🍽️ trifluoperazine dihydrochloride,(prescription)

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  1. Schizophrenia and Psychotic Disorders:

    • Trifluoperazine dihydrochloride belongs to the class of medications known as typical antipsychotics or first-generation antipsychotics.
    • It is used for the management of schizophrenia, a chronic mental disorder characterized by distorted thinking, hallucinations, delusions, and abnormal social behavior.
    • Trifluoperazine helps alleviate symptoms by blocking dopamine receptors in the brain, thereby reducing the activity of dopamine, a neurotransmitter associated with psychosis.
    • It may also be prescribed for other psychotic disorders, including schizoaffective disorder and psychotic depression.
  2. Adjunctive Therapy:

    • In some cases, trifluoperazine dihydrochloride may be used as an adjunctive therapy alongside other medications or psychosocial interventions to enhance the overall management of psychiatric conditions.
  3. Dosage and Administration:

    • Trifluoperazine dihydrochloride is available in various formulations, including tablets and oral solution.
    • The dosage and frequency of administration depend on the patient's age, weight, medical condition, and response to treatment.
    • It is typically taken orally with or without food, as directed by a healthcare provider.
    • Dosage adjustments may be necessary based on individual patient factors and the severity of symptoms.
  4. Adverse Effects:

    • Common side effects of trifluoperazine dihydrochloride may include drowsiness, dizziness, dry mouth, blurred vision, constipation, urinary retention, weight gain, and extrapyramidal symptoms such as tremors, muscle stiffness, and tardive dyskinesia.
    • Some patients may experience orthostatic hypotension, a sudden drop in blood pressure upon standing up, which can cause dizziness or fainting.
    • Rare but serious adverse effects may include neuroleptic malignant syndrome (NMS), a potentially life-threatening condition characterized by fever, altered mental status, muscle rigidity, and autonomic dysfunction.
  5. Contraindications and Precautions:

    • Trifluoperazine dihydrochloride is contraindicated in patients with a known hypersensitivity to trifluoperazine or other phenothiazine derivatives.
    • It should be used with caution in elderly patients, individuals with cardiovascular disease, hepatic impairment, or renal insufficiency.
    • Trifluoperazine may lower the seizure threshold, so caution is advised in patients with a history of seizures or epilepsy.
  6. Drug Interactions:

    • Trifluoperazine may interact with other medications, including central nervous system depressants, anticholinergic drugs, antihypertensive agents, and certain antibiotics.
    • Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking to avoid potential interactions.
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Data Contradictions β€” Limits of Certainity

