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🍽️ flunarizine dihydrochloride,(prescription)

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  1. Migraine Prophylaxis: Flunarizine is effective in reducing the frequency, severity, and duration of migraine attacks. It is commonly prescribed for individuals with recurrent migraines to prevent the onset of headaches and associated symptoms such as nausea, vomiting, and sensitivity to light and sound.

  2. Vestibular Disorders: Flunarizine is also used to manage various vestibular disorders, including vertigo and Meniere's disease. It helps alleviate symptoms such as dizziness, spinning sensation (vertigo), imbalance, and nausea by stabilizing the inner ear and reducing abnormal sensory input to the brain.

  3. Calcium Channel Blocker: Flunarizine acts as a calcium channel blocker, primarily targeting calcium channels in neuronal membranes. By inhibiting calcium influx into cells, particularly in cerebral and vascular tissues, flunarizine exerts its therapeutic effects, including vasodilation and suppression of neuronal excitability.

  4. Preventive Therapy: Flunarizine is typically used as a preventive therapy rather than an acute treatment for migraine attacks. It is taken on a regular basis, often as a long-term prophylactic measure, to reduce the frequency and severity of migraine episodes over time.

  5. Dosage and Administration: Flunarizine is available in oral tablet form and is usually taken once daily. The dosage may vary depending on the individual's age, medical condition, and response to treatment. It is important to follow the prescribed dosage and instructions provided by a healthcare professional.

  6. Side Effects: Common side effects of flunarizine may include drowsiness, fatigue, weight gain, increased appetite, and gastrointestinal disturbances such as nausea and abdominal discomfort. These side effects are usually mild and transient but may necessitate dose adjustment or discontinuation of the medication in some cases.

  7. Central Nervous System Effects: Flunarizine may cause central nervous system (CNS) side effects, including sedation, depression, and extrapyramidal symptoms such as tremors and dystonia. Patients should be advised to exercise caution when operating machinery or engaging in activities requiring mental alertness until they know how the medication affects them.

  8. Cardiovascular Effects: Flunarizine may rarely cause cardiovascular side effects, including changes in heart rate, blood pressure, and electrocardiogram (ECG) parameters. It should be used with caution in individuals with preexisting cardiovascular conditions, and cardiac function should be monitored periodically during treatment.

  9. Contraindications: Flunarizine is contraindicated in individuals with a history of hypersensitivity to the drug or its components. It should be avoided in patients with severe depression, Parkinson's disease, or a history of movement disorders such as tardive dyskinesia.

  10. Drug Interactions: Flunarizine may interact with other medications, including central nervous system depressants, antihypertensive drugs, and selective serotonin reuptake inhibitors (SSRIs), leading to additive CNS effects or changes in blood pressure. It is important to inform healthcare providers about all medications being taken to avoid potential interactions.

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βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of flunarizine dihydrochloride,(prescription) On Probiotics

Rank Probiotic Impact
species Bacteroides uniformis Reduces
species Lacticaseibacillus paracasei Reduces
species Parabacteroides distasonis Reduces

