Modelled supplements for primary biliary cholangitis

Conventional Beliefs

  1. Vitamin D and Calcium: Adequate levels of vitamin D and calcium are important for bone health. Individuals with PBC might be at an increased risk of osteoporosis due to liver damage. Therefore, supplements of vitamin D and calcium might be recommended to support bone health.

  2. Omega-3 Fatty Acids: Omega-3 fatty acids found in fish oil might have anti-inflammatory properties and potentially benefit individuals with liver conditions like PBC by reducing inflammation. However, evidence specific to PBC is limited.

  3. Antioxidants: Some individuals with liver conditions might explore antioxidant supplements like vitamin E or other antioxidants to support liver health. However, evidence supporting their effectiveness in managing PBC is limited, and high doses of some antioxidants may have adverse effects.

  4. Probiotics: While not directly related to PBC, maintaining a healthy gut microbiome might indirectly impact overall health and potentially influence inflammation. Some research suggests that probiotics might have a role in modulating the immune system and reducing inflammation, although specific effects on PBC require further investigation.

For an explanation of how this is generated, see this post

All suggestions from this page should be reviewed by your medical professionals. These are based on modelling and not clinical studies.

Based on family and lower taxonomy ranks (genus,species,strains) reported in studies, the list is here

Net Impact Modifier Citations
5.3 inulin (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
2.9 bifidobacterium longum (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
2.8 bacillus subtilis (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
2.6 wheat bran   πŸ“š
2.3 wheat   πŸ“š
2.3 lactobacillus reuteri (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
2.2 lactobacillus rhamnosus gg (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
2.1 barley   πŸ“πŸ½οΈ Dosages πŸ“š
2 Nicotine, Nicotine Patch   πŸ“š
1.9 glycine   πŸ“πŸ½οΈ Dosages πŸ“š
1.9 Fisetin   πŸ“πŸ½οΈ Dosages πŸ“š
1.9 lactobacillus casei (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
1.8 Vitamin E   πŸ“πŸ½οΈ Dosages πŸ“š
1.7 vegetable   πŸ“š
1.7 almonds/ almond skins   πŸ“πŸ½οΈ Dosages πŸ“š
1.6 omega-3 fatty acids   πŸ“πŸ½οΈ Dosages πŸ“š
1.5 Tryptophan   πŸ“πŸ½οΈ Dosages πŸ“š
1.4 salt (sodium chloride)   πŸ“š
1.4 lauric acid(fatty acid in coconut oil,in palm kernel oil,)   πŸ“š
1.4 arabinogalactan (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
1.4 bifidobacterium pseudocatenulatum,(probiotics)   πŸ“š
1.3 fructo-oligosaccharides (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
1.3 lactobacillus salivarius (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
1.3 oregano (origanum vulgare, oil) |   πŸ“š
1.3 vitamin a   πŸ“πŸ½οΈ Dosages πŸ“š
1.3 whey   πŸ“πŸ½οΈ Dosages πŸ“š
1.2 rhubarb   πŸ“š
1.2 sodium butyrate   πŸ“š
1.2 lactobacillus paracasei (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
1.2 fish oil   πŸ“πŸ½οΈ Dosages πŸ“š
1.2 garlic (allium sativum)   πŸ“πŸ½οΈ Dosages πŸ“š
1.2 animal-based diet   πŸ“š
1.1 bifidobacterium catenulatum,(probiotics)   πŸ“š
1.1 fasting   πŸ“š
1.1 brown rice   πŸ“š
1.1 Burdock Root   πŸ“š
1.1 Ursolic acid   πŸ“š
1 gluten   πŸ“š
1 Kale   πŸ“š
1 Conjugated Linoleic Acid   πŸ“š
1 whole grain,bran   πŸ“š
1 walnuts   πŸ“πŸ½οΈ Dosages πŸ“š
1 pea (fiber, protein)   πŸ“š
1 fruit/legume fibre   πŸ“š
1 polygonatum kingianum(Orange Flower Solomon's Seal.)   πŸ“š
1 fibre-rich macrobiotic ma-pi 2 diet   πŸ“š
1 koji aspergillus oryzae   πŸ“š
1 bifidobacterium infantis,(probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
1 bacillus (probiotics)   πŸ“š
1 barley,oat   πŸ“š
1 l-sorbose   πŸ“š
