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🍽️ oxolinic acid (antibiotic)

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  1. Urinary Tract Infections (UTIs): Oxolinic acid is effective against urinary tract infections caused by susceptible strains of bacteria, including Escherichia coli, Proteus mirabilis, Klebsiella species, Enterobacter species, and other gram-negative bacteria. It is particularly useful in treating uncomplicated lower urinary tract infections such as cystitis.

  2. Prostatitis: Oxolinic acid may also be used in the treatment of bacterial prostatitis, which is an inflammation of the prostate gland often caused by bacterial infection. It can help eradicate the bacteria responsible for the infection and alleviate symptoms such as pain, urinary frequency, and discomfort.

  3. Gastrointestinal Infections: In some cases, oxolinic acid may be prescribed for the treatment of gastrointestinal infections caused by susceptible bacteria. However, its use in this context is less common compared to other antibiotics.

  4. Other Infections: Oxolinic acid may also be used to treat other bacterial infections caused by susceptible organisms, though its use is primarily limited to urinary tract infections and prostatitis.

  5. Mechanism of Action: Oxolinic acid works by inhibiting the bacterial DNA gyrase enzyme, thereby interfering with the replication and transcription of bacterial DNA. This ultimately leads to bacterial cell death and eradication of the infection.

  6. Dosage and Administration: The dosage of oxolinic acid depends on the severity of the infection, the specific bacteria causing the infection, and the patient's renal function. It is typically administered orally in the form of tablets or capsules. The dosage regimen should be determined by a healthcare professional based on individual factors.

  7. Adverse Effects: Common side effects of oxolinic acid may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal pain. Additionally, allergic reactions and skin rashes may occur in some individuals. Rare but serious adverse effects may include tendon rupture, central nervous system effects (such as dizziness or confusion), and photosensitivity reactions.

  8. Precautions: Oxolinic acid should be used with caution in patients with a history of tendon disorders, as it may increase the risk of tendon rupture. It should also be used cautiously in patients with epilepsy or other seizure disorders, as quinolone antibiotics may lower the seizure threshold.

  9. Drug Interactions: Oxolinic acid may interact with certain medications, supplements, or herbal products, potentially affecting its efficacy or increasing the risk of adverse effects. It is important to inform a healthcare professional about all medications being taken before starting treatment with oxolinic acid.

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Check for interactions on Supp.AI   |   πŸ“š PubMed Citations

βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of oxolinic acid (antibiotic) On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Bacteroides uniformis Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium longum Reduces
species Escherichia coli Reduces
species Lacticaseibacillus paracasei Reduces
species Parabacteroides distasonis Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by oxolinic acid (antibiotic)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Clostridium genus Decreases 👪 Source Study Pathogen
Escherichia genus Decreases 👪 Source Study
Veillonella genus Decreases 👪 Source Study
Clostridioides genus Decreases 👪 Source Study
Bacteroides genus Decreases 👪 Source Study
Eggerthella genus Decreases 👪 Source Study
Phocaeicola genus Decreases 👪 Source Study
Bilophila genus Decreases 👪 Source Study High Level Cause Brain Fog(Cognitive impairment)
Lacticaseibacillus genus Decreases 👪 Source Study
Odoribacter genus Decreases 👪 Source Study
Bifidobacterium genus Decreases 👪 Source Study
Thomasclavelia genus Decreases 👪 Source Study
Enterocloster genus Decreases 👪 Source Study
Blautia genus Decreases 👪 Source Study
Dorea genus Decreases 👪 Source Study
Collinsella genus Decreases 👪 Source Study proinflammatory
Lacrimispora genus Decreases 👪 Source Study
Agathobacter genus Decreases 👪 Source Study
Ruminococcus genus Decreases 👪 Source Study
Parabacteroides genus Decreases 👪 Source Study BMI, fat percent,blood pressure
Roseburia genus Decreases 👪 Source Study
Streptococcus genus Decreases 👪 Source Study
Segatella genus Decreases 👪 Source Study
Lachnospira genus Decreases 👪 Source Study
Coprococcus genus Decreases 👪 Source Study
Clostridium perfringens A no rank Decreases 👶 Source Study
Clostridium perfringens B no rank Decreases 👶 Source Study
Clostridium perfringens D no rank Decreases 👶 Source Study
Clostridium perfringens E no rank Decreases 👶 Source Study
Escherichia coli O1:K1:H7 no rank Decreases 👶 Source Study
Escherichia coli O139:H1 no rank Decreases 👶 Source Study
Escherichia coli O141:H4 no rank Decreases 👶 Source Study
Escherichia coli O145:H34 no rank Decreases 👶 Source Study
Escherichia coli O15:H12 no rank Decreases 👶 Source Study
Escherichia coli O155:H21 no rank Decreases 👶 Source Study
Escherichia coli O158:H23 no rank Decreases 👶 Source Study
Escherichia coli O16:H48 no rank Decreases 👶 Source Study
Escherichia coli O170:H18 no rank Decreases 👶 Source Study
Escherichia coli O18ac:H14 no rank Decreases 👶 Source Study
Escherichia coli O19:H7 no rank Decreases 👶 Source Study
Escherichia coli O2:K1:H4 no rank Decreases 👶 Source Study
Escherichia coli O2:K1:H5 no rank Decreases 👶 Source Study
Escherichia coli O2:K1:H7 no rank Decreases 👶 Source Study
Escherichia coli O20:H12 no rank Decreases 👶 Source Study
Escherichia coli O25:H16 no rank Decreases 👶 Source Study
Escherichia coli O55:H7 no rank Decreases 👶 Source Study
Escherichia coli O68:H12 no rank Decreases 👶 Source Study
Escherichia coli O7:H15 no rank Decreases 👶 Source Study
Escherichia coli O78:H51 no rank Decreases 👶 Source Study
Escherichia coli O80:H26 no rank Decreases 👶 Source Study