Bacteria Impacted by flunarizine dihydrochloride,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Lachnospira genus Decreases 👪 Source Study
Agathobacter genus Decreases 👪 Source Study
Phocaeicola genus Decreases 👪 Source Study
Mediterraneibacter genus Decreases 👪 Source Study
Blautia genus Decreases 👪 Source Study
Lacticaseibacillus genus Decreases 👪 Source Study
Bacteroides genus Decreases 👪 Source Study
Eggerthella genus Decreases 👪 Source Study
Clostridioides genus Decreases 👪 Source Study
Lacrimispora genus Decreases 👪 Source Study
Segatella genus Decreases 👪 Source Study
Roseburia genus Decreases 👪 Source Study
Parabacteroides genus Decreases 👪 Source Study BMI, fat percent,blood pressure
Collinsella genus Decreases 👪 Source Study proinflammatory
Dorea genus Decreases 👪 Source Study
Coprococcus genus Decreases 👪 Source Study
Thomasclavelia genus Decreases 👪 Source Study
Streptococcus genus Decreases 👪 Source Study
Clostridium genus Decreases 👪 Source Study Pathogen
Clostridium perfringens A no rank Decreases 👶 Source Study
Clostridium perfringens B no rank Decreases 👶 Source Study
Clostridium perfringens D no rank Decreases 👶 Source Study
Clostridium perfringens E no rank Decreases 👶 Source Study
Roseburia intestinalis species Decreases 📓 Source Study
Lachnospira eligens species Decreases 📓 Source Study
Bacteroides uniformis species Decreases 📓 Source Study Infectious bacteria
Agathobacter rectalis species Decreases 📓 Source Study
Phocaeicola vulgatus species Decreases 📓 Source Study
[Ruminococcus] torques species Decreases 📓 Source Study
Mediterraneibacter gnavus species Decreases 📓 Source Study
Blautia obeum species Decreases 📓 Source Study
Lacticaseibacillus paracasei species Decreases 📓 Source Study
Eggerthella lenta species Decreases 📓 Source Study
Bacteroides fragilis species Decreases 📓 Source Study H02076 Bacteroides infection
Clostridioides difficile species Decreases 📓 Source Study Colitis
Lacrimispora saccharolytica species Decreases 📓 Source Study
Parabacteroides merdae species Decreases 📓 Source Study Infectious bacteria
Segatella copri species Decreases 📓 Source Study Over 70%ile Indicator of mycotoxin present
Bacteroides thetaiotaomicron species Decreases 📓 Source Study
Parabacteroides distasonis species Decreases 📓 Source Study
Collinsella aerofaciens species Decreases 📓 Source Study
Dorea formicigenerans species Decreases 📓 Source Study
Coprococcus comes species Decreases 📓 Source Study
Thomasclavelia ramosa species Decreases 📓 Source Study
Streptococcus parasanguinis species Decreases 📓 Source Study
Streptococcus salivarius species Decreases 📓 Source Study Infectious bacteria
Roseburia hominis species Decreases 📓 Source Study
Clostridium perfringens species Decreases 📓 Source Study Food poisoning, gas gangrene
Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases 👶 Source Study
Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases 👶 Source Study

