🍽️ 2-aminobenzenesulfonamide (antibiotic)

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  1. Antibacterial Activity: Sulfanilamide works by inhibiting the growth of bacteria by interfering with the synthesis of folic acid, which is essential for bacterial DNA synthesis and replication. It is effective against a range of bacterial infections, including urinary tract infections, respiratory tract infections, and skin infections caused by susceptible bacteria.

  2. Side Effects: Like other antibiotics, sulfanilamide can cause side effects. Common side effects may include nausea, vomiting, diarrhea, stomach pain, headache, dizziness, and skin rash. Some individuals may also experience allergic reactions, including severe skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis, although these are rare.

  3. Hypersensitivity Reactions: Sulfanilamide can cause hypersensitivity reactions in some individuals, particularly those with a history of allergies to sulfa drugs or related medications. Hypersensitivity reactions may include rash, itching, swelling, difficulty breathing, and anaphylaxis. Patients with a known allergy to sulfanilamide or sulfa drugs should avoid sulfanilamide-containing medications.

  4. Blood Disorders: Rarely, sulfanilamide can cause blood disorders such as agranulocytosis (severe depletion of white blood cells), hemolytic anemia (destruction of red blood cells), and thrombocytopenia (low platelet count). Patients should be monitored for signs of blood disorders while taking sulfanilamide, and treatment should be discontinued if these complications occur.

  5. Renal Impairment: Sulfanilamide is primarily excreted by the kidneys, so patients with renal impairment may require dosage adjustments or closer monitoring to prevent drug accumulation and potential toxicity. Kidney function should be assessed before starting treatment with sulfanilamide, and dosage adjustments may be necessary in patients with impaired renal function.

  6. Drug Interactions: Sulfanilamide may interact with other medications, potentially increasing the risk of side effects or reducing the effectiveness of other drugs. It's important for patients to inform their healthcare providers about all medications, supplements, and herbal products they are taking before starting treatment with sulfanilamide.

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βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of 2-aminobenzenesulfonamide (antibiotic) On Probiotics

Rank Probiotic Impact
species Akkermansia muciniphila Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium longum Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by 2-aminobenzenesulfonamide (antibiotic)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Akkermansiaceae family Decreases 👪 Source Study
Enterocloster genus Decreases 👪 Source Study
Blautia genus Decreases 👪 Source Study
Bifidobacterium genus Decreases 👪 Source Study
Thomasclavelia genus Decreases 👪 Source Study
Veillonella genus Decreases 👪 Source Study
Eggerthella genus Decreases 👪 Source Study
Ruminococcus genus Decreases 👪 Source Study
Collinsella genus Decreases 👪 Source Study proinflammatory
Odoribacter genus Decreases 👪 Source Study
Lacrimispora genus Decreases 👪 Source Study
Agathobacter genus Decreases 👪 Source Study
Parabacteroides genus Decreases 👪 Source Study BMI, fat percent,blood pressure
Bacteroides genus Decreases 👪 Source Study
Dorea genus Decreases 👪 Source Study
Roseburia genus Decreases 👪 Source Study
Mediterraneibacter genus Decreases 👪 Source Study
Streptococcus genus Decreases 👪 Source Study
Clostridioides genus Decreases 👪 Source Study
Akkermansia genus Decreases 📓 Source Study
Lachnospira genus Decreases 👪 Source Study
Phocaeicola genus Decreases 👪 Source Study
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
unclassified Negativicoccus no rank Decreases ⚗️ Source Study
environmental samples no rank Decreases 👶 Source Study
unclassified Akkermansia no rank Decreases 👶 Source Study
Eggerthellales order Decreases ⚗️ Source Study
Enterocloster bolteae species Decreases 📓 Source Study
Blautia obeum species Decreases 📓 Source Study
Bifidobacterium adolescentis species Decreases 📓 Source Study
Bifidobacterium longum species Decreases 📓 Source Study
Thomasclavelia ramosa species Decreases 📓 Source Study
Veillonella parvula species Decreases 📓 Source Study
Eggerthella lenta species Decreases 📓 Source Study
Ruminococcus bromii species Decreases 📓 Source Study
Bacteroides xylanisolvens species Decreases 📓 Source Study
Collinsella aerofaciens species Decreases 📓 Source Study
Odoribacter splanchnicus species Decreases 📓 Source Study
Lacrimispora saccharolytica species Decreases 📓 Source Study
Agathobacter rectalis species Decreases 📓 Source Study
Parabacteroides distasonis species Decreases 📓 Source Study
[Ruminococcus] torques species Decreases 📓 Source Study
Bacteroides ovatus species Decreases 📓 Source Study
Bacteroides caccae species Decreases 📓 Source Study
Roseburia hominis species Decreases 📓 Source Study
Dorea formicigenerans species Decreases 📓 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Bacteroides thetaiotaomicron species Decreases 📓 Source Study
Streptococcus parasanguinis species Decreases 📓 Source Study
Negativicoccus sp. S5-A15 species Decreases ⚗️ Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Roseburia intestinalis species Decreases 📓 Source Study
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Clostridioides difficile species Decreases 📓 Source Study Colitis
[Ruminococcus] gnavus species Decreases 📓 Source Study
Akkermansia muciniphila species Decreases 📓 Source Study
Lachnospira eligens species Decreases 📓 Source Study
Phocaeicola vulgatus species Decreases 📓 Source Study
Akkermansia glycaniphila species Decreases 👶 Source Study
Coriobacterineae suborder Decreases ⚗️ Source Study
Bifidobacterium longum subsp. infantis subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. longum subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. suillum subspecies Decreases 👶 Source Study
Chlamydiae/Verrucomicrobia group superphylum Decreases ⚗️ Source Study

