decreases 👪 Source Study
Bacteroides genus Decreases 👪 Source Study
Lacrimispora genus Decreases 👪 Source Study
Eggerthella genus Decreases 👪 Source Study
Lachnospira genus Decreases 👪 Source Study
Escherichia genus Decreases 👪 Source Study
Parabacteroides genus Decreases 👪 Source Study BMI, fat percent,blood pressure
Collinsella genus Decreases 👪 Source Study proinflammatory
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
environmental samples no rank Decreases 👶 Source Study
unclassified Akkermansia no rank Decreases 👶 Source Study
Escherichia coli O80:H26 no rank Decreases 👶 Source Study
Eggerthellales order Decreases ⚗️ Source Study
Escherichia coli O145 serogroup Decreases 👶 Source Study
Escherichia coli O157 serogroup Decreases 👶 Source Study
Escherichia coli O26 serogroup Decreases 👶 Source Study
Escherichia coli O43 serogroup Decreases 👶 Source Study
Escherichia coli O1:H42 serotype Decreases 👶 Source Study
Escherichia coli O104:H4 serotype Decreases 👶 Source Study
Escherichia coli O121:H19 serotype Decreases 👶 Source Study
Escherichia coli O127:H6 serotype Decreases 👶 Source Study
Escherichia coli O139:H28 serotype Decreases 👶 Source Study
Escherichia coli O157:H7 serotype Decreases 👶 Source Study bloody diarrhea
Escherichia coli O44:H18 serotype Decreases 👶 Source Study
Escherichia coli O55:H7 serotype Decreases 👶 Source Study
Escherichia coli O6:H16 serotype Decreases 👶 Source Study
Escherichia coli O7:K1 serotype Decreases 👶 Source Study
Streptococcus parasanguinis species Decreases 📓 Source Study
Streptococcus salivarius species Decreases 📓 Source Study Infectious bacteria
Lacticaseibacillus paracasei species Decreases 📓 Source Study
Bacteroides uniformis species Decreases 📓 Source Study Infectious bacteria
Veillonella parvula species Decreases 📓 Source Study
Thomasclavelia ramosa species Decreases 📓 Source Study
Phocaeicola vulgatus species Decreases 📓 Source Study
Enterocloster bolteae species Decreases 📓 Source Study
Clostridium perfringens species Decreases 📓 Source Study Food poisoning, gas gangrene
Agathobacter rectalis species Decreases 📓 Source Study
[Ruminococcus] gnavus species Decreases 📓 Source Study
Roseburia hominis species Decreases 📓 Source Study
Dorea formicigenerans species Decreases 📓 Source Study
Bifidobacterium adolescentis species Decreases 📓 Source Study
Odoribacter splanchnicus species Decreases 📓 Source Study
Akkermansia muciniphila species Decreases 📓 Source Study
Blautia obeum species Decreases 📓 Source Study
Bacteroides fragilis species Decreases 📓 Source Study H02076 Bacteroides infection
Clostridioides difficile species Decreases 📓 Source Study Colitis
Bacteroides xylanisolvens species Decreases 📓 Source Study
Bacteroides ovatus species Decreases 📓 Source Study
[Ruminococcus] torques species Decreases 📓 Source Study
Lacrimispora saccharolytica species Decreases 📓 Source Study
Roseburia intestinalis species Decreases 📓 Source Study
Eggerthella lenta species Decreases 📓 Source Study
Bifidobacterium longum species Decreases 📓 Source Study
Bacteroides thetaiotaomicron species Decreases 📓 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Lachnospira eligens species Decreases 📓 Source Study
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
Bacteroides caccae species Decreases 📓 Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Parabacteroides merdae species Decreases 📓 Source Study Infectious bacteria
Akkermansia glycaniphila species Decreases 👶 Source Study
Escherichia coli species Decreases 📓 Source Study Diarrheal disease in children and travelers, Foodborne diarrhea outbreaks, hemorrhagic colitis, hemolytic-uremic syndrome
Collinsella aerofaciens species Decreases 📓 Source Study
Parabacteroides distasonis species Decreases 📓 Source Study
Coriobacterineae suborder Decreases ⚗️ Source Study
Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. infantis subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. longum subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. suillum subspecies Decreases 👶 Source Study
