🍽️ promethazine hydrochloride,(prescription)

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  1. Antiemetic Effects: Promethazine hydrochloride is commonly used as an antiemetic medication to prevent and alleviate nausea and vomiting associated with surgery, anesthesia, chemotherapy, radiation therapy, and certain medical conditions.

  2. Antihistaminic Effects: Promethazine hydrochloride possesses antihistaminic properties, making it effective in managing symptoms of allergies, such as itching, sneezing, runny nose, and watery eyes.

  3. Motion Sickness: Promethazine hydrochloride is often prescribed to prevent and relieve symptoms of motion sickness, including nausea, vomiting, and dizziness during travel.

  4. Sedative and Sleep Aid: Due to its sedative effects, promethazine hydrochloride is sometimes used as a sleep aid in individuals experiencing difficulty falling asleep or maintaining sleep.

  5. Treatment of Cough: In some formulations, promethazine hydrochloride is combined with other medications to suppress cough associated with the common cold or respiratory tract infections.

  6. Potentiation of Analgesics: Promethazine hydrochloride can enhance the analgesic effects of certain pain medications when used in combination, particularly opioids.

  7. Side Effects: Common side effects of promethazine hydrochloride may include drowsiness, dizziness, blurred vision, dry mouth, constipation, and urinary retention. These side effects are usually mild and transient but may require medical attention if they persist or worsen.

  8. Respiratory Depression: Promethazine hydrochloride, especially when used in high doses or in combination with other central nervous system depressants such as opioids, may cause respiratory depression, which can be life-threatening.

  9. Extrapyramidal Symptoms: In rare cases, promethazine hydrochloride may cause extrapyramidal symptoms such as dystonia, akathisia, parkinsonism, and tardive dyskinesia, particularly with long-term use or in susceptible individuals.

  10. Hypersensitivity Reactions: Some individuals may experience allergic reactions to promethazine hydrochloride, ranging from mild rash and itching to severe anaphylaxis. Patients should seek immediate medical attention if they develop signs of an allergic reaction after taking this medication.

  11. Drug Interactions: Promethazine hydrochloride may interact with other medications, including other central nervous system depressants, anticholinergic agents, and certain antidepressants, leading to additive sedative effects or other adverse reactions.

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βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of promethazine hydrochloride,(prescription) On Probiotics

Rank Probiotic Impact
species Akkermansia muciniphila Reduces
species Escherichia coli Reduces