Impacted of trifluoperazine dihydrochloride,(prescription) On Probiotics

Rank Probiotic Impact
species Lacticaseibacillus paracasei Reduces

Bacteria Impacted by trifluoperazine dihydrochloride,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Segatella genus Decreases 👪 Source Study
Lachnospira genus Decreases 👪 Source Study
Roseburia genus Decreases 👪 Source Study
Agathobacter genus Decreases 👪 Source Study
Bilophila genus Decreases 👪 Source Study High Level Cause Brain Fog(Cognitive impairment)
Phocaeicola genus Decreases 👪 Source Study
Lacrimispora genus Decreases 👪 Source Study
Bacteroides genus Decreases 👪 Source Study
Blautia genus Decreases 👪 Source Study
Dorea genus Decreases 👪 Source Study
Lacticaseibacillus genus Decreases 👪 Source Study
Collinsella genus Decreases 👪 Source Study proinflammatory
Ruminococcus genus Decreases 👪 Source Study
Parabacteroides genus Decreases 👪 Source Study BMI, fat percent,blood pressure
Coprococcus genus Decreases 👪 Source Study
Odoribacter genus Decreases 👪 Source Study
Clostridioides genus Decreases 👪 Source Study
Streptococcus genus Decreases 👪 Source Study
Mediterraneibacter genus Decreases 👪 Source Study
Fusobacterium genus Decreases 👪 Source Study Periodontal disease, Lemierre syndrome, skin ulcers
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Negativicoccus no rank Decreases ⚗️ Source Study
Eggerthellales order Decreases ⚗️ Source Study
Roseburia hominis species Decreases 📓 Source Study
Segatella copri species Decreases 📓 Source Study Over 70%ile Indicator of mycotoxin present
Lachnospira eligens species Decreases 📓 Source Study
Parabacteroides distasonis species Decreases 📓 Source Study
Roseburia intestinalis species Decreases 📓 Source Study
Agathobacter rectalis species Decreases 📓 Source Study
Bilophila wadsworthia species Decreases 📓 Source Study
Phocaeicola vulgatus species Decreases 📓 Source Study
Lacrimispora saccharolytica species Decreases 📓 Source Study
Bacteroides uniformis species Decreases 📓 Source Study Infectious bacteria
Bacteroides fragilis species Decreases 📓 Source Study H02076 Bacteroides infection
Blautia obeum species Decreases 📓 Source Study
Dorea formicigenerans species Decreases 📓 Source Study
Bacteroides thetaiotaomicron species Decreases 📓 Source Study
Lacticaseibacillus paracasei species Decreases 📓 Source Study
Collinsella aerofaciens species Decreases 📓 Source Study
Ruminococcus bromii species Decreases 📓 Source Study
Coprococcus comes species Decreases 📓 Source Study
Parabacteroides merdae species Decreases 📓 Source Study Infectious bacteria
Odoribacter splanchnicus species Decreases 📓 Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Clostridioides difficile species Decreases 📓 Source Study Colitis
Negativicoccus sp. S5-A15 species Decreases ⚗️ Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Allisonella histaminiformans species Decreases ⚗️ Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Streptococcus salivarius species Decreases 📓 Source Study Infectious bacteria
[Ruminococcus] gnavus species Decreases 📓 Source Study
Fusobacterium nucleatum species Decreases 📓 Source Study Infectious bacteria
Coriobacterineae suborder Decreases ⚗️ Source Study
Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases 👶 Source Study
Fusobacterium nucleatum subsp. nucleatum subspecies Decreases 👶 Source Study
Chlamydiae/Verrucomicrobia group superphylum Decreases ⚗️ Source Study