Escherichia coli O84:H7 no rank Decreases 👶 Source Study
Escherichia coli O85:H1 no rank Decreases 👶 Source Study
Escherichia coli O121 serogroup Decreases 👶 Source Study
Escherichia coli O145 serogroup Decreases 👶 Source Study
Escherichia coli O155 serogroup Decreases 👶 Source Study
Escherichia coli O157 serogroup Decreases 👶 Source Study
Escherichia coli O177 serogroup Decreases 👶 Source Study
Escherichia coli O26 serogroup Decreases 👶 Source Study
Escherichia coli O3 serogroup Decreases 👶 Source Study
Escherichia coli O43 serogroup Decreases 👶 Source Study
Escherichia coli O78 serogroup Decreases 👶 Source Study
Escherichia coli O86 serogroup Decreases 👶 Source Study
Escherichia coli O91 serogroup Decreases 👶 Source Study
Escherichia coli H20 serotype Decreases 👶 Source Study
Escherichia coli O1:H42 serotype Decreases 👶 Source Study
Escherichia coli O1:HNT serotype Decreases 👶 Source Study
Escherichia coli O10:H32 serotype Decreases 👶 Source Study
Escherichia coli O100:H21 serotype Decreases 👶 Source Study
Escherichia coli O103:H2 serotype Decreases 👶 Source Study
Escherichia coli O104:H4 serotype Decreases 👶 Source Study
Escherichia coli O111:H- serotype Decreases 👶 Source Study
Escherichia coli O111:H8 serotype Decreases 👶 Source Study
Escherichia coli O111:NM serotype Decreases 👶 Source Study
Escherichia coli O112ab:H8 serotype Decreases 👶 Source Study
Escherichia coli O112ac:H19 serotype Decreases 👶 Source Study
Escherichia coli O113:H21 serotype Decreases 👶 Source Study
Escherichia coli O114:H49 serotype Decreases 👶 Source Study
Escherichia coli O121:H19 serotype Decreases 👶 Source Study
Escherichia coli O125ac:K+:H10 serotype Decreases 👶 Source Study
Escherichia coli O126:H45 serotype Decreases 👶 Source Study
Escherichia coli O127:H6 serotype Decreases 👶 Source Study
Escherichia coli O128ac:H12 serotype Decreases 👶 Source Study
Escherichia coli O139:H28 serotype Decreases 👶 Source Study
Escherichia coli O145:H25 serotype Decreases 👶 Source Study
Escherichia coli O145:H28 serotype Decreases 👶 Source Study
Escherichia coli O145:NM serotype Decreases 👶 Source Study
Escherichia coli O15:H18 serotype Decreases 👶 Source Study
Escherichia coli O150:H6 serotype Decreases 👶 Source Study
Escherichia coli O152:H23 serotype Decreases 👶 Source Study
Escherichia coli O157:H- serotype Decreases 👶 Source Study
Escherichia coli O157:H43 serotype Decreases 👶 Source Study
Escherichia coli O157:H7 serotype Decreases 👶 Source Study bloody diarrhea
Escherichia coli O16:H6 serotype Decreases 👶 Source Study
Escherichia coli O167:H26 serotype Decreases 👶 Source Study
Escherichia coli O174:H21 serotype Decreases 👶 Source Study
Escherichia coli O176:H45 serotype Decreases 👶 Source Study
Escherichia coli O2:H6 serotype Decreases 👶 Source Study
Escherichia coli O2:K2:H1 serotype Decreases 👶 Source Study
Escherichia coli O25:H1 serotype Decreases 👶 Source Study
Escherichia coli O25:NM serotype Decreases 👶 Source Study
Escherichia coli O26:H11 serotype Decreases 👶 Source Study
Escherichia coli O44:H18 serotype Decreases 👶 Source Study
