🍽️ vidarabine,(prescription)

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  1. Antiviral Activity: Vidarabine is a nucleoside analog antiviral medication that inhibits the replication of herpes simplex virus by interfering with viral DNA synthesis. It is effective against both herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2).

  2. Treatment of Herpes Simplex Keratitis: Vidarabine is commonly used as a topical ophthalmic ointment or solution for the treatment of herpes simplex keratitis, a viral infection of the cornea that can cause eye pain, redness, tearing, and blurred vision. By inhibiting viral replication, vidarabine helps reduce the severity and duration of symptoms associated with herpes simplex keratitis.

  3. Herpes Simplex Virus Infections: In addition to herpes simplex keratitis, vidarabine may be used in the treatment of other localized herpes simplex virus infections, such as herpes labialis (cold sores) and herpes genitalis (genital herpes). It is applied directly to the affected area as a topical medication to suppress viral replication and promote healing.

  4. Mechanism of Action: Vidarabine exerts its antiviral effects by being phosphorylated intracellularly to its active form, vidarabine triphosphate. Vidarabine triphosphate competes with deoxyadenosine triphosphate (dATP) for incorporation into viral DNA by the viral DNA polymerase. Once incorporated, vidarabine triphosphate terminates viral DNA chain elongation, leading to inhibition of viral replication.

  5. Topical Administration: Vidarabine is typically administered as a topical ophthalmic ointment or solution for the treatment of herpes simplex keratitis. It is applied directly to the affected eye(s) several times daily as directed by a healthcare provider. The frequency and duration of treatment may vary depending on the severity of the infection and the patient's response to therapy.

  6. Adverse Effects: Common side effects associated with vidarabine therapy may include local irritation or burning sensation at the application site, transient blurred vision, and increased lacrimation (tearing). These side effects are usually mild and resolve spontaneously with continued use.

  7. Patient Monitoring: Patients receiving vidarabine therapy should be monitored regularly by a healthcare provider to assess treatment response, monitor for adverse effects, and ensure proper management of the underlying herpes simplex virus infection. Any worsening of symptoms or development of new ocular symptoms should be reported promptly to a healthcare provider.

  8. Contraindications: Vidarabine is contraindicated in patients with known hypersensitivity to the medication or any of its components. It should not be used in patients with active fungal, bacterial, or viral infections of the eye other than herpes simplex keratitis.

  9. Pregnancy and Lactation: The safety of vidarabine use during pregnancy or breastfeeding has not been well established. Healthcare providers should weigh the potential benefits and risks of treatment when considering the use of vidarabine in pregnant or lactating women.

  10. Drug Interactions: There are no significant drug interactions reported with vidarabine. However, patients should inform their healthcare provider about all medications, including prescription, over-the-counter, and herbal products, before starting vidarabine therapy to prevent potential drug interactions.

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βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of vidarabine,(prescription) On Probiotics