Impact of trifluoperazine dihydrochloride,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.5 0.5
ADHD 2.8 0.2 13
Age-Related Macular Degeneration and Glaucoma 0.9 0.3 2
Allergic Rhinitis (Hay Fever) 0.8 0.8
Allergies 3.6 1.7 1.12
Allergy to milk products 0.8 0.3 1.67
Alopecia (Hair Loss) 2.2 2.2
Alzheimer's disease 3.2 6.8 -1.13
Amyotrophic lateral sclerosis (ALS) Motor Neuron 2.6 0.4 5.5
Ankylosing spondylitis 3.3 1.4 1.36
Anorexia Nervosa 0.3 2.7 -8
Antiphospholipid syndrome (APS) 1.8 0.5 2.6
Asthma 0.9 -0.9
Atherosclerosis 0.8 1.7 -1.13
Atrial fibrillation 3.2 2.3 0.39
Autism 5 8.6 -0.72
Barrett esophagus cancer 0 0 0
Bipolar Disorder 1.6 1 0.6
Brain Trauma 0.4 0.9 -1.25
Carcinoma 3 2.5 0.2
Celiac Disease 1.6 3.1 -0.94
Cerebral Palsy 0 1.7 0
Chronic Fatigue Syndrome 2.4 5.5 -1.29
Chronic Kidney Disease 0.8 2.5 -2.13
Chronic Lyme 0.9 -0.9
Chronic Obstructive Pulmonary Disease (COPD) 0.1 1.2 -11
Chronic Urticaria (Hives) 0 1.9 0
Coagulation / Micro clot triggering bacteria 0.3 1.3 -3.33
Colorectal Cancer 2.8 0.9 2.11
Constipation 1.9 0.9 1.11
Coronary artery disease 1.3 0.6 1.17
COVID-19 6.2 12.7 -1.05
Crohn's Disease 5.7 6.6 -0.16
cystic fibrosis 0.9 -0.9
deep vein thrombosis 0.9 -0.9
Depression 6.4 6.2 0.03
Dermatomyositis 0 0
Eczema 0.1 1.1 -10
Endometriosis 1.8 1 0.8
Eosinophilic Esophagitis 0 0
Epilepsy 2.3 1.4 0.64
Fibromyalgia 1.9 2.7 -0.42
Functional constipation / chronic idiopathic constipation 4.5 3.1 0.45
gallstone disease (gsd) 1.5 0.5 2
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 1.9 0.9 1.11
Generalized anxiety disorder 0.5 0.6 -0.2
Glioblastoma 0 0
Gout 0.2 -0.2
Graves' disease 1.1 1.7 -0.55
Halitosis 0.5 0 0
Hashimoto's thyroiditis 1.8 0.9 1
Hidradenitis Suppurativa 0.6 0.6
Histamine Issues,Mast Cell Issue, DAO Insufficiency 2.4 1 1.4
hypercholesterolemia (High Cholesterol) 0.1 0.1
hyperglycemia 1.2 -1.2
Hyperlipidemia (High Blood Fats) 0.4 0.4 0
hypersomnia 0.9 -0.9
hypertension (High Blood Pressure 1.5 4.1 -1.73
Hypothyroidism 0.6 -0.6
Hypoxia 0.8 0.8
IgA nephropathy (IgAN) 3.8 -3.8
Inflammatory Bowel Disease 2 9.3 -3.65
Insomnia 0.9 1.4 -0.56
Intelligence 1.1 1 0.1
Intracranial aneurysms 1.6 0.4 3
Irritable Bowel Syndrome 2.1 3.7 -0.76
Liver Cirrhosis 3.3 2.4 0.38
Long COVID 4.9 8.8 -0.8
Low bone mineral density 1.2 -1.2
Lung Cancer 1.2 -1.2
ME/CFS with IBS 0 2.5 0
ME/CFS without IBS 0.2 2.7 -12.5
Metabolic Syndrome 5.4 7.2 -0.33
Mood Disorders 7.8 6.2 0.26
multiple chemical sensitivity [MCS] 0.1 0.4 -3
Multiple Sclerosis 2.2 6.6 -2
Multiple system atrophy (MSA) 1 0.8 0.25
Neuropathy (all types) 0.5 0.5
neuropsychiatric disorders (PANDAS, PANS) 0.1 0.1
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 2.3 3.9 -0.7
Obesity 6.4 3.5 0.83
obsessive-compulsive disorder 5.9 3.1 0.9
Osteoarthritis 0.6 0.4 0.5
Osteoporosis 0.8 0.9 -0.13
pancreatic cancer 0.2 0.2
Parkinson's Disease 1.4 4.5 -2.21
Polycystic ovary syndrome 2.5 1.3 0.92
Postural orthostatic tachycardia syndrome 0.2 -0.2
Premenstrual dysphoric disorder 0.8 0.3 1.67
primary biliary cholangitis 0.4 1.3 -2.25
Psoriasis 3.4 3.4 0
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 5.9 3 0.97
Rosacea 0.4 0.5 -0.25
Schizophrenia 3.7 1.4 1.64
scoliosis 0.2 1.9 -8.5
Sjögren syndrome 1.9 3.1 -0.63
Sleep Apnea 1 1.5 -0.5
Small Intestinal Bacterial Overgrowth (SIBO) 0.1 0.1
Stress / posttraumatic stress disorder 1.7 1.5 0.13
Systemic Lupus Erythematosus 3 1.9 0.58
Tic Disorder 1.4 1.9 -0.36
Tourette syndrome 0.5 -0.5
Type 1 Diabetes 3.8 2 0.9
Type 2 Diabetes 6.4 6.4 0
Ulcerative colitis 1.7 4.9 -1.88
Unhealthy Ageing 3.4 1.8 0.89

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