Impact of 2-aminobenzenesulfonamide (antibiotic) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Acne 0.3 -0.3
ADHD 2.6 0.2 12
Age-Related Macular Degeneration and Glaucoma 0.2 0.2 0
Allergic Rhinitis (Hay Fever) 0.4 1.5 -2.75
Allergies 2.4 1.1 1.18
Allergy to milk products 0.3 0.5 -0.67
Alopecia (Hair Loss) 1 1
Alzheimer's disease 1.4 2.5 -0.79
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.7 0.2 2.5
Ankylosing spondylitis 1.7 0.4 3.25
Anorexia Nervosa 0.2 1 -4
Antiphospholipid syndrome (APS) 0.4 0.4
Asthma 0.8 0.3 1.67
Atherosclerosis 0.7 0.6 0.17
Atrial fibrillation 1.9 0.6 2.17
Autism 3.6 3.5 0.03
Barrett esophagus cancer 0.3 0.1 2
Biofilm 0.2 0.2
Bipolar Disorder 0.5 0.8 -0.6
Brain Trauma 0.5 0.2 1.5
Cancer (General) 0.2 1.7 -7.5
Carcinoma 2 1.7 0.18
Celiac Disease 0.7 2.5 -2.57
Cerebral Palsy 0.7 0.8 -0.14
Chronic Fatigue Syndrome 3.9 3 0.3
Chronic Kidney Disease 0.9 0.6 0.5
Chronic Lyme 0.2 -0.2
Chronic Obstructive Pulmonary Disease (COPD) 0.5 0.1 4
Chronic Urticaria (Hives) 0.4 0 0
Coagulation / Micro clot triggering bacteria 0.2 0.8 -3
Colorectal Cancer 1.1 0.7 0.57
Constipation 0.2 0.5 -1.5
Coronary artery disease 0.6 0.7 -0.17
COVID-19 6.2 6.3 -0.02
Crohn's Disease 2.4 2.2 0.09
cystic fibrosis 0.5 -0.5
deep vein thrombosis 0.4 -0.4
Depression 5.3 3.4 0.56
Dermatomyositis 0.1 0.3 -2
Eczema 0.4 0.4 0
Endometriosis 1.2 0.7 0.71
Eosinophilic Esophagitis 0.3 -0.3
Epilepsy 1.2 1.1 0.09
Fibromyalgia 1.4 0.4 2.5
Functional constipation / chronic idiopathic constipation 1.8 1.1 0.64
gallstone disease (gsd) 1.2 0.4 2
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.3 0.9 -2
Generalized anxiety disorder 0.5 1.1 -1.2
Glioblastoma 0.1 -0.1
Graves' disease 0.8 0.8 0
Halitosis 0.4 0.1 3
Hashimoto's thyroiditis 1.4 0.4 2.5
Hidradenitis Suppurativa 0.1 0.3 -2
High Histamine/low DAO 0.1 0.5 -4
hypercholesterolemia (High Cholesterol) 0.2 0 0
hyperglycemia 0 1.1 0
