Modelled supplements for Amyotrophic lateral sclerosis (ALS) Motor Neuron

Conventional Beliefs

  1. Antioxidants: Antioxidants such as vitamins C and E have been investigated for their potential to reduce oxidative stress, which is implicated in the progression of ALS. While research has not conclusively shown their effectiveness in slowing ALS progression, maintaining adequate levels of antioxidants through diet or supplements might be beneficial for overall health.

  2. Omega-3 Fatty Acids: Omega-3 fatty acids found in fish oil or certain plant sources possess anti-inflammatory properties. Some studies suggest that omega-3 supplementation might have a potential role in reducing inflammation and oxidative stress, which could be beneficial for individuals with ALS. However, evidence supporting their efficacy is limited.

  3. Vitamin D: Vitamin D deficiency has been associated with a higher risk of ALS. Some studies suggest that maintaining adequate vitamin D levels might have a neuroprotective effect and could potentially influence the risk or progression of ALS. However, more research is needed to establish a clear link.

  4. Probiotics: The gut microbiota's influence on overall health, including neurological conditions, has prompted research into the potential role of probiotics in ALS. While the exact mechanisms are not fully understood, maintaining a healthy gut microbiota through probiotics might have indirect effects on overall health. However, direct evidence linking probiotics to ALS prevention or treatment is lacking.

For an explanation of how this is generated, see this post

All suggestions from this page should be reviewed by your medical professionals. These are based on modelling and not clinical studies.

Based on family and lower taxonomy ranks (genus,species,strains) reported in studies, the list is here

