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Anticancer Effects: Gefitinib is classified as a tyrosine kinase inhibitor (TKI) that works by blocking the activity of the EGFR protein, which is involved in the growth and spread of cancer cells. By inhibiting EGFR signaling, gefitinib helps to slow down or stop the growth of cancer cells in the lungs.
EGFR Mutation: Gefitinib is most effective in patients with NSCLC who have EGFR mutations. These mutations make cancer cells more dependent on EGFR signaling for their growth and survival, making them more susceptible to gefitinib's inhibitory effects.
Improvement in Symptoms: Gefitinib treatment can lead to improvements in symptoms such as coughing, shortness of breath, and chest pain in patients with NSCLC. It may also improve overall quality of life by slowing disease progression.
Response Rate: In clinical trials, gefitinib has been shown to produce tumor responses in a subset of patients with NSCLC, including partial and complete responses. However, not all patients will respond to treatment, and response rates may vary depending on factors such as EGFR mutation status and disease stage.
Adverse Effects: Common side effects of gefitinib treatment include diarrhea, skin rash or acne, dry skin, nausea, vomiting, loss of appetite, fatigue, and nail changes. Most side effects are mild to moderate in severity and can often be managed with supportive care or dose adjustments.
Interstitial Lung Disease (ILD): Gefitinib has been associated with the development of ILD, a potentially serious side effect characterized by inflammation and scarring of lung tissue. Patients experiencing new or worsening respiratory symptoms such as cough, difficulty breathing, or fever should seek medical attention promptly.
Liver Toxicity: Gefitinib can affect liver function, leading to elevated liver enzyme levels in some patients. Regular monitoring of liver function tests is recommended during gefitinib treatment to detect and manage liver toxicity.
Cardiovascular Effects: Rarely, gefitinib treatment may be associated with cardiovascular side effects such as QT prolongation (a heart rhythm disorder) and thromboembolism (blood clots). Patients with preexisting cardiovascular risk factors should be monitored closely during treatment.
Drug Interactions: Gefitinib may interact with other medications, including certain antibiotics, antifungals, and anticonvulsants, which can affect its metabolism and efficacy. Patients should inform their healthcare provider about all medications they are taking before starting gefitinib treatment.
Pregnancy and Breastfeeding: Gefitinib can cause fetal harm if used during pregnancy, and women of childbearing potential should use effective contraception during treatment and for a period afterward. Breastfeeding is not recommended during gefitinib treatment due to the potential for adverse effects on the infant.
Patient Counseling: Patients receiving gefitinib should be counseled about the importance of adherence to treatment, management of side effects, and the need for regular medical monitoring. They should also be educated about signs and symptoms of potential complications such as ILD.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Lacticaseibacillus paracasei | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| ADHD | 2.4 | 0.5 | 3.8 |
| Age-Related Macular Degeneration and Glaucoma | 0.9 | 0.1 | 8 |
| Allergic Rhinitis (Hay Fever) | 1.2 | 1.2 | |
| Allergies | 2.8 | 1.9 | 0.47 |
| Allergy to milk products | 1.1 | 0.1 | 10 |
| Alopecia (Hair Loss) | 1.2 | 1.2 | |
| Alzheimer's disease | 2.4 | 6.9 | -1.88 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 2.7 | 0.5 | 4.4 |
| Ankylosing spondylitis | 1.8 | 1.8 | 0 |
| Anorexia Nervosa | 0.1 | 3 | -29 |