Bacteria Impacted by promethazine hydrochloride,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Akkermansiaceae family Decreases 👪 Source Study
Phocaeicola genus Decreases 👪 Source Study
Parabacteroides genus Decreases 👪 Source Study BMI, fat percent,blood pressure
Akkermansia genus Decreases 📓 Source Study
Odoribacter genus Decreases 👪 Source Study
Agathobacter genus Decreases 👪 Source Study
Coprococcus genus Decreases 👪 Source Study
Lachnospira genus Decreases 👪 Source Study
Bacteroides genus Decreases 👪 Source Study
Segatella genus Decreases 👪 Source Study
Escherichia genus Decreases 👪 Source Study
Eggerthella genus Decreases 👪 Source Study
Roseburia genus Decreases 👪 Source Study
Ruminococcus genus Decreases 👪 Source Study
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
unclassified Negativicoccus no rank Decreases ⚗️ Source Study
environmental samples no rank Decreases 👶 Source Study
unclassified Akkermansia no rank Decreases 👶 Source Study
Escherichia coli O80:H26 no rank Decreases 👶 Source Study
Eggerthellales order Decreases ⚗️ Source Study
Escherichia coli O145 serogroup Decreases 👶 Source Study
Escherichia coli O157 serogroup Decreases 👶 Source Study
Escherichia coli O26 serogroup Decreases 👶 Source Study
Escherichia coli O43 serogroup Decreases 👶 Source Study
Escherichia coli O1:H42 serotype Decreases 👶 Source Study
Escherichia coli O104:H4 serotype Decreases 👶 Source Study
Escherichia coli O121:H19 serotype Decreases 👶 Source Study
Escherichia coli O127:H6 serotype Decreases 👶 Source Study
Escherichia coli O139:H28 serotype Decreases 👶 Source Study
Escherichia coli O157:H7 serotype Decreases 👶 Source Study bloody diarrhea
Escherichia coli O44:H18 serotype Decreases 👶 Source Study
Escherichia coli O55:H7 serotype Decreases 👶 Source Study
Escherichia coli O6:H16 serotype Decreases 👶 Source Study
Escherichia coli O7:K1 serotype Decreases 👶 Source Study
Parabacteroides merdae species Decreases 📓 Source Study Infectious bacteria
Phocaeicola vulgatus species Decreases 📓 Source Study
Parabacteroides distasonis species Decreases 📓 Source Study
Bacteroides uniformis species Decreases 📓 Source Study Infectious bacteria
Akkermansia muciniphila species Decreases 📓 Source Study
Odoribacter splanchnicus species Decreases 📓 Source Study
Bacteroides fragilis species Decreases 📓 Source Study H02076 Bacteroides infection
Agathobacter rectalis species Decreases 📓 Source Study
Coprococcus comes species Decreases 📓 Source Study
Bacteroides thetaiotaomicron species Decreases 📓 Source Study
Lachnospira eligens species Decreases 📓 Source Study
Segatella copri species Decreases 📓 Source Study Over 70%ile Indicator of mycotoxin present
Bacteroides ovatus species Decreases 📓 Source Study
Escherichia coli species Decreases 📓 Source Study Diarrheal disease in children and travelers, Foodborne diarrhea outbreaks, hemorrhagic colitis, hemolytic-uremic syndrome
Eggerthella lenta species Decreases 📓 Source Study
Roseburia intestinalis species Decreases 📓 Source Study
Ruminococcus bromii species Decreases 📓 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Negativicoccus sp. S5-A15 species Decreases ⚗️ Source Study
Akkermansia glycaniphila species Decreases 👶 Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Bacteroides caccae species Decreases 📓 Source Study
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Coriobacterineae suborder Decreases ⚗️ Source Study

