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Mitochondrial Disorders: Idebenone has shown promise in the treatment of mitochondrial disorders, which are characterized by impaired mitochondrial function and energy production. It acts as a mitochondrial electron carrier and may help improve mitochondrial respiration and ATP synthesis, thereby potentially alleviating symptoms associated with mitochondrial dysfunction.
Friedreich's Ataxia: Friedreich's ataxia is a genetic neurodegenerative disorder characterized by progressive loss of coordination, muscle weakness, and other neurological symptoms. Idebenone has been studied as a potential treatment for Friedreich's ataxia due to its antioxidant properties and ability to enhance mitochondrial function. Clinical trials have suggested that idebenone may slow the progression of the disease and improve cardiac function in some patients.
Leber's Hereditary Optic Neuropathy (LHON): LHON is a rare genetic disorder that primarily affects the optic nerve, leading to vision loss and blindness. Idebenone has been investigated as a potential treatment for LHON due to its ability to improve mitochondrial function and reduce oxidative stress. Clinical trials have shown that idebenone may help preserve vision and improve visual acuity in some patients with LHON, particularly when administered early in the course of the disease.
Duchenne Muscular Dystrophy (DMD): DMD is a progressive muscle-wasting disorder caused by mutations in the dystrophin gene. Idebenone has been studied as a potential treatment for DMD due to its antioxidant and mitochondrial-stabilizing effects. Clinical trials have shown mixed results regarding the efficacy of idebenone in slowing the progression of DMD, with some studies reporting improvements in respiratory function and muscle strength, while others have not shown significant benefits.
Neuroprotection: Idebenone's antioxidant properties may confer neuroprotective effects, potentially reducing neuronal damage and promoting neuronal survival in various neurological conditions characterized by oxidative stress, inflammation, and mitochondrial dysfunction.
Adverse Effects: Common adverse effects associated with idebenone include gastrointestinal disturbances (e.g., nausea, diarrhea, abdominal discomfort), headache, dizziness, and rash. Serious adverse effects are rare but may include liver toxicity and allergic reactions.
Drug Interactions: Idebenone may interact with certain medications, supplements, or herbal products. Patients should inform their healthcare providers about all medications and supplements they are taking before starting idebenone therapy.
Pregnancy and Lactation: The safety of idebenone use during pregnancy and lactation has not been established. Pregnant or breastfeeding individuals should consult their healthcare providers before using idebenone.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Lacticaseibacillus paracasei | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| ADHD | 1.7 | 0.4 | 3.25 |
| Age-Related Macular Degeneration and Glaucoma | 0.3 | 0.5 | -0.67 |
| Allergic Rhinitis (Hay Fever) | 1.1 | 1.1 | |
| Allergies | 0.5 | 1.5 | -2 |
| Allergy to milk products | 1.2 | 0.5 | 1.4 |
| Alopecia (Hair Loss) | 1 | 1 | |
| Alzheimer's disease | 1.2 | 2.6 | -1.17 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 1.3 | 0.5 | 1.6 |
| Ankylosing spondylitis | 1.4 | 0.8 | 0.75 |
| Anorexia Nervosa | 0.5 | 1.6 | -2.2 |
| Antiphospholipid syndrome (APS) | 0.9 | 0.9 | |
| Asthma | 0.5 | 0.4 | 0.25 |
| Atherosclerosis | 0.5 | 1.3 | -1.6 |
| Atrial fibrillation | 2.1 | 0.6 | 2.5 |
| Autism | 4.5 | 3.9 | 0.15 |
| Barrett esophagus cancer | 0.4 | -0.4 | |