Rank Probiotic Impact
species Akkermansia muciniphila Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium longum Reduces
species Escherichia coli Reduces
species Lacticaseibacillus paracasei Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by vidarabine,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Bilophila genus Decreases 👪 Source Study High Level Cause Brain Fog(Cognitive impairment)
Blautia genus Decreases 👪 Source Study
Collinsella genus Decreases 👪 Source Study proinflammatory
Clostridioides genus Decreases 👪 Source Study
Veillonella genus Decreases 👪 Source Study
Clostridium genus Decreases 👪 Source Study Pathogen
Dorea genus Decreases 👪 Source Study
Escherichia genus Decreases 👪 Source Study
Fusobacterium genus Decreases 👪 Source Study Periodontal disease, Lemierre syndrome, skin ulcers
Streptococcus genus Decreases 👪 Source Study
Bifidobacterium genus Decreases 👪 Source Study
Roseburia genus Decreases 👪 Source Study
Agathobacter genus Decreases 👪 Source Study
Odoribacter genus Decreases 👪 Source Study
Mediterraneibacter genus Decreases 👪 Source Study
Parabacteroides genus Decreases 👪 Source Study BMI, fat percent,blood pressure
Bacteroides genus Decreases 👪 Source Study
Phocaeicola genus Decreases 👪 Source Study
Lacrimispora genus Decreases 👪 Source Study
Lachnospira genus Decreases 👪 Source Study
Enterocloster genus Decreases 👪 Source Study
Lacticaseibacillus genus Decreases 👪 Source Study
Akkermansia genus Decreases 👪 Source Study
Escherichia coli O80:H26 no rank Decreases 👶 Source Study
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
unclassified Negativicoccus no rank Decreases ⚗️ Source Study
Eggerthellales order Decreases ⚗️ Source Study
Escherichia coli O145 serogroup Decreases 👶 Source Study
Escherichia coli O157 serogroup Decreases 👶 Source Study
Escherichia coli O26 serogroup Decreases 👶 Source Study
Escherichia coli O43 serogroup Decreases 👶 Source Study
Escherichia coli O1:H42 serotype Decreases 👶 Source Study
Escherichia coli O104:H4 serotype Decreases 👶 Source Study
Escherichia coli O121:H19 serotype Decreases 👶 Source Study
Escherichia coli O127:H6 serotype Decreases 👶 Source Study
Escherichia coli O139:H28 serotype Decreases 👶 Source Study
Escherichia coli O157:H7 serotype Decreases 👶 Source Study bloody diarrhea
Escherichia coli O44:H18 serotype Decreases 👶 Source Study
Escherichia coli O55:H7 serotype Decreases 👶 Source Study
Escherichia coli O6:H16 serotype Decreases 👶 Source Study
Escherichia coli O7:K1 serotype Decreases 👶 Source Study
Bilophila wadsworthia species Decreases 📓 Source Study
Blautia obeum species Decreases 📓 Source Study
Collinsella aerofaciens species Decreases 📓 Source Study
Clostridioides difficile species Decreases 📓 Source Study Colitis
Bifidobacterium adolescentis species Decreases 📓 Source Study
Roseburia hominis species Decreases 📓 Source Study
Veillonella parvula species Decreases 📓 Source Study
Streptococcus parasanguinis species Decreases 📓 Source Study
Clostridium perfringens species Decreases 📓 Source Study Food poisoning, gas gangrene
Dorea formicigenerans species Decreases 📓 Source Study
Bacteroides ovatus species Decreases 📓 Source Study
Bacteroides caccae species Decreases 📓 Source Study
Escherichia coli species Decreases 📓 Source Study Diarrheal disease in children and travelers, Foodborne diarrhea outbreaks, hemorrhagic colitis, hemolytic-uremic syndrome
Fusobacterium nucleatum species Decreases 📓 Source Study Infectious bacteria
[Ruminococcus] gnavus species Decreases 📓 Source Study
Agathobacter rectalis species Decreases 📓 Source Study
Parabacteroides merdae species Decreases 📓 Source Study Infectious bacteria
Odoribacter splanchnicus species Decreases 📓 Source Study
Streptococcus salivarius species Decreases 📓 Source Study Infectious bacteria
Bacteroides uniformis species Decreases 📓 Source Study Infectious bacteria
Bifidobacterium longum species Decreases 📓 Source Study
Parabacteroides distasonis species Decreases 📓 Source Study
Bacteroides xylanisolvens species Decreases 📓 Source Study
[Ruminococcus] torques species Decreases 📓 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Roseburia intestinalis species Decreases 📓 Source Study
Phocaeicola vulgatus species Decreases 📓 Source Study
Bacteroides fragilis species Decreases 📓 Source Study H02076 Bacteroides infection
Negativicoccus sp. S5-A15 species Decreases ⚗️ Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Lacrimispora saccharolytica species Decreases 📓 Source Study
Lachnospira eligens species Decreases 📓 Source Study
Enterocloster bolteae species Decreases 📓 Source Study
Bacteroides thetaiotaomicron species Decreases 📓 Source Study
Lacticaseibacillus paracasei species Decreases 📓 Source Study
Akkermansia muciniphila species Decreases 📓 Source Study
Coriobacterineae suborder Decreases ⚗️ Source Study
Fusobacterium nucleatum subsp. nucleatum subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. infantis subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. longum subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. suillum subspecies Decreases 👶 Source Study
Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases 👶 Source Study
Chlamydiae/Verrucomicrobia group superphylum Decreases ⚗️ Source Study