Net Impact Modifier Citations
27.6 inulin (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
23.6 vitamin d   πŸ“πŸ½οΈ Dosages πŸ“š
21 fructo-oligosaccharides (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
20.7 Human milk oligosaccharides (prebiotic, Holigos, Stachyose)   πŸ“πŸ½οΈ Dosages πŸ“š
19.7 resveratrol (grape seed/polyphenols/red wine)   πŸ“πŸ½οΈ Dosages πŸ“š
18.1 soy   πŸ“πŸ½οΈ Dosages πŸ“š
17.2 arabinogalactan (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
15.5 wheat bran   πŸ“š
11.6 lactobacillus plantarum (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
11.2 wheat   πŸ“š
11 pomegranate   πŸ“πŸ½οΈ Dosages πŸ“š
10.7 Conjugated Linoleic Acid   πŸ“š
10.6 Cacao   πŸ“πŸ½οΈ Dosages πŸ“š
10.5 oligosaccharides (prebiotic)   πŸ“š
10.5 Dangshen   πŸ“š
9.7 bacillus subtilis (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
9.2 bifidobacterium longum (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
9.1 mediterranean diet   πŸ“š
9.1 Moringa Oleifera   πŸ“š
9 Limosilactobacillus fermentum (probiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
9 fasting   πŸ“š
8.8 Apigenin   πŸ“š
8.5 Lactobacillus Johnsonii (probiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
8.1 banana   πŸ“š
8.1 lactobacillus casei (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
8 Glucomannan   πŸ“πŸ½οΈ Dosages πŸ“š
8 Slippery Elm   πŸ“š
7.9 apple   πŸ“š
7.8 ketogenic diet   πŸ“š
7.6 gum arabic (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
7.4 partially hydrolysed guar gum (prebiotic)   πŸ“š
7.2 berberine   πŸ“πŸ½οΈ Dosages πŸ“š
7 Ursolic acid   πŸ“š
6.9 lactobacillus plantarum,xylooligosaccharides,(prebiotic) (probiotics)   πŸ“š
6.7 lactobacillus rhamnosus (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
6.7 barley,oat   πŸ“š
6.6 whey   πŸ“πŸ½οΈ Dosages πŸ“š
6.6 Astragalus   πŸ“š
6.4 lactobacillus acidophilus (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
6.3 lactobacillus sakei (probiotics)   πŸ“š
6.2 barley   πŸ“πŸ½οΈ Dosages πŸ“š
6.1 jerusalem artichoke (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
6.1 l-proline   πŸ“š
6.1 pectin   πŸ“š
6 Soymilk   πŸ“š
5.8 quercetin   πŸ“πŸ½οΈ Dosages πŸ“š
5.8 omega-3 fatty acids   πŸ“πŸ½οΈ Dosages πŸ“š
5.7 garlic (allium sativum)   πŸ“πŸ½οΈ Dosages πŸ“š
5.7 black raspberries   πŸ“πŸ½οΈ Dosages πŸ“š
5.6 Shen Ling Bai Zhu San   πŸ“š
5.4 Vitamin C (ascorbic acid)   πŸ“πŸ½οΈ Dosages πŸ“š
5.3 aspergillus oryzae   πŸ“š
5.2 bifidobacterium animalis lactis (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
5.2 vitamin a   πŸ“πŸ½οΈ Dosages πŸ“š
5.1 fat   πŸ“š
5 lactobacillus paracasei (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
5 vegetarians   πŸ“š
5 bifidobacterium lactis bb12 (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
4.9 oolong teas   πŸ“š
4.9 purple sweet potatoes   πŸ“š
4.8 Bromelain   πŸ“πŸ½οΈ Dosages πŸ“š
4.7 blueberry   πŸ“š
4.7 vegetable/fruit juice-based diets   πŸ“š
4.6 xylooligosaccharide (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
4.6 pea (fiber, protein)   πŸ“š
4.5 zinc   πŸ“πŸ½οΈ Dosages πŸ“š
4.5 vitamin b2,Riboflavin   πŸ“πŸ½οΈ Dosages πŸ“š
4.5 Rutin   πŸ“πŸ½οΈ Dosages πŸ“š
4.4 persimmon tannin   πŸ“š
4.4 fish oil   πŸ“πŸ½οΈ Dosages πŸ“š
4.3 cranberry bean flour   πŸ“š
4.2 lupin seeds (anaphylaxis risk, toxic if not prepared properly)   πŸ“š
4.2 Pistachio   πŸ“š
4.1 galacto-oligosaccharides (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