| Bipolar Disorder | 1.1 | 1.2 | -0.09 |
| Brain Trauma | 0.4 | -0.4 | |
| Carcinoma | 1.5 | 1.1 | 0.36 |
| Celiac Disease | 0.8 | 1.3 | -0.63 |
| Cerebral Palsy | 0.9 | 0.9 | 0 |
| Chronic Fatigue Syndrome | 3.1 | 3.9 | -0.26 |
| Chronic Kidney Disease | 0.6 | 0.9 | -0.5 |
| Chronic Lyme | 0.4 | -0.4 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 1.9 | 0.9 | 1.11 |
| Chronic Urticaria (Hives) | 0.9 | 0.5 | 0.8 |
| Coagulation / Micro clot triggering bacteria | 0.8 | 1.1 | -0.38 |
| Colorectal Cancer | 2.5 | 2.5 | |
| Constipation | 0.6 | 0.3 | 1 |
| Coronary artery disease | 0.5 | 0.4 | 0.25 |
| COVID-19 | 4.3 | 5.8 | -0.35 |
| Crohn's Disease | 3.2 | 2.8 | 0.14 |
| cystic fibrosis | 0.4 | -0.4 | |
| deep vein thrombosis | 1.1 | -1.1 | |
| Depression | 6.4 | 5 | 0.28 |
| Dermatomyositis | 0.4 | 0.4 | |
| Eczema | 2 | -2 | |
| Endometriosis | 1.4 | 0.7 | 1 |
| Epilepsy | 1.1 | 1.5 | -0.36 |
| Fibromyalgia | 3.1 | 1.9 | 0.63 |
| Functional constipation / chronic idiopathic constipation | 3.1 | 1.9 | 0.63 |
| gallstone disease (gsd) | 1.4 | 0.3 | 3.67 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.8 | 0.4 | 1 |
| Generalized anxiety disorder | 1.1 | -1.1 | |
| giant cell arteritis | 0.5 | -0.5 | |
| Glioblastoma | 0.4 | -0.4 | |
| Gout | 0.4 | -0.4 | |
| Graves' disease | 0.6 | 0.3 | 1 |
| Halitosis | 0.2 | 0.4 | -1 |
| Hashimoto's thyroiditis | 0.4 | 0.2 | 1 |
| Hidradenitis Suppurativa | 0.4 | 0.4 | |
| Histamine Issues,Mast Cell Issue, DAO Insufficiency | 0.7 | 0.7 | |
| hypercholesterolemia (High Cholesterol) | 0.5 | 0.5 | |
| hyperglycemia | 0.6 | -0.6 | |
| hypertension (High Blood Pressure | 1.5 | 1.8 | -0.2 |
| Hypothyroidism | 0.4 | -0.4 | |
| Hypoxia | 0.6 | 0.6 | |
| IgA nephropathy (IgAN) | 1.3 | -1.3 | |
| Inflammatory Bowel Disease | 2.7 | 5 | -0.85 |
| Insomnia | 0.5 | 0.6 | -0.2 |
| Intelligence | 1.3 | 1.3 | |
| Intracranial aneurysms | 1.1 | 1.1 | |
| Irritable Bowel Syndrome | 1.4 | 1.8 | -0.29 |
| Liver Cirrhosis | 2.7 | 2.2 | 0.23 |
| Long COVID | 3.8 | 3.3 | 0.15 |
| Low bone mineral density | 0.9 | -0.9 | |
| Lung Cancer | 0.5 | -0.5 | |
| ME/CFS with IBS | 1.5 | 1 | 0.5 |
| ME/CFS without IBS | 1 | 1.2 | -0.2 |
| Menopause | 0.1 | 0.1 | |
| Metabolic Syndrome | 3.2 | 3.8 | -0.19 |
| Mood Disorders | 8.3 | 5 | 0.66 |
| multiple chemical sensitivity [MCS] | 1 | 1 | |
| Multiple Sclerosis | 2.8 | 5.1 | -0.82 |
| Multiple system atrophy (MSA) | 0.9 | 0.5 | 0.8 |
| Neuropathy (all types) | 0.4 | 0.4 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.9 | 1.3 | -0.44 |
| Obesity | 2.7 | 2.8 | -0.04 |
| obsessive-compulsive disorder | 3.4 | 0.6 | 4.67 |
| Osteoarthritis | 2 | 0.5 | 3 |
| Osteoporosis | 1.2 | 0.2 | 5 |
| pancreatic cancer | 0.4 | 0.4 | |
| Parkinson's Disease | 1.3 | 2.8 | -1.15 |
| Polycystic ovary syndrome | 1.8 | 1.7 | 0.06 |
| Postural orthostatic tachycardia syndrome | 0.5 | 0.4 | 0.25 |
| Premenstrual dysphoric disorder | 0.5 | -0.5 | |
| primary biliary cholangitis | 0.4 | -0.4 | |
| Psoriasis | 1.9 | 2.3 | -0.21 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 2.4 | 1.9 | 0.26 |
| Rosacea | 0.5 | 0.8 | -0.6 |
| Schizophrenia | 3.6 | 1.7 | 1.12 |
| scoliosis | 0.4 | 0.8 | -1 |
| Sjögren syndrome | 0.8 | 1 | -0.25 |
| Sleep Apnea | 0.9 | 0.9 | 0 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.4 | 0.4 | |
| Stress / posttraumatic stress disorder | 1.4 | 0.9 | 0.56 |
| Systemic Lupus Erythematosus | 2 | 0.9 | 1.22 |
| Tic Disorder | 0.7 | 0.7 | |
| Tourette syndrome | 0.2 | -0.2 | |
| Type 1 Diabetes | 1.9 | 1.5 | 0.27 |
| Type 2 Diabetes | 2.9 | 3.8 | -0.31 |
| Ulcerative colitis | 1.4 | 2.5 | -0.79 |
| Unhealthy Ageing | 2.3 | 0.7 | 2.29 |
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