Escherichia coli O45:H2 serotype Decreases 👶 Source Study
Escherichia coli O6:H16 serotype Decreases 👶 Source Study
Escherichia coli O6:K2:H1 serotype Decreases 👶 Source Study
Escherichia coli O7:H4 serotype Decreases 👶 Source Study
Escherichia coli O7:K1 serotype Decreases 👶 Source Study
Escherichia coli O78:H4 serotype Decreases 👶 Source Study
Escherichia coli O8:H8 serotype Decreases 👶 Source Study
Escherichia coli O89m:H10 serotype Decreases 👶 Source Study
Escherichia coli O89m:H9 serotype Decreases 👶 Source Study
Escherichia coli O9:H10 serotype Decreases 👶 Source Study
Escherichia coli O99:H6 serotype Decreases 👶 Source Study
Clostridium perfringens species Decreases 📓 Source Study Food poisoning, gas gangrene
Escherichia coli species Decreases 📓 Source Study Diarrheal disease in children and travelers, Foodborne diarrhea outbreaks, hemorrhagic colitis, hemolytic-uremic syndrome
Bacteroides xylanisolvens species Decreases 📓 Source Study
Bacteroides ovatus species Decreases 📓 Source Study
Veillonella parvula species Decreases 📓 Source Study
Clostridioides difficile species Decreases 📓 Source Study Colitis
Bacteroides caccae species Decreases 📓 Source Study
Bacteroides thetaiotaomicron species Decreases 📓 Source Study
Eggerthella lenta species Decreases 📓 Source Study
Phocaeicola vulgatus species Decreases 📓 Source Study
Bilophila wadsworthia species Decreases 📓 Source Study
Bifidobacterium adolescentis species Decreases 📓 Source Study
Lacticaseibacillus paracasei species Decreases 📓 Source Study
Odoribacter splanchnicus species Decreases 📓 Source Study
Thomasclavelia ramosa species Decreases 📓 Source Study
Bacteroides fragilis species Decreases 📓 Source Study H02076 Bacteroides infection
Enterocloster bolteae species Decreases 📓 Source Study
Blautia obeum species Decreases 📓 Source Study
Dorea formicigenerans species Decreases 📓 Source Study
Bifidobacterium longum species Decreases 📓 Source Study
Collinsella aerofaciens species Decreases 📓 Source Study
Lacrimispora saccharolytica species Decreases 📓 Source Study
Roseburia hominis species Decreases 📓 Source Study
Agathobacter rectalis species Decreases 📓 Source Study
Bacteroides uniformis species Decreases 📓 Source Study Infectious bacteria
Streptococcus parasanguinis species Decreases 📓 Source Study
Ruminococcus bromii species Decreases 📓 Source Study
Parabacteroides distasonis species Decreases 📓 Source Study
Parabacteroides merdae species Decreases 📓 Source Study Infectious bacteria
Roseburia intestinalis species Decreases 📓 Source Study
Streptococcus salivarius species Decreases 📓 Source Study Infectious bacteria
Segatella copri species Decreases 📓 Source Study Over 70%ile Indicator of mycotoxin present
Lachnospira eligens species Decreases 📓 Source Study
Coprococcus comes species Decreases 📓 Source Study
Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases 👶 Source Study
Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. infantis subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. longum subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. suillum subspecies Decreases 👶 Source Study