Hyperlipidemia (High Blood Fats) 0.5 0.2 1.5
hypersomnia 0.4 -0.4
hypertension (High Blood Pressure 1.1 2.9 -1.64
Hypothyroidism 1 -1
Hypoxia 0.3 0.3
IgA nephropathy (IgAN) 0.9 -0.9
Inflammatory Bowel Disease 1.6 3.6 -1.25
Insomnia 0.6 0.2 2
Intracranial aneurysms 0.9 0.2 3.5
Irritable Bowel Syndrome 1.5 1.3 0.15
Liver Cirrhosis 2 1.3 0.54
Long COVID 4.2 5 -0.19
Low bone mineral density 0.1 -0.1
Lung Cancer 0.3 0.8 -1.67
Mast Cell Issues / mastitis 0.1 0.5 -4
ME/CFS with IBS 1 1.5 -0.5
ME/CFS without IBS 1 1.1 -0.1
Menopause 1.5 1.5
Metabolic Syndrome 2.9 3.5 -0.21
Mood Disorders 6.3 3.6 0.75
multiple chemical sensitivity [MCS] 0.4 0.4 0
Multiple Sclerosis 2.8 1.3 1.15
Multiple system atrophy (MSA) 0.5 0.9 -0.8
neuropathic pain 0.6 -0.6
Neuropathy (all types) 0.5 0.5
neuropsychiatric disorders (PANDAS, PANS) 0.2 0.2
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.8 3.7 -3.63
NonCeliac Gluten Sensitivity 0.3 -0.3
Obesity 3.6 1.8 1
obsessive-compulsive disorder 2.3 1.7 0.35
Osteoarthritis 0.9 0.2 3.5
Osteoporosis 0.9 0.6 0.5
pancreatic cancer 0.3 0.3
Parkinson's Disease 1.1 1.4 -0.27
Polycystic ovary syndrome 0.9 1 -0.11
Postural orthostatic tachycardia syndrome 0.3 -0.3
Premenstrual dysphoric disorder 0.9 0.2 3.5
primary biliary cholangitis 0.1 0.2 -1
Psoriasis 1.9 0.7 1.71
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 2.4 1.3 0.85
Rosacea 0.8 0.1 7
Schizophrenia 3.3 1 2.3
scoliosis 0.2 -0.2
Sjögren syndrome 1.7 1.9 -0.12
Sleep Apnea 0.9 0.9 0
Slow gastric motility / Gastroparesis 0.6 0.3 1
Small Intestinal Bacterial Overgrowth (SIBO) 0.1 0.6 -5
Stress / posttraumatic stress disorder 0.8 1.3 -0.63
Systemic Lupus Erythematosus 1.6 1.2 0.33
Tic Disorder 0.4 0.6 -0.5
Tourette syndrome 0 0.1 0
Type 1 Diabetes 1.3 0.8 0.63
Type 2 Diabetes 2.9 2 0.45
Ulcerative colitis 1.1 1.2 -0.09
Unhealthy Ageing 2.1 0.9 1.33

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