4 mulberry fruit polysaccharide   πŸ“š
4 mannooligosaccharide (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
4 GABA   πŸ“πŸ½οΈ Dosages πŸ“š
4 Sodium alginate   πŸ“πŸ½οΈ Dosages πŸ“š
3.9 whole grain,bran   πŸ“š
3.8 xylan (prebiotic)   πŸ“š
3.8 Alpha-Ketoglutarate   πŸ“š
3.8 bioflorin,enterococcus faecium sf 68,(probiotics)   πŸ“š
3.7 bifidobacterium pseudocatenulatum,(probiotics)   πŸ“š
3.7 grape polyphenols   πŸ“š
3.7 glycine   πŸ“πŸ½οΈ Dosages πŸ“š
3.6 Ginseng   πŸ“πŸ½οΈ Dosages πŸ“š
3.6 Pumpkin   πŸ“š
3.6 enterococcus faecium (probiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
3.6 Pulses   πŸ“š
3.6 ku ding cha tea   πŸ“š
3.5 oregano (origanum vulgare, oil) |   πŸ“š
3.5 corn   πŸ“š
3.5 genistein   πŸ“š
3.5 Manjistha (Rubia cordifolia)   πŸ“š
3.5 gluten   πŸ“š
3.5 Burdock Root   πŸ“š
3.3 sesame cake/meal   πŸ“š
3.3 high fiber diet   πŸ“š
3.3 almonds/ almond skins   πŸ“πŸ½οΈ Dosages πŸ“š
3.2 animal-based diet   πŸ“š
3.2 bifidobacterium catenulatum,(probiotics)   πŸ“š
3.2 pediococcus acidilactic (probiotic)   πŸ“š
3.1 Goji (berry,juice)   πŸ“š
3.1 bifidobacterium bifidum (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
3.1 grape seed extract   πŸ“πŸ½οΈ Dosages πŸ“š
3.1 l-glutamine   πŸ“πŸ½οΈ Dosages πŸ“š
3.1 emblica officinalis   πŸ“š
3 lactobacillus reuteri (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
2.9 lactobacillus rhamnosus gg (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
2.9 green tea   πŸ“š
2.9 grape fiber   πŸ“š
2.9 Codonopsis pilosula   πŸ“š
2.9 Kiwifruit   πŸ“š
2.9 Kaempferol   πŸ“š
2.8 Citrus Fruit Extract   πŸ“š
2.8 white button mushrooms   πŸ“š
2.8 melatonin supplement   πŸ“πŸ½οΈ Dosages πŸ“š
2.7 safflower oil   πŸ“š
2.7 fibre-rich macrobiotic ma-pi 2 diet   πŸ“š
2.7 cinnamon (oil. spice)   πŸ“πŸ½οΈ Dosages πŸ“š
2.7 fenugreek   πŸ“š
2.7 high-fat sucrose   πŸ“š
2.7 fruit/legume fibre   πŸ“š
2.7 Exercise   πŸ“š
2.7 plantago asiatica l.   πŸ“š
2.6 rye   πŸ“š
2.6 oolong tea polyphenols   πŸ“š
2.6 ginger   πŸ“š
2.6 palm kernel meal   πŸ“š
2.6 rhubarb   πŸ“š
2.5 noni   πŸ“πŸ½οΈ Dosages πŸ“š
2.5 Far infrared Sauna   πŸ“š
2.4 Bofutsushosan   πŸ“š
2.4 vsl#3 (probiotics)   πŸ“š
2.3 trametes versicolor(Turkey tail mushroom)   πŸ“š
2.3 glutamate   πŸ“š
2.3 sesame   πŸ“š
2.3 mannitol   πŸ“š
2.3 dietary phytoestrogens (isoflavones)   πŸ“š
2.3 Gluco-Oligosaccharides   πŸ“š
2.3 amaranth   πŸ“š
2.2 Vitamin E   πŸ“πŸ½οΈ Dosages πŸ“š
2.2 grapes   πŸ“š
2.2 triphala   πŸ“πŸ½οΈ Dosages πŸ“š
2.2 camellia   πŸ“š
2.1 oats   πŸ“š
2.1 Onion   πŸ“š
2.1 low protein diet   πŸ“š
2 bacillus amyloliquefaciens (probiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
2 spirulina(cyanobacteria)   πŸ“š
2 green-lipped mussel   πŸ“š
2 oligofructose-enriched inulin (prebiotic)   πŸ“š
2 Tryptophan   πŸ“πŸ½οΈ Dosages πŸ“š
1.9 whole-grain barley   πŸ“πŸ½οΈ Dosages πŸ“š
1.9 Akkermansia muciniphila (probiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
1.9 hou-po-da-huang-tang   πŸ“š
1.9 yogurt   πŸ“š
1.9 brown algae   πŸ“š
1.9 lactobacillus casei shirota (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
1.8 glycyrrhizic acid (licorice)   πŸ“πŸ½οΈ Dosages πŸ“š
1.8 propionate   πŸ“š
1.8 Caffeine   πŸ“š
1.8 buckwheat   πŸ“š
1.7 high amylose cornstarch   πŸ“š
1.7 rosmarinus officinalis,rosemary   πŸ“š
1.7 Whole Cow milk   πŸ“š
1.7 dietary fiber   πŸ“š
1.7 l-sorbose   πŸ“š
1.7 lactobacillus salivarius (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