Impact of oxolinic acid (antibiotic) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.4 0.4
Acne 0.3 -0.3
ADHD 4.1 0.4 9.25
Age-Related Macular Degeneration and Glaucoma 0.5 0.2 1.5
Allergic Rhinitis (Hay Fever) 1.6 1.7 -0.06
Allergies 5.3 1.7 2.12
Allergy to milk products 2.1 1 1.1
Alopecia (Hair Loss) 1.3 1.3
Alzheimer's disease 3.2 4.9 -0.53
Amyotrophic lateral sclerosis (ALS) Motor Neuron 2.2 1.2 0.83
Ankylosing spondylitis 3.7 0.6 5.17
Anorexia Nervosa 0.2 1.8 -8
Antiphospholipid syndrome (APS) 2.2 0.4 4.5
Asthma 1.6 0.6 1.67
Atherosclerosis 0.8 1.5 -0.88
Atrial fibrillation 2.5 1.8 0.39
Autism 8 7.1 0.13
Barrett esophagus cancer 0.5 0.1 4
benign prostatic hyperplasia 0.5 0.5
Biofilm 1.4 1.4
Bipolar Disorder 1.6 1.2 0.33
Brain Trauma 0.6 0.6 0
Cancer (General) 0.3 4.2 -13
Carcinoma 3.7 2.3 0.61
Celiac Disease 3.1 3.5 -0.13
Cerebral Palsy 1.4 1.1 0.27
Chronic Fatigue Syndrome 7.3 6.2 0.18
Chronic Kidney Disease 1.5 0.9 0.67
Chronic Lyme 0.6 -0.6
Chronic Obstructive Pulmonary Disease (COPD) 1.1 0.2 4.5
Chronic Urticaria (Hives) 2.6 0.7 2.71
Coagulation / Micro clot triggering bacteria 1.8 0.8 1.25
Colorectal Cancer 3.8 0.8 3.75
Constipation 1.7 0.5 2.4
Coronary artery disease 0.7 0.8 -0.14
COVID-19 11.9 11.1 0.07
Crohn's Disease 6.8 3.6 0.89
cystic fibrosis 1.5 0.9 0.67
deep vein thrombosis 1.5 0.5 2
Depression 9.5 6.2 0.53
Dermatomyositis 0.1 0.3 -2
Eczema 1 1.6 -0.6
Endometriosis 3.1 1 2.1
Eosinophilic Esophagitis 0.5 -0.5
Epilepsy 2.6 1.5 0.73
Fibromyalgia 2.4 1.7 0.41
Functional constipation / chronic idiopathic constipation 6.2 3 1.07
gallstone disease (gsd) 2.4 0.5 3.8
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 1.9 0.7 1.71
Generalized anxiety disorder 1.8 1.9 -0.06
giant cell arteritis 0.5 -0.5
Glioblastoma 0.1 -0.1
Gout 0 0
Graves' disease 1.2 1 0.2
Halitosis 0.9 0.1 8
Hashimoto's thyroiditis 1.5 1.1 0.36
Hidradenitis Suppurativa 0.5 0.5 0
High Histamine/low DAO 2.7 0.5 4.4
hypercholesterolemia (High Cholesterol) 0.8 0.8
hyperglycemia 0.5 1.2 -1.4
Hyperlipidemia (High Blood Fats) 0.6 0.3 1
hypersomnia 0.7 -0.7
hypertension (High Blood Pressure 2 5.4 -1.7
Hypothyroidism 1 -1
Hypoxia 0.6 0.6
IgA nephropathy (IgAN) 3.2 -3.2
Inflammatory Bowel Disease 4.4 5.3 -0.2
Insomnia 0.8 0.6 0.33
Intelligence 0.9 0.1 8
Intracranial aneurysms 1.1 0.3 2.67
Irritable Bowel Syndrome 5.4 3.7 0.46
Liver Cirrhosis 4.2 2.9 0.45
Long COVID 7.5 6.9 0.09
Low bone mineral density 0.2 -0.2
Lung Cancer 1.4 0.8 0.75
Mast Cell Issues / mastitis 0.6 0.5 0.2
ME/CFS with IBS 1.2 2 -0.67
ME/CFS without IBS 1.8 2 -0.11
Menopause 2.3 2.3
Metabolic Syndrome 7.5 7.1 0.06
Mood Disorders 12.3 6.6 0.86
multiple chemical sensitivity [MCS] 0.7 0.3 1.33
Multiple Sclerosis 4 4 0
Multiple system atrophy (MSA) 0.9 0.8 0.13
neuropathic pain 1.1 -1.1
Neuropathy (all types) 0.4 0.5 -0.25
neuropsychiatric disorders (PANDAS, PANS) 1.3 1.3
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 2 4 -1
NonCeliac Gluten Sensitivity 1.3 0.7 0.86
Obesity 6.9 3.1 1.23
obsessive-compulsive disorder 7.4 2 2.7
Osteoarthritis 2.2 0.2 10
Osteoporosis 2.5 0.7 2.57
pancreatic cancer 0.5 0.5
Parkinson's Disease 5.9 4.8 0.23
Polycystic ovary syndrome 2.8 1.7 0.65
Postural orthostatic tachycardia syndrome 0.5 0.4 0.25
Premenstrual dysphoric disorder 0.9 0.2 3.5
primary biliary cholangitis 0.3 0.7 -1.33
Psoriasis 4.7 1.2 2.92
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 4.1 3.4 0.21
Rosacea 0.5 0.7 -0.4
Schizophrenia 6.7 1.5 3.47
scoliosis 0 0.6 0
Sjögren syndrome 2.9 2.9 0
Sleep Apnea 0.8 1.3 -0.63
Slow gastric motility / Gastroparesis 2.1 0.3 6
Small Intestinal Bacterial Overgrowth (SIBO) 1.1 0.6 0.83
Stress / posttraumatic stress disorder 2.9 2 0.45
Systemic Lupus Erythematosus 3.7 1.3 1.85
Tic Disorder 1.3 1 0.3
Tourette syndrome 0.4 -0.4
Type 1 Diabetes 4.7 2.3 1.04
Type 2 Diabetes 7.8 6.4 0.22
Ulcerative colitis 3.8 4.5 -0.18
Unhealthy Ageing 4.8 1.3 2.69
Vitiligo 1.3 1 0.3

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