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🍽️ metergoline,(prescription)

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  1. Hyperprolactinemia: Metergoline has been used to lower prolactin levels in conditions such as hyperprolactinemia, which can occur due to various factors including pituitary tumors, certain medications, and hypothalamic dysfunction. By blocking serotonin receptors, metergoline inhibits the release of prolactin from the pituitary gland.

  2. Prolactin-Related Disorders: Elevated prolactin levels can lead to symptoms such as irregular menstrual periods, infertility, galactorrhea (production of breast milk in non-lactating individuals), and sexual dysfunction. Metergoline may help alleviate these symptoms by normalizing prolactin levels.

  3. Migraine: Metergoline has also been investigated for its potential use in the treatment of migraines. Serotonin is believed to play a role in the pathophysiology of migraines, and metergoline's ability to block serotonin receptors may contribute to its effectiveness in preventing migraine attacks.

  4. Psychiatric Disorders: Metergoline's mechanism of action on serotonin receptors suggests potential implications for the treatment of psychiatric disorders such as depression and anxiety. However, its use in these conditions is limited, and other medications with more established efficacy and safety profiles are typically preferred.

  5. Gastrointestinal Disorders: Some research has suggested that metergoline may have effects on gastrointestinal motility and secretion, potentially making it useful in the treatment of conditions such as irritable bowel syndrome (IBS) and gastroparesis. However, further studies are needed to evaluate its efficacy and safety in these indications.

  6. Side Effects: Common side effects associated with metergoline may include gastrointestinal symptoms such as nausea, vomiting, and diarrhea. Additionally, it may cause dizziness, drowsiness, and headaches. Rare but potentially serious side effects may include serotonin syndrome, which is characterized by symptoms such as confusion, agitation, fever, sweating, and rapid heart rate.

  7. Interactions: Metergoline may interact with other medications that affect serotonin levels or serotonin receptors, such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and triptans used for migraine treatment. Combining metergoline with these medications may increase the risk of serotonin syndrome.

  8. Pregnancy and Lactation: The safety of metergoline use during pregnancy and lactation has not been well established. It is generally not recommended for use in pregnant or breastfeeding women unless the potential benefits outweigh the risks and alternative treatments are not suitable.