Impact of promethazine hydrochloride,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
ADHD 3.2 0.6 4.33
Age-Related Macular Degeneration and Glaucoma 0.1 0.5 -4
Allergic Rhinitis (Hay Fever) 1 1
Allergies 1.5 1.8 -0.2
Allergy to milk products 0.8 0.7 0.14
Alopecia (Hair Loss) 1 1
Alzheimer's disease 2.6 3.6 -0.38
Amyotrophic lateral sclerosis (ALS) Motor Neuron 4.3 1.5 1.87
Ankylosing spondylitis 2.2 0.8 1.75
Anorexia Nervosa 0.5 1.4 -1.8
Antiphospholipid syndrome (APS) 1.5 1.5
Asthma 0.4 2 -4
Atherosclerosis 0.1 1.9 -18
Atrial fibrillation 2.2 1.7 0.29
Autism 5.7 7.7 -0.35
benign prostatic hyperplasia 0.2 0.2
Biofilm 0.4 0.4
Bipolar Disorder 1.1 0.8 0.38
Brain Trauma 0.5 -0.5
Cancer (General) 0.5 0.1 4
Carcinoma 1.8 1.4 0.29
Celiac Disease 2.2 2.3 -0.05
Cerebral Palsy 0.5 0.6 -0.2
Chronic Fatigue Syndrome 3.3 6.4 -0.94
Chronic Kidney Disease 1.2 1.8 -0.5
Chronic Lyme 0.5 -0.5
Chronic Obstructive Pulmonary Disease (COPD) 0.9 -0.9
Chronic Urticaria (Hives) 0.6 2.6 -3.33
Coagulation / Micro clot triggering bacteria 1.1 0.2 4.5
Colorectal Cancer 3.1 0.4 6.75
Constipation 1.9 0.1 18
Coronary artery disease 0.5 0.4 0.25
COVID-19 6.9 10.3 -0.49
Crohn's Disease 5.2 5.4 -0.04
cystic fibrosis 0.6 0.5 0.2
deep vein thrombosis 0.6 0.2 2
Depression 6.7 6.3 0.06
Eczema 0.2 1 -4
Endometriosis 1.8 0.9 1
Epilepsy 2 3.3 -0.65
Fibromyalgia 1.6 2.8 -0.75
Functional constipation / chronic idiopathic constipation 4.7 2.6 0.81
gallstone disease (gsd) 0.8 0.1 7
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 2 2
Generalized anxiety disorder 0.6 0.8 -0.33
Gout 0.4 -0.4
Graves' disease 0.8 0.1 7
Halitosis 0.3 0.3
Hashimoto's thyroiditis 1 0.3 2.33
High Histamine/low DAO 0.5 0.1 4
hypercholesterolemia (High Cholesterol) 0.5 1 -1
hyperglycemia 0.4 2.3 -4.75
Hyperlipidemia (High Blood Fats) 0.5 0.5
hypertension (High Blood Pressure 1.6 3.7 -1.31
Hypothyroidism 0.6 -0.6
Hypoxia 1.3 1.3
IgA nephropathy (IgAN) 3.8 -3.8
Inflammatory Bowel Disease 2 7.2 -2.6
Insomnia 0.3 0.8 -1.67
Intelligence 1.4 0.6 1.33
Intracranial aneurysms 0.9 0.9
Irritable Bowel Syndrome 3.1 4.9 -0.58
Liver Cirrhosis 2.7 1.5 0.8
Long COVID 5.8 4.5 0.29
Low bone mineral density 0.9 -0.9
Lung Cancer 0.3 1.1 -2.67
Mast Cell Issues / mastitis 0.2 0.5 -1.5
ME/CFS with IBS 1.2 -1.2
ME/CFS without IBS 0.7 1.3 -0.86
Menopause 0.6 0.6
Metabolic Syndrome 4.3 6.4 -0.49
Mood Disorders 8.3 6.5 0.28
multiple chemical sensitivity [MCS] 0.5 0.5
Multiple Sclerosis 2.6 5.3 -1.04
Multiple system atrophy (MSA) 1.5 0.1 14
neuropathic pain 1.2 -1.2
Neuropathy (all types) 0.5 0.2 1.5
neuropsychiatric disorders (PANDAS, PANS) 0.9 0.9
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.8 3.6 -3.5
Obesity 3.5 3.3 0.06
obsessive-compulsive disorder 5.5 3.3 0.67
Osteoarthritis 0.5 0.1 4
Osteoporosis 0.8 1.3 -0.63
pancreatic cancer 0.5 0.5
Parkinson's Disease 3.2 2.9 0.1
Polycystic ovary syndrome 2.1 1.3 0.62
Postural orthostatic tachycardia syndrome 0.4 -0.4
Premenstrual dysphoric disorder 0.5 -0.5
primary biliary cholangitis 1 -1
Psoriasis 1.9 4 -1.11
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 3.4 2.3 0.48
Rosacea 0.1 0.1 0
Schizophrenia 4.4 0.7 5.29
scoliosis 0.4 0.8 -1
Sjögren syndrome 1.8 2.3 -0.28
Sleep Apnea 0.5 1.1 -1.2
Slow gastric motility / Gastroparesis 0.8 0.8
Small Intestinal Bacterial Overgrowth (SIBO) 0.4 0.4
Stress / posttraumatic stress disorder 1.9 2.3 -0.21
Systemic Lupus Erythematosus 3.1 1.1 1.82
Tic Disorder 1.6 0.6 1.67
Tourette syndrome 0.5 0.3 0.67
Type 1 Diabetes 3.6 1.5 1.4
Type 2 Diabetes 5.3 7.1 -0.34
Ulcerative colitis 0.9 6.6 -6.33
Unhealthy Ageing 2.9 2.4 0.21

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