| Antiphospholipid syndrome (APS) | 1.5 | 1.5 | |
| Asthma | 0.3 | 0.7 | -1.33 |
| Atherosclerosis | 0.5 | 1.7 | -2.4 |
| Atrial fibrillation | 3.3 | 0.9 | 2.67 |
| Autism | 6.7 | 7.2 | -0.07 |
| Bipolar Disorder | 0.8 | 1.4 | -0.75 |
| Brain Trauma | 0 | 0.7 | 0 |
| Carcinoma | 1.9 | 1.9 | 0 |
| Celiac Disease | 0.6 | 2.3 | -2.83 |
| Cerebral Palsy | 0.3 | 1.7 | -4.67 |
| Chronic Fatigue Syndrome | 4 | 4.8 | -0.2 |
| Chronic Kidney Disease | 1.9 | 2.5 | -0.32 |
| Chronic Lyme | 0.7 | -0.7 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 1.4 | -1.4 | |
| Chronic Urticaria (Hives) | 0.3 | 1.3 | -3.33 |
| Coagulation / Micro clot triggering bacteria | 0.1 | 1.4 | -13 |
| Colorectal Cancer | 2 | 0.5 | 3 |
| Constipation | 1.1 | 0.9 | 0.22 |
| Coronary artery disease | 1.6 | 1 | 0.6 |
| COVID-19 | 5 | 11.5 | -1.3 |
| Crohn's Disease | 5 | 6 | -0.2 |
| cystic fibrosis | 0.7 | -0.7 | |
| deep vein thrombosis | 0.9 | -0.9 | |
| Depression | 5.8 | 6.1 | -0.05 |
| Eczema | 0.6 | 1 | -0.67 |
| Endometriosis | 1.8 | 1 | 0.8 |
| Epilepsy | 1.5 | 0.8 | 0.88 |
| Fibromyalgia | 1.8 | 2.8 | -0.56 |
| Functional constipation / chronic idiopathic constipation | 3.9 | 3.8 | 0.03 |
| gallstone disease (gsd) | 1.9 | 0.4 | 3.75 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 1 | 1 | 0 |
| Generalized anxiety disorder | 1.1 | 1.1 | 0 |
| giant cell arteritis | 0.3 | -0.3 | |
| Gout | 0.5 | -0.5 | |
| Graves' disease | 0.4 | 1.5 | -2.75 |
| Halitosis | 0.2 | 0.2 | |
| Hashimoto's thyroiditis | 2.7 | 0.2 | 12.5 |
| Histamine Issues,Mast Cell Issue, DAO Insufficiency | 1.9 | 1.4 | 0.36 |
| hypercholesterolemia (High Cholesterol) | 0.3 | 0.3 | |
| hyperglycemia | 0.8 | -0.8 | |
| Hyperlipidemia (High Blood Fats) | 0 | 0 | 0 |
| hypersomnia | 0.5 | -0.5 | |
| hypertension (High Blood Pressure | 0.9 | 3.1 | -2.44 |
| Hypothyroidism | 1 | -1 | |
| Hypoxia | 0.3 | 0.3 | |
| IgA nephropathy (IgAN) | 3.8 | -3.8 | |
| Inflammatory Bowel Disease | 1.5 | 8 | -4.33 |
| Insomnia | 0.7 | 1.2 | -0.71 |
| Intelligence | 1.5 | 0.6 | 1.5 |
| Intracranial aneurysms | 1.3 | 0 | 0 |
| Irritable Bowel Syndrome | 2 | 2.5 | -0.25 |
| Liver Cirrhosis | 3.1 | 2.5 | 0.24 |
| Long COVID | 5.2 | 7.4 | -0.42 |
| Low bone mineral density | 1.4 | -1.4 | |
| Lung Cancer | 1.5 | -1.5 | |
| ME/CFS with IBS | 1.3 | 3.2 | -1.46 |
| ME/CFS without IBS | 1 | 1.9 | -0.9 |
| Menopause | 0.2 | 0.2 | |
| Metabolic Syndrome | 4.5 | 5.5 | -0.22 |
| Mood Disorders | 7.4 | 6.1 | 0.21 |
| multiple chemical sensitivity [MCS] | 0.5 | -0.5 | |
| Multiple Sclerosis | 1.6 | 5.7 | -2.56 |
| Multiple system atrophy (MSA) | 0.7 | 1 | -0.43 |
| Neuropathy (all types) | 0.5 | 0.5 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 2 | 4.2 | -1.1 |
| Obesity | 6.5 | 3.3 | 0.97 |
| obsessive-compulsive disorder | 4.7 | 4.4 | 0.07 |
| Osteoarthritis | 1.1 | 0.5 | 1.2 |
| Osteoporosis | 1.1 | 0.7 | 0.57 |
| Parkinson's Disease | 0.6 | 4.6 | -6.67 |
| Polycystic ovary syndrome | 2 | 1.7 | 0.18 |
| Postural orthostatic tachycardia syndrome | 0.3 | 0.5 | -0.67 |
| Premenstrual dysphoric disorder | 0.5 | 0.1 | 4 |
| primary biliary cholangitis | 0.5 | 0.7 | -0.4 |
| Psoriasis | 3.1 | 2.1 | 0.48 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 4.6 | 2.7 | 0.7 |
| Rosacea | 1.5 | 0.7 | 1.14 |
| Schizophrenia | 3.5 | 2.2 | 0.59 |
| scoliosis | 0.5 | 1.5 | -2 |
| Sjögren syndrome | 1.2 | 2.5 | -1.08 |
| Sleep Apnea | 1.5 | 1.7 | -0.13 |
| Stress / posttraumatic stress disorder | 1.6 | 1.2 | 0.33 |
| Systemic Lupus Erythematosus | 2.6 | 1.9 | 0.37 |
| Tic Disorder | 0.9 | 1.1 | -0.22 |
| Tourette syndrome | 0.2 | -0.2 | |
| Type 1 Diabetes | 3 | 1.6 | 0.88 |
| Type 2 Diabetes | 4.5 | 5.2 | -0.16 |
| Ulcerative colitis | 2 | 3.4 | -0.7 |
| Unhealthy Ageing | 4.3 | 1.9 | 1.26 |
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