Impact of vidarabine,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.5 0.5
Acne 0.3 -0.3
ADHD 3.7 3.7
Age-Related Macular Degeneration and Glaucoma 0.7 0.2 2.5
Allergic Rhinitis (Hay Fever) 1.7 1.5 0.13
Allergies 4.8 1.3 2.69
Allergy to milk products 1.2 0.8 0.5
Alopecia (Hair Loss) 1.6 1.6
Alzheimer's disease 3.5 5.2 -0.49
Amyotrophic lateral sclerosis (ALS) Motor Neuron 1.6 0.7 1.29
Ankylosing spondylitis 3.7 1.1 2.36
Anorexia Nervosa 0.2 1.6 -7
Antiphospholipid syndrome (APS) 1.2 0.5 1.4
Asthma 0.7 0.5 0.4
Atherosclerosis 1.1 1.3 -0.18
Atrial fibrillation 2.6 1.5 0.73
Autism 6.6 6 0.1
Barrett esophagus cancer 0.8 0.3 1.67
benign prostatic hyperplasia 0.3 0.3
Bipolar Disorder 1.2 0.7 0.71
Brain Trauma 0.8 0.4 1
Cancer (General) 0.2 2.8 -13
Carcinoma 3.4 2.3 0.48
Celiac Disease 2 3.1 -0.55
Cerebral Palsy 1.5 0.9 0.67
Chronic Fatigue Syndrome 4.8 6.3 -0.31
Chronic Kidney Disease 1.5 1.3 0.15
Chronic Lyme 0.4 -0.4
Chronic Obstructive Pulmonary Disease (COPD) 2.3 0.3 6.67
Chronic Urticaria (Hives) 2.1 0.2 9.5
Coagulation / Micro clot triggering bacteria 1.5 1.1 0.36
Colorectal Cancer 3.7 1 2.7
Constipation 0.7 0.8 -0.14
Coronary artery disease 1.3 0.9 0.44
COVID-19 9.3 8.9 0.04
Crohn's Disease 6.9 3.7 0.86
cystic fibrosis 1 0.7 0.43
deep vein thrombosis 1 0.6 0.67
Depression 7 6 0.17
Dermatomyositis 0.3 0.3 0
Eczema 1.3 1.6 -0.23
Endometriosis 2.8 0.7 3
Eosinophilic Esophagitis 0.3 0.4 -0.33
Epilepsy 2.6 1.7 0.53
Fibromyalgia 2.2 1.2 0.83
Functional constipation / chronic idiopathic constipation 3.6 2.2 0.64
gallstone disease (gsd) 2.2 0.9 1.44
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 1.1 1.3 -0.18
Generalized anxiety disorder 2.4 1.2 1
giant cell arteritis 0.4 -0.4
Glioblastoma 0.3 -0.3
Graves' disease 1.1 1.6 -0.45
Halitosis 0.9 0.3 2
Hashimoto's thyroiditis 1.9 1 0.9
Hidradenitis Suppurativa 1.1 0.4 1.75
Histamine Issues 2.7 0.9 2
hypercholesterolemia (High Cholesterol) 0.6 0 0
hyperglycemia 0.3 1.2 -3
Hyperlipidemia (High Blood Fats) 0.8 0.5 0.6
hypersomnia 1 -1
hypertension (High Blood Pressure 1.8 4.2 -1.33
Hypothyroidism 0.8 -0.8
Hypoxia 0.4 0.4
IgA nephropathy (IgAN) 2.4 -2.4
Inflammatory Bowel Disease 3.4 4.4 -0.29
Insomnia 1 0.5 1
Intelligence 0.7 0.7
Intracranial aneurysms 0.9 0.5 0.8
Irritable Bowel Syndrome 3.3 2.6 0.27
Liver Cirrhosis 4.4 2.8 0.57
Long COVID 5.1 6.9 -0.35
Low bone mineral density 0.3 -0.3
Lung Cancer 1 0.9 0.11
Mast Cell Issues / mastitis 0.6 0.3 1
ME/CFS with IBS 0.8 2.2 -1.75
ME/CFS without IBS 1.4 1.9 -0.36
Menopause 1.9 1.9
Metabolic Syndrome 7.4 6.4 0.16
Mood Disorders 9.7 6 0.62
multiple chemical sensitivity [MCS] 1.1 0.5 1.2
Multiple Sclerosis 4.1 3.2 0.28
Multiple system atrophy (MSA) 1.8 0.8 1.25
neuropathic pain 1.2 -1.2
Neuropathy (all types) 0.8 0.3 1.67
neuropsychiatric disorders (PANDAS, PANS) 0.9 0.9
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 2.4 4 -0.67
NonCeliac Gluten Sensitivity 0.3 -0.3
Obesity 8.4 3 1.8
obsessive-compulsive disorder 5.4 2.7 1
Osteoarthritis 1.8 1.8
Osteoporosis 1.3 0.7 0.86
pancreatic cancer 0.5 0.5
Parkinson's Disease 2.5 2.8 -0.12
Polycystic ovary syndrome 1.8 1.2 0.5
Postural orthostatic tachycardia syndrome 0.4 0.3 0.33
Premenstrual dysphoric disorder 1.3 0.2 5.5
primary biliary cholangitis 0.4 0.8 -1
Psoriasis 4.5 1 3.5
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 5.7 3.2 0.78
Rosacea 0.5 0.7 -0.4
Schizophrenia 5.5 1.5 2.67
scoliosis 0.6 -0.6
Sjögren syndrome 2.9 3 -0.03
Sleep Apnea 1.1 0.9 0.22
Small Intestinal Bacterial Overgrowth (SIBO) 1.3 0.3 3.33
Stress / posttraumatic stress disorder 2.7 1.2 1.25
Systemic Lupus Erythematosus 3.7 1.3 1.85
Tic Disorder 0.4 1.2 -2
Tourette syndrome 0 0.2 0
Type 1 Diabetes 3 2.1 0.43
Type 2 Diabetes 7.2 4.3 0.67
Ulcerative colitis 3.1 3.3 -0.06
Unhealthy Ageing 4.5 1.3 2.46

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