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βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of metergoline,(prescription) On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Akkermansia muciniphila Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium longum Reduces
species Lacticaseibacillus paracasei Reduces
species Parabacteroides distasonis Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by metergoline,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Akkermansiaceae family Decreases 👪 Source Study
Odoribacter genus Decreases 👪 Source Study
Segatella genus Decreases 👪 Source Study
Agathobacter genus Decreases 👪 Source Study
Blautia genus Decreases 👪 Source Study
Lachnospira genus Decreases 👪 Source Study
Collinsella genus Decreases 👪 Source Study proinflammatory
Dorea genus Decreases 👪 Source Study
Veillonella genus Decreases 👪 Source Study
Bifidobacterium genus Decreases 👪 Source Study
Bacteroides genus Decreases 👪 Source Study
Thomasclavelia genus Decreases 👪 Source Study
Phocaeicola genus Decreases 👪 Source Study
Clostridioides genus Decreases 👪 Source Study
Lacrimispora genus Decreases 👪 Source Study
Roseburia genus Decreases 👪 Source Study
Akkermansia genus Decreases 📓 Source Study
Lacticaseibacillus genus Decreases 👪 Source Study
Clostridium genus Decreases 👪 Source Study Pathogen
Bilophila genus Decreases 👪 Source Study High Level Cause Brain Fog(Cognitive impairment)
Mediterraneibacter genus Decreases 👪 Source Study
Coprococcus genus Decreases 👪 Source Study
Parabacteroides genus Decreases 👪 Source Study BMI, fat percent,blood pressure
Eggerthella genus Decreases 👪 Source Study
Fusobacterium genus Decreases 👪 Source Study Periodontal disease, Lemierre syndrome, skin ulcers
Streptococcus genus Decreases 👪 Source Study
Enterocloster genus Decreases 👪 Source Study
environmental samples no rank Decreases 👶 Source Study
unclassified Akkermansia no rank Decreases 👶 Source Study
Clostridium perfringens A no rank Decreases 👶 Source Study
Clostridium perfringens B no rank Decreases 👶 Source Study
Clostridium perfringens D no rank Decreases 👶 Source Study
Clostridium perfringens E no rank Decreases 👶 Source Study
Odoribacter splanchnicus species Decreases 📓 Source Study
Roseburia hominis species Decreases 📓 Source Study
Segatella copri species Decreases 📓 Source Study Over 70%ile Indicator of mycotoxin present
Agathobacter rectalis species Decreases 📓 Source Study
Bifidobacterium longum species Decreases 📓 Source Study
Bacteroides ovatus species Decreases 📓 Source Study
Blautia obeum species Decreases 📓 Source Study
Lachnospira eligens species Decreases 📓 Source Study
Bacteroides thetaiotaomicron species Decreases 📓 Source Study
Collinsella aerofaciens species Decreases 📓 Source Study
Bacteroides xylanisolvens species Decreases 📓 Source Study
Dorea formicigenerans species Decreases 📓 Source Study
Veillonella parvula species Decreases 📓 Source Study
Bifidobacterium adolescentis species Decreases 📓 Source Study
Thomasclavelia ramosa species Decreases 📓 Source Study
Phocaeicola vulgatus species Decreases 📓 Source Study
Clostridioides difficile species Decreases 📓 Source Study Colitis
Lacrimispora saccharolytica species Decreases 📓 Source Study
Akkermansia muciniphila species Decreases 📓 Source Study High Levels linked to long-lived individuals
Bacteroides caccae species Decreases 📓 Source Study
Bacteroides fragilis species Decreases 📓 Source Study H02076 Bacteroides infection
Lacticaseibacillus paracasei species Decreases 📓 Source Study
Mediterraneibacter gnavus species Decreases 📓 Source Study
Parabacteroides merdae species Decreases 📓 Source Study Infectious bacteria
Clostridium perfringens species Decreases 📓 Source Study Food poisoning, gas gangrene
Bilophila wadsworthia species Decreases 📓 Source Study
Coprococcus comes species Decreases 📓 Source Study
Roseburia intestinalis species Decreases 📓 Source Study
[Ruminococcus] torques species Decreases 📓 Source Study
Eggerthella lenta species Decreases 📓 Source Study
Parabacteroides distasonis species Decreases 📓 Source Study
Akkermansia glycaniphila species Decreases 👶 Source Study
Candidatus Akkermansia intestinavium species Decreases 👶 Source Study
Streptococcus salivarius species Decreases 📓 Source Study Infectious bacteria
Fusobacterium nucleatum species Decreases 📓 Source Study Infectious bacteria
Enterocloster bolteae species Decreases 📓 Source Study
Streptococcus parasanguinis species Decreases 📓 Source Study
Bifidobacterium longum subsp. infantis subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. longum subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. suillum subspecies Decreases 👶 Source Study
Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases 👶 Source Study
Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases 👶 Source Study
Fusobacterium nucleatum subsp. nucleatum subspecies Decreases 👶 Source Study

