🍽️ piretanide,(prescription)

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  1. Hypertension (High Blood Pressure): Piretanide belongs to a class of medications called diuretics, specifically loop diuretics. It works by increasing the excretion of sodium and water from the body, leading to a reduction in blood volume and subsequently lowering blood pressure. By decreasing the workload on the heart and reducing blood pressure, piretanide helps to prevent complications associated with hypertension, such as stroke, heart attack, and kidney damage.

  2. Edema (Fluid Retention): Piretanide is also used to treat edema associated with conditions such as congestive heart failure, liver cirrhosis, and renal dysfunction. By promoting diuresis (increased urine production), piretanide helps reduce excess fluid accumulation in the body tissues, leading to relief of symptoms such as swelling of the legs, ankles, and abdomen.

  3. Heart Failure: Piretanide may be prescribed as part of the treatment regimen for heart failure, particularly in cases where fluid overload is present. By reducing fluid retention and lowering blood pressure, piretanide helps to alleviate symptoms of heart failure such as shortness of breath, fatigue, and fluid buildup in the lungs.

  4. Renal Impairment: Piretanide is effective in managing fluid retention in patients with renal impairment, including chronic kidney disease and nephrotic syndrome. It helps to improve urine output and relieve the burden on the kidneys by promoting the excretion of excess sodium and water.

  5. Cirrhosis: In individuals with liver cirrhosis, piretanide may be used to manage ascites, which is the accumulation of fluid in the abdominal cavity. By increasing urine output, piretanide helps to reduce abdominal swelling and discomfort associated with ascites.

  6. Symptom Relief: Piretanide therapy can lead to symptomatic improvement in patients with hypertension and edema, including reduced swelling, improved breathing, and increased exercise tolerance. However, it is important to note that piretanide is typically used as part of a comprehensive treatment plan that may include other medications and lifestyle modifications.

  7. Electrolyte Imbalance: Piretanide, like other loop diuretics, can cause electrolyte imbalances, particularly hypokalemia (low potassium levels), hyponatremia (low sodium levels), and hypomagnesemia (low magnesium levels). Healthcare providers may monitor electrolyte levels periodically and recommend supplementation as needed to prevent complications.

  8. Dehydration: Excessive diuresis induced by piretanide can lead to dehydration, especially in elderly patients and those with preexisting renal dysfunction. Patients should be advised to maintain adequate fluid intake and report symptoms of dehydration such as thirst, dry mouth, dizziness, and decreased urine output.

  9. Drug Interactions: Piretanide may interact with other medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), ACE inhibitors, angiotensin II receptor blockers (ARBs), potassium-sparing diuretics, and lithium. Healthcare providers should review the patient's medication regimen carefully to avoid potential drug interactions and adjust doses as necessary.

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Data Contradictions β€” Limits of Certainity

Impacted of piretanide,(prescription) On Probiotics

Rank Probiotic Impact

Bacteria Impacted by piretanide,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Bilophila genus Decreases 👪 Source Study High Level Cause Brain Fog(Cognitive impairment)
Bacteroides genus Decreases 👪 Source Study
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
unclassified Negativicoccus no rank Decreases ⚗️ Source Study
Eggerthellales order Decreases ⚗️ Source Study
Bilophila wadsworthia species Decreases 📓 Source Study
Bacteroides xylanisolvens species Decreases 📓 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Negativicoccus sp. S5-A15 species Decreases ⚗️ Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Coriobacterineae suborder Decreases ⚗️ Source Study
Chlamydiae/Verrucomicrobia group superphylum Decreases ⚗️ Source Study

Impact of piretanide,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.3 0.3
Allergic Rhinitis (Hay Fever) 0.2 0.2
Allergy to milk products 0.2 0.2
Alzheimer's disease 0.5 0.8 -0.6
Ankylosing spondylitis 0.2 -0.2
Anorexia Nervosa 0.2 -0.2
Antiphospholipid syndrome (APS) 0.3 -0.3
Asthma 0.2 -0.2
Atrial fibrillation 0.2 0.5 -1.5
Autism 0.2 0.5 -1.5
Bipolar Disorder 0.5 0.5
Brain Trauma 0.2 -0.2
Carcinoma 0.5 0.2 1.5
Celiac Disease 0.2 0.5 -1.5
Cerebral Palsy 0.2 -0.2
Chronic Fatigue Syndrome 0.3 0.8 -1.67
Chronic Kidney Disease 0.2 0.2
Chronic Lyme 0.2 -0.2
Colorectal Cancer 0.2 0.2
Constipation 0.2 0.2
COVID-19 0.2 0.2 0
Crohn's Disease 0.5 0.2 1.5
cystic fibrosis 0.2 -0.2
Depression 0.5 0.2 1.5
Endometriosis 0.2 0.2
Epilepsy 0.2 0.2 0
Fibromyalgia 0.2 -0.2
Functional constipation / chronic idiopathic constipation 0.2 0.2 0
Generalized anxiety disorder 0.2 -0.2
Graves' disease 0.2 0.2
Halitosis 0.2 0.2
Hashimoto's thyroiditis 0.2 0.5 -1.5
Hidradenitis Suppurativa 0.3 0.3
hyperglycemia 0.2 -0.2
hypersomnia 0.3 -0.3
hypertension (High Blood Pressure 0.2 0.5 -1.5
Hypoxia 0.2 0.2
Inflammatory Bowel Disease 0.2 0.2 0
Insomnia 0.2 0.2 0
Intracranial aneurysms 0.2 0.2
Irritable Bowel Syndrome 0.2 0.2 0
Liver Cirrhosis 0.5 0.5 0
Long COVID 0.2 0.5 -1.5
ME/CFS with IBS 0.2 -0.2
ME/CFS without IBS 0.1 0.2 -1
Metabolic Syndrome 0.5 0.5 0
Mood Disorders 0.8 0.2 3
Multiple Sclerosis 0.3 0.2 0.5
neuropathic pain 0.2 -0.2
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.2 -0.2
Obesity 0.5 0.2 1.5
obsessive-compulsive disorder 0.2 0.2 0
Osteoarthritis 0.2 0.2
Osteoporosis 0.2 0.2 0
Parkinson's Disease 0.3 0.3
Polycystic ovary syndrome 0.2 0.2
Psoriasis 0.2 -0.2
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 0.5 0.2 1.5
Schizophrenia 0.5 0.5
scoliosis 0.3 -0.3
Sjögren syndrome 0.2 -0.2
Sleep Apnea 0.2 -0.2
Slow gastric motility / Gastroparesis 0.2 0.2
Stress / posttraumatic stress disorder 0.2 0.2 0
Systemic Lupus Erythematosus 0.5 0.5
Tourette syndrome 0.2 -0.2
Type 1 Diabetes 0.5 0.5
Type 2 Diabetes 0.5 0.2 1.5
Ulcerative colitis 0.2 0.5 -1.5
Unhealthy Ageing 0.5 0.5

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