Impact of flunarizine dihydrochloride,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
ADHD 2 0.5 3
Age-Related Macular Degeneration and Glaucoma 0.5 0.3 0.67
Allergic Rhinitis (Hay Fever) 1.6 1.6
Allergies 3.5 0.6 4.83
Allergy to milk products 0.4 0.3 0.33
Alopecia (Hair Loss) 1.4 1.4
Alzheimer's disease 2 5 -1.5
Amyotrophic lateral sclerosis (ALS) Motor Neuron 2.1 2.1
Ankylosing spondylitis 2.1 1.8 0.17
Anorexia Nervosa 0.3 2.1 -6
Antiphospholipid syndrome (APS) 1.6 1.6
Asthma 0.7 0.6 0.17
Atherosclerosis 0.2 1.3 -5.5
Atrial fibrillation 2.6 1.2 1.17
Autism 6.6 6.6 0
Barrett esophagus cancer 0.1 -0.1
Biofilm 1.2 1.2
Bipolar Disorder 0.6 0.8 -0.33
Brain Trauma 0.2 0.6 -2
Cancer (General) 0.9 -0.9
Carcinoma 2 1.5 0.33
Celiac Disease 1.5 1.8 -0.2
Cerebral Palsy 0.2 1.1 -4.5
Chronic Fatigue Syndrome 4.4 5.7 -0.3
Chronic Kidney Disease 2.8 2.1 0.33
Chronic Lyme 0.6 -0.6
Chronic Obstructive Pulmonary Disease (COPD) 0.7 1 -0.43
Chronic Urticaria (Hives) 0.2 1.2 -5
Coagulation / Micro clot triggering bacteria 0.4 0.9 -1.25
Colorectal Cancer 1.9 0.7 1.71
Constipation 1.8 0.7 1.57
Coronary artery disease 1.6 0.6 1.67
COVID-19 6.6 10.6 -0.61
Crohn's Disease 5 5.1 -0.02
cystic fibrosis 0.6 -0.6
deep vein thrombosis 0.4 -0.4
Depression 6.3 5.7 0.11
Dermatomyositis 0.1 0.1
Eczema 0.9 1.2 -0.33
Endometriosis 1.6 0.5 2.2
Epilepsy 1.9 1.7 0.12
Fibromyalgia 2.3 2.3 0
Functional constipation / chronic idiopathic constipation 3.8 3 0.27
gallstone disease (gsd) 1 0.3 2.33
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 1.6 1 0.6
Generalized anxiety disorder 1.4 0.6 1.33
giant cell arteritis 0 0
Glioblastoma 0.1 -0.1
Gout 0.2 -0.2
Graves' disease 0.9 1.2 -0.33
Halitosis 0.4 0.1 3
Hashimoto's thyroiditis 2.2 0.4 4.5
Hidradenitis Suppurativa 0.1 0.1
High Histamine/low DAO 0.4 0.4
hypercholesterolemia (High Cholesterol) 0 0
hyperglycemia 1.1 -1.1
Hyperlipidemia (High Blood Fats) 0.2 0.2 0
hypersomnia 0.4 -0.4
hypertension (High Blood Pressure 1 2.7 -1.7
Hypothyroidism 1 -1
Hypoxia 0.6 0.6
IgA nephropathy (IgAN) 4 -4
Inflammatory Bowel Disease 3.4 6.4 -0.88
Insomnia 1 1.1 -0.1
Intelligence 1.2 0.6 1
Intracranial aneurysms 1.1 0.2 4.5
Irritable Bowel Syndrome 1.2 3.3 -1.75
Liver Cirrhosis 2 1.2 0.67
Long COVID 5.9 5.8 0.02
Low bone mineral density 1 -1
Lung Cancer 0.7 -0.7
Mast Cell Issues / mastitis 0.1 0.2 -1
ME/CFS with IBS 0.2 2.1 -9.5
ME/CFS without IBS 2.2 1.5 0.47
Metabolic Syndrome 4.6 4.7 -0.02
Mood Disorders 6.8 6 0.13
multiple chemical sensitivity [MCS] 0.4 0.4 0
Multiple Sclerosis 2.7 4.8 -0.78
Multiple system atrophy (MSA) 0.4 0.4 0
neuropathic pain 1 -1
Neuropathy (all types) 0.6 0.6
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 1.6 3.3 -1.06
NonCeliac Gluten Sensitivity 1 0.4 1.5
Obesity 5 2.8 0.79
obsessive-compulsive disorder 5.5 4.1 0.34
Osteoarthritis 1.8 1.8
Osteoporosis 0.7 0.8 -0.14
pancreatic cancer 0.1 0.1
Parkinson's Disease 3.9 5.3 -0.36
Polycystic ovary syndrome 2.1 0.3 6
Postural orthostatic tachycardia syndrome 0 0.2 0
Premenstrual dysphoric disorder 0.7 0.3 1.33
primary biliary cholangitis 0.2 1.2 -5
Psoriasis 2.2 2.1 0.05
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 4.9 2 1.45
Rosacea 0.9 0.3 2
Schizophrenia 3 0.9 2.33
scoliosis 0.2 1 -4
Sjögren syndrome 1.4 2.8 -1
Sleep Apnea 0.6 1.6 -1.67
Slow gastric motility / Gastroparesis 0.4 0.4
Small Intestinal Bacterial Overgrowth (SIBO) 0.1 0.1
Stress / posttraumatic stress disorder 1.2 1.7 -0.42
Systemic Lupus Erythematosus 3.4 1.2 1.83
Tic Disorder 1 1 0
Tourette syndrome 0.4 -0.4
Type 1 Diabetes 2.6 1.9 0.37
Type 2 Diabetes 5.5 5.1 0.08
Ulcerative colitis 1.6 3.6 -1.25
Unhealthy Ageing 5.2 1.4 2.71
Vitiligo 1.3 0.7 0.86

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