Impact of metergoline,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.1 0.1
Acne 0.4 -0.4
ADHD 4.4 0.1 43
Age-Related Macular Degeneration and Glaucoma 0.7 0.1 6
Allergic Rhinitis (Hay Fever) 0.8 2.1 -1.63
Allergies 4.8 2.3 1.09
Allergy to milk products 0.5 0.5 0
Alopecia (Hair Loss) 1.5 1.5
Alzheimer's disease 2.6 5.8 -1.23
Amyotrophic lateral sclerosis (ALS) Motor Neuron 3.6 0.5 6.2
Ankylosing spondylitis 3.3 1.1 2
Anorexia Nervosa 0.1 2.2 -21
Antiphospholipid syndrome (APS) 1.1 0.1 10
Asthma 0.6 1.5 -1.5
Atherosclerosis 0.9 1.8 -1
Atrial fibrillation 3.3 1.9 0.74
Autism 7.1 9.7 -0.37
Barrett esophagus cancer 0.5 0 0
Biofilm 0.4 0.4
Bipolar Disorder 0.5 0.9 -0.8
Brain Trauma 0.9 0.6 0.5
Cancer (General) 0.5 2.9 -4.8
Carcinoma 2.9 2.7 0.07
Celiac Disease 2 4.5 -1.25
Cerebral Palsy 1.3 1.1 0.18
Chronic Fatigue Syndrome 3.4 7 -1.06
Chronic Kidney Disease 0.9 2.3 -1.56
Chronic Lyme 0.6 -0.6
Chronic Obstructive Pulmonary Disease (COPD) 0.6 0.8 -0.33
Chronic Urticaria (Hives) 0.6 1.9 -2.17
Coagulation / Micro clot triggering bacteria 0.1 0.8 -7
Colorectal Cancer 2.2 1.3 0.69
Constipation 1.5 0.8 0.88
Coronary artery disease 1.2 1 0.2
COVID-19 10.3 14.2 -0.38
Crohn's Disease 4.8 6.2 -0.29
cystic fibrosis 1.1 -1.1
deep vein thrombosis 0.3 -0.3
Depression 6.3 7.6 -0.21
Dermatomyositis 0 0.4 0
Eczema 0.7 1 -0.43
Endometriosis 1.9 1.4 0.36
Eosinophilic Esophagitis 0 0.4 0
Epilepsy 2.4 2.4 0
Fibromyalgia 2.3 2 0.15
Functional constipation / chronic idiopathic constipation 4.5 3.2 0.41
gallstone disease (gsd) 1.5 0.7 1.14
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 1.5 1 0.5
Generalized anxiety disorder 0.8 1.9 -1.37
giant cell arteritis 0.1 -0.1
Glioblastoma 0 0
Gout 0.1 -0.1
Graves' disease 1.3 1.7 -0.31
Halitosis 0.8 0 0
Hashimoto's thyroiditis 2.4 0.9 1.67
Hidradenitis Suppurativa 0.2 0.4 -1
High Histamine/low DAO 0.6 0.4 0.5
hypercholesterolemia (High Cholesterol) 0.6 0.5 0.2
hyperglycemia 0.1 2.1 -20
Hyperlipidemia (High Blood Fats) 1.1 0.5 1.2
hypersomnia 0.6 -0.6
hypertension (High Blood Pressure 1.6 6.5 -3.06
Hypothyroidism 1 -1
Hypoxia 0.7 0.7
IgA nephropathy (IgAN) 4.5 -4.5
Inflammatory Bowel Disease 2.8 7.9 -1.82
Insomnia 0.9 1.1 -0.22
Intelligence 0.2 1 -4
Intracranial aneurysms 0.9 0.5 0.8
Irritable Bowel Syndrome 3.5 4.2 -0.2
Liver Cirrhosis 3.6 2.5 0.44
Long COVID 7.3 9.5 -0.3
Low bone mineral density 0.8 -0.8
Lung Cancer 0.4 1.5 -2.75
Mast Cell Issues / mastitis 0 0.5 0
ME/CFS with IBS 0.2 2.8 -13
ME/CFS without IBS 0.6 2.2 -2.67
Menopause 2.6 2.6
Metabolic Syndrome 5.7 7.8 -0.37
Mood Disorders 8.5 7.6 0.12
multiple chemical sensitivity [MCS] 0.8 0.5 0.6
Multiple Sclerosis 3.6 4.4 -0.22
Multiple system atrophy (MSA) 1.8 0.9 1
neuropathic pain 2.4 -2.4
Neuropathy (all types) 0.8 0.8
neuropsychiatric disorders (PANDAS, PANS) 0.5 0.5
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 2.5 6.4 -1.56
NonCeliac Gluten Sensitivity 1.9 0.8 1.37
Obesity 7.9 4 0.98
obsessive-compulsive disorder 4.9 4.7 0.04
Osteoarthritis 1.5 1.5
Osteoporosis 1 1.4 -0.4
pancreatic cancer 0.5 0.5
Parkinson's Disease 5 5.6 -0.12
Polycystic ovary syndrome 1.7 1.6 0.06
Postural orthostatic tachycardia syndrome 0.1 0.5 -4
Premenstrual dysphoric disorder 1.3 0.1 12
primary biliary cholangitis 0.4 0.5 -0.25
Psoriasis 3.9 2.4 0.63
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 5.7 3.5 0.63
Rosacea 0.5 0.4 0.25
Schizophrenia 5.9 1.4 3.21
scoliosis 0.1 1 -9
Sjögren syndrome 3.4 3 0.13
Sleep Apnea 1 1.3 -0.3
Slow gastric motility / Gastroparesis 0.8 0.4 1
Small Intestinal Bacterial Overgrowth (SIBO) 0.1 1 -9
Stress / posttraumatic stress disorder 2 2.3 -0.15
Systemic Lupus Erythematosus 2.8 2.1 0.33
Tic Disorder 1.2 2.3 -0.92
Tourette syndrome 0.3 0.4 -0.33
Type 1 Diabetes 3.5 2.2 0.59
Type 2 Diabetes 6.3 5.4 0.17
Ulcerative colitis 2 5.3 -1.65
Unhealthy Ageing 3.3 2.5 0.32
Vitiligo 1.3 1.1 0.18

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