Chlamydiae/Verrucomicrobia group superphylum Decreases ⚗️ Source Study

Impact of methotrexate,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Acne 0.2 -0.2
ADHD 3.9 0.2 18.5
Age-Related Macular Degeneration and Glaucoma 0.8 0 0
Allergic Rhinitis (Hay Fever) 1.8 1.2 0.5
Allergies 3.1 1.8 0.72
Allergy to milk products 0.8 0.3 1.67
Alopecia (Hair Loss) 0.8 0.8
Alzheimer's disease 2.1 5.6 -1.67
Amyotrophic lateral sclerosis (ALS) Motor Neuron 2.7 0.7 2.86
Ankylosing spondylitis 2.2 1.3 0.69
Anorexia Nervosa 0 1.9 0
Antiphospholipid syndrome (APS) 1.2 1.2
Asthma 1.1 1.5 -0.36
Atherosclerosis 0.3 2.2 -6.33
Atrial fibrillation 2.8 0.6 3.67
Autism 9.3 7.8 0.19
Barrett esophagus cancer 0.5 0.5 0
benign prostatic hyperplasia 0 0
Biofilm 2.1 2.1
Bipolar Disorder 0.3 1 -2.33
Brain Trauma 0.3 0.6 -1
Cancer (General) 0.3 3.2 -9.67
Carcinoma 2.3 1.6 0.44
Celiac Disease 2.7 2.7 0
Cerebral Palsy 2 0.9 1.22
Chronic Fatigue Syndrome 6.9 6.2 0.11
Chronic Kidney Disease 1.9 1.4 0.36
Chronic Lyme 0.6 -0.6
Chronic Obstructive Pulmonary Disease (COPD) 3 0.4 6.5
Chronic Urticaria (Hives) 1.6 1.1 0.45
Coagulation / Micro clot triggering bacteria 0.7 1.1 -0.57
Colorectal Cancer 2.9 0.8 2.62
Constipation 1.4 0.6 1.33
Coronary artery disease 1.5 0.8 0.88
COVID-19 9.1 12.7 -0.4
Crohn's Disease 6.1 4 0.52
cystic fibrosis 0.1 0.8 -7
deep vein thrombosis 0.1 0.8 -7
Depression 9.6 6.5 0.48
Dermatomyositis 0.5 0.2 1.5
Eczema 1.5 2.8 -0.87
Endometriosis 1.9 0.9 1.11
Eosinophilic Esophagitis 0.5 -0.5
Epilepsy 2.2 1.8 0.22
Fibromyalgia 2.7 2 0.35
Functional constipation / chronic idiopathic constipation 3.9 2.4 0.63
gallstone disease (gsd) 1.8 0.6 2
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 2.1 1.1 0.91
Generalized anxiety disorder 1.4 1.3 0.08
giant cell arteritis 0.5 -0.5
Glioblastoma 0.5 -0.5
Graves' disease 0.5 1.1 -1.2
Halitosis 0.7 0.5 0.4
Hashimoto's thyroiditis 2.2 0.5 3.4
Hidradenitis Suppurativa 0.5 0.5 0
High Histamine/low DAO 1.9 0.2 8.5
hypercholesterolemia (High Cholesterol) 0.8 0.6 0.33
hyperglycemia 0.2 1.7 -7.5
Hyperlipidemia (High Blood Fats) 0.6 0 0
hypersomnia 0.3 -0.3
hypertension (High Blood Pressure 1.4 4.9 -2.5
Hypothyroidism 0.7 -0.7
Hypoxia 0.6 0.6
IgA nephropathy (IgAN) 3.5 -3.5
Inflammatory Bowel Disease 4.9 5.4 -0.1
Insomnia 1 0.6 0.67
Intelligence 1.5 1.5
Intracranial aneurysms 0.5 0 0
Irritable Bowel Syndrome 2.9 4.5 -0.55
Liver Cirrhosis 3.8 3.1 0.23
Long COVID 7.6 4.5 0.69
Low bone mineral density 0.4 -0.4
Lung Cancer 0.2 1.3 -5.5
Mast Cell Issues / mastitis 0.5 0.2 1.5
ME/CFS with IBS 2 1.9 0.05
ME/CFS without IBS 2.6 1.9 0.37
Menopause 1.4 1.4
Metabolic Syndrome 5.3 8.4 -0.58
Mood Disorders 12.2 6.7 0.82
multiple chemical sensitivity [MCS] 2.3 0.3 6.67
Multiple Sclerosis 5.2 4.4 0.18
Multiple system atrophy (MSA) 2.9 0.5 4.8
neuropathic pain 1.7 -1.7
Neuropathy (all types) 1.1 0 0
neuropsychiatric disorders (PANDAS, PANS) 0.4 0.4
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 1.8 4.3 -1.39
NonCeliac Gluten Sensitivity 0.2 -0.2
Obesity 7.2 4.5 0.6
obsessive-compulsive disorder 5.5 4 0.38
Osteoarthritis 3.3 3.3
Osteoporosis 1.5 1.1 0.36
pancreatic cancer 0.8 0.8
Parkinson's Disease 2.1 3.1 -0.48
Polycystic ovary syndrome 2.1 1.7 0.24
Postural orthostatic tachycardia syndrome 0.5 0.2 1.5
Premenstrual dysphoric disorder 0.6 0 0
primary biliary cholangitis 0.5 1 -1
Psoriasis 3.9 1.2 2.25
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 3.8 3.2 0.19
Rosacea 0.6 0.8 -0.33
Schizophrenia 6.2 1.4 3.43
scoliosis 0.1 -0.1
Sjögren syndrome 2.7 3.4 -0.26
Sleep Apnea 0.5 1 -1
Slow gastric motility / Gastroparesis 0.8 0.2 3
Small Intestinal Bacterial Overgrowth (SIBO) 0.6 0.3 1
Stress / posttraumatic stress disorder 2.2 1.8 0.22
Systemic Lupus Erythematosus 3.6 1.3 1.77
Tic Disorder 1.3 0.7 0.86
Tourette syndrome 0.3 0.2 0.5
Type 1 Diabetes 3.1 3.1 0
Type 2 Diabetes 5.8 6.4 -0.1
Ulcerative colitis 2.8 5 -0.79
Unhealthy Ageing 5.8 2.2 1.64

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