1.7 resistant maltodextrin   πŸ“πŸ½οΈ Dosages πŸ“š
1.7 red wine   πŸ“πŸ½οΈ Dosages πŸ“š
1.7 Goat milk   πŸ“š
1.7 Papain   πŸ“š
1.6 magnesium   πŸ“πŸ½οΈ Dosages πŸ“š
1.6 bifidobacterium infantis,(probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
1.6 acetic acid   πŸ“š
1.6 chondrus crispus,red sea weed   πŸ“š
1.6 sarcodiotheca gaudichaudii (red sea weed)   πŸ“š
1.6 blackcurrant   πŸ“š
1.6 germinated barley food-stuff   πŸ“š
1.5 high red meat   πŸ“š
1.5 quercetin,resveratrol   πŸ“š
1.5 wormwood(artemisia)   πŸ“š
1.5 l-taurine   πŸ“πŸ½οΈ Dosages πŸ“š
1.5 lactobacillus brevis (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
1.5 Guaiacol (polyphenol)   πŸ“š
1.4 slow digestible carbohydrates   πŸ“š
1.4 low carbohydrate diet   πŸ“š
1.4 broccoli   πŸ“š
1.4 high resistant starch   πŸ“š
1.4 carob   πŸ“š
1.4 fucoidan   πŸ“πŸ½οΈ Dosages πŸ“š
1.3 punicic acid   πŸ“š
1.3 bean   πŸ“š
1.3 bacillus,lactobacillus,streptococcus,saccharomyces probiotic   πŸ“š
1.3 sodium butyrate   πŸ“š
1.2 resistant starch   πŸ“š
1.2 plantain bananas   πŸ“š
1.2 navy bean   πŸ“š
1.2 dates   πŸ“š
1.2 maize   πŸ“š
1.2 linseed(flaxseed)   πŸ“πŸ½οΈ Dosages πŸ“š
1.2 clostridium butyricum (probiotics),Miya,Miyarisan   πŸ“πŸ½οΈ Dosages πŸ“š
1.2 Theanine   πŸ“š
1.2 Bifidobacterium animalis   πŸ“š
1.2 wasabi   πŸ“š
1.2 Sauerkraut   πŸ“š
1.2 Beet   πŸ“š
1.2 Fucose   πŸ“š
1.1 Glucosamine   πŸ“š
1.1 chlorine   πŸ“š
1.1 Xanthan gum   πŸ“š
1.1 carrageenan   πŸ“š
1.1 Turmeric   πŸ“πŸ½οΈ Dosages πŸ“š
1.1 Rhodiola rosea (Rosavin)   πŸ“πŸ½οΈ Dosages πŸ“š
1.1 quinoa   πŸ“š
1.1 bifidobacterium breve (probiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
1.1 Cinnamaldehyde   πŸ“š
1.1 whole-grain wheat   πŸ“š
1.1 l-arginine   πŸ“πŸ½οΈ Dosages πŸ“š
1.1 chicory (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
1.1 bacillus subtilis natto (probiotics)   πŸ“š
1.1 lard   πŸ“š
1.1 polyphenols   πŸ“πŸ½οΈ Dosages πŸ“š
1.1 schisandra chinensis(magnolia berry or five-flavor-fruit)   πŸ“š
1 sunflower oil   πŸ“š
1 bacillus (probiotics)   πŸ“š
1 Artemisinin   πŸ“š
1 western diet   πŸ“š
1 Olive Oil   πŸ“š
1 Krill Oil   πŸ“πŸ½οΈ Dosages πŸ“š
0.9 Xanthohumol   πŸ“š
0.9 Baicalin   πŸ“š
0.9 Pineapple   πŸ“š
0.9 Miso   πŸ“š
0.9 lactobacillus rhamnosus gg,lactobacillus,rhamnosus,propionibacterium freudenreichii,bifidobacterium breve (probiotics)   πŸ“š
0.8 Ferric citrate   πŸ“š
0.8 avocado peel   πŸ“š
0.8 lupin kernel fiber (legume) (anaphylaxis risk, toxic if not prepared properly)   πŸ“š
0.8 bifidobacterium adolescentis,(probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
0.8 saccharomyces boulardii (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
0.8 low-fat high-complex carbohydrate diet   πŸ“š
0.8 lactobacillus gasseri (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
0.7 hypocaloric hyperproteic diet   πŸ“š
0.7 low fodmap diet   πŸ“š
0.7 Perilla frutescens(shiso)   πŸ“πŸ½οΈ Dosages πŸ“š
0.7 bifidobacterium longum bb536 (probiotics)   πŸ“š
0.7 bacillus coagulans (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
0.7 enterococcus durans (probiotics)   πŸ“š
0.7 nigella sativa seed (black cumin)   πŸ“πŸ½οΈ Dosages πŸ“š
0.7 symbioflor 2 e.coli probiotics   πŸ“š
0.7 hydrogenated palm oil   πŸ“š
0.7 Bell Pepper   πŸ“š
0.6 Pterostilbene   πŸ“š
0.6 Lithium   πŸ“š
0.6 Oyster Mushroom   πŸ“š
0.6 Sijunzi decoction   πŸ“š
0.6 Lentilactobacillus buchneri   πŸ“š
0.6 potatoes   πŸ“š
0.6 marijuana   πŸ“š
0.6 vitamin B7, biotin   πŸ“πŸ½οΈ Dosages πŸ“š
0.5 Methionine   πŸ“πŸ½οΈ Dosages πŸ“š
0.5 Cranberry   πŸ“š
0.5 rice bran   πŸ“š
-0.5 Cheese   πŸ“š
-0.5 Grapefruit seed extract   πŸ“š
-0.5 schinus molle (herb)   πŸ“š
-0.6 retinoic acid,(Vitamin A derivative)   πŸ“š
-0.6 cherry   πŸ“š
-0.6 starch-fed   πŸ“š
-0.6 Pediococcus pentosaceus   πŸ“š
-0.6 Apple skin   πŸ“š
-0.6 Prescript Assist (2018 Formula)   πŸ“š
-0.6 lactobacillus helveticus,lactobacillus rhamnosus (probiotics)   πŸ“š
-0.6 Fisetin   πŸ“πŸ½οΈ Dosages πŸ“š
-0.6 colostrum   πŸ“š
-0.7 peppermint (spice, oil)   πŸ“š
-0.7 red wine polyphenols   πŸ“πŸ½οΈ Dosages πŸ“š
-0.7 enriched butter diet   πŸ“š
-0.7 cvs maximum strength probiotic   πŸ“š
-0.7 chicken   πŸ“š
-0.7 diosmin,(polyphenol)   πŸ“πŸ½οΈ Dosages πŸ“š
-0.7 cruciferous vegetables (broccoli cabbage)   πŸ“š
-0.8 whole grain diet   πŸ“š
-0.8 Konjaku flour   πŸ“š
-0.8 extra virgin olive oil   πŸ“š
-0.8 coriander oil   πŸ“š
-0.8 lactobacillus kefiri (NOT KEFIR)   πŸ“š
-0.8 alcoholic beverages   πŸ“š
-0.9 ß-glucan   πŸ“πŸ½οΈ Dosages πŸ“š
-0.9 chaga (mushroom)   πŸ“š
-0.9 ethanol   πŸ“š
-0.9 annatto   πŸ“š
-0.9 PreforPro   πŸ“š
-0.9 bacillus laterosporus (probiotic)   πŸ“š
-1 rice   πŸ“š
-1 high-saturated fat diet   πŸ“š
-1 lacto-ovo-vegetarian diet   πŸ“š
-1.1 doenjang (fermented bean paste)   πŸ“š
-1.1 capsaicin (hot pepper)   πŸ“š
-1.1 Hesperidin (polyphenol)   πŸ“πŸ½οΈ Dosages πŸ“š
-1.1 Mangosteen   πŸ“š
-1.1 red alga Laurencia tristicha   πŸ“š
-1.1 Dendrobium officinale   πŸ“š
-1.2 low-fat diets   πŸ“š
-1.2 Umeboshi (Japanese Apricot or Prunus mume )   πŸ“š
-1.2 choline   πŸ“πŸ½οΈ Dosages πŸ“š
-1.2 fraxinus angustifolia,narrow-leafed ash   πŸ“š
-1.2 tannic acid   πŸ“š
-1.3 chitooligosaccharides (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
-1.4 syzygium aromaticum (clove)   πŸ“š
-1.4 mastic gum (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
-1.4 neem   πŸ“πŸ½οΈ Dosages πŸ“š
-1.4 Nicotine, Nicotine Patch   πŸ“š
-1.4 trachyspermum ammi, Ajwain   πŸ“š
-1.4 Carthamus tinctorius L,Safflower   πŸ“š
-1.4 camelina seed   πŸ“š
-1.4 Sumac(Rhus coriaria)   πŸ“š
-1.4 Leonurine   πŸ“š
-1.5 mutaflor escherichia coli nissle 1917 (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
-1.6 fruit   πŸ“š
-1.6 dairy   πŸ“š
-1.6 high beef diet   πŸ“š
-1.6 Sulforaphane (In broccoli sprouts,cauliflower, kale, cole crops, cabbage, collards, mustard, and cress)   πŸ“š
-1.7 polygonatum kingianum(Orange Flower Solomon's Seal.)   πŸ“š
-1.7 salt (sodium chloride)   πŸ“š
-1.7 Rhubarb Peony Decoction   πŸ“š
-1.8 high sugar diet   πŸ“š
-1.9 candida albicans (prescription)   πŸ“š
-1.9 Psyllium (Plantago Ovata Husk)   πŸ“πŸ½οΈ Dosages πŸ“š
-1.9 quebracho   πŸ“š
-1.9 Dextrin   πŸ“πŸ½οΈ Dosages πŸ“š
-2 Fish   πŸ“š
-2 walnuts   πŸ“πŸ½οΈ Dosages πŸ“š
-2.2 sorghum   πŸ“š
-2.2 Tudca   πŸ“πŸ½οΈ Dosages πŸ“š
-2.3 galla chinensis (herb)   πŸ“š
-2.3 brassica juncea   πŸ“š
-2.4 high-protein diet   πŸ“š
-2.4 Coenzyme Q10   πŸ“πŸ½οΈ Dosages πŸ“š
-2.8 Curcumin   πŸ“πŸ½οΈ Dosages πŸ“š
-2.8 Pork   πŸ“š
-2.9 rare meat   πŸ“š
-2.9 Boron (Organic Source)   πŸ“š
-3 refined wheat breads   πŸ“š
-3.1 bifidobacterium pseudocatenulatum li09,bifidobacterium catenulatum li10 (probiotics)   πŸ“š
-3.1 fluorine   πŸ“š
-3.3 brown rice   πŸ“š
-3.8 Vitamin B1,thiamine hydrochloride   πŸ“πŸ½οΈ Dosages πŸ“š
-5 gluten-free diet   πŸ“š
-14.2 high-fat diets   πŸ“š

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