1 sunflower oil   πŸ“š
1 safflower oil   πŸ“š
1 pomegranate   πŸ“πŸ½οΈ Dosages πŸ“š
0.9 bifidobacterium animalis lactis (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
0.9 black raspberries   πŸ“πŸ½οΈ Dosages πŸ“š
0.9 high resistant starch   πŸ“š
0.9 ginko   πŸ“πŸ½οΈ Dosages πŸ“š
0.9 Pistachio   πŸ“š
0.9 Shen Ling Bai Zhu San   πŸ“š
0.8 Vitamin B   πŸ“š
0.8 western diet   πŸ“š
0.8 plantago asiatica l.   πŸ“š
0.8 carbohydrates   πŸ“š
0.8 genistein   πŸ“š
0.8 chrysanthemum morifolium   πŸ“š
0.8 lactobacillus plantarum,xylooligosaccharides,(prebiotic) (probiotics)   πŸ“š
0.7 moderate-carbohydrate diet   πŸ“š
0.7 lupin seeds (anaphylaxis risk, toxic if not prepared properly)   πŸ“š
0.7 glutamate   πŸ“š
0.7 white button mushrooms   πŸ“š
0.7 bifidobacterium bifidum (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
0.7 purple sweet potatoes   πŸ“š
0.7 Olive Oil   πŸ“š
0.6 Rutin   πŸ“πŸ½οΈ Dosages πŸ“š
0.6 low protein diet   πŸ“š
0.6 clostridium butyricum (probiotics),Miya,Miyarisan   πŸ“πŸ½οΈ Dosages πŸ“š
0.6 bifidobacterium adolescentis,(probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
0.6 bacillus subtilis natto (probiotics)   πŸ“š
0.6 lactobacillus rhamnosus (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
0.5 broccoli   πŸ“š
0.5 zinc   πŸ“πŸ½οΈ Dosages πŸ“š
-0.5 refined wheat breads   πŸ“š
-0.5 triphala   πŸ“πŸ½οΈ Dosages πŸ“š
-0.6 saccharomyces boulardii (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
-0.6 lactobacillus gasseri (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
-0.6 nuts   πŸ“š
-0.6 oligosaccharides (prebiotic)   πŸ“š
-0.6 emblica officinalis   πŸ“š
-0.6 alcoholic beverages   πŸ“š
-0.6 Baicalin   πŸ“š
-0.7 cannabinoids   πŸ“š
-0.7 apple   πŸ“š
-0.7 Hesperidin (polyphenol)   πŸ“πŸ½οΈ Dosages πŸ“š
-0.7 ß-glucan   πŸ“πŸ½οΈ Dosages πŸ“š
-0.7 ku ding cha tea   πŸ“š
-0.7 carboxymethyl cellulose (prebiotic)   πŸ“š
-0.8 quercetin   πŸ“πŸ½οΈ Dosages πŸ“š
-0.8 mediterranean diet   πŸ“š
-0.8 lard   πŸ“š
-0.8 pectin   πŸ“š
-0.8 lupin kernel fiber (legume) (anaphylaxis risk, toxic if not prepared properly)   πŸ“š
-0.8 N-Acetyl Cysteine (NAC),   πŸ“πŸ½οΈ Dosages πŸ“š
-0.9 Lentilactobacillus buchneri   πŸ“š
-0.9 low-fat high-complex carbohydrate diet   πŸ“š
-0.9 chitooligosaccharides (prebiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
-0.9 high-protein diet   πŸ“š
-0.9 bacillus coagulans (probiotics)   πŸ“πŸ½οΈ Dosages πŸ“š
-1 vitamin B7, biotin   πŸ“πŸ½οΈ Dosages πŸ“š
-1 Baking Soda, Sodium Bicarbonate   πŸ“š
-1 Slippery Elm   πŸ“š
-1 diosmin,(polyphenol)   πŸ“πŸ½οΈ Dosages πŸ“š
-1 retinoic acid,(Vitamin A derivative)   πŸ“š
-1 Arbutin (polyphenol)   πŸ“πŸ½οΈ Dosages πŸ“š
-1 Vitamin B6,pyridoxine hydrochloride   πŸ“πŸ½οΈ Dosages πŸ“š
-1 luteolin (flavonoid)   πŸ“πŸ½οΈ Dosages πŸ“š
-1.1 Vitamin B-12   πŸ“πŸ½οΈ Dosages πŸ“š
-1.1 Vitamin C (ascorbic acid)   πŸ“πŸ½οΈ Dosages πŸ“š
-1.1 vitamin b2,Riboflavin   πŸ“πŸ½οΈ Dosages πŸ“š
-1.2 bifidobacterium pseudocatenulatum li09,bifidobacterium catenulatum li10 (probiotics)   πŸ“š
-1.2 Caffeine   πŸ“š
-1.3 Vitamin B1,thiamine hydrochloride   πŸ“πŸ½οΈ Dosages πŸ“š
-1.3 lactobacillus rhamnosus gg,lactobacillus,rhamnosus,propionibacterium freudenreichii,bifidobacterium breve (probiotics)   πŸ“š
-1.4 xylan (prebiotic)   πŸ“š
-1.4 vegetable/fruit juice-based diets   πŸ“š
-1.5 red wine   πŸ“πŸ½οΈ Dosages πŸ“š
-1.6 fat   πŸ“š
-1.7 l-glutamine   πŸ“πŸ½οΈ Dosages πŸ“š
-1.7 enterococcus faecium (probiotic)   πŸ“πŸ½οΈ Dosages πŸ“š
-2.3 resveratrol (grape seed/polyphenols/red wine)   πŸ“πŸ½οΈ Dosages πŸ“š
-2.6 vitamin B3,niacin   πŸ“πŸ½οΈ Dosages πŸ“š
-2.7 gluten-free diet   πŸ“š

All suggestions are computed solely on their predicted microbiome impact. Safety, side-effects etc must be evaluated by your medical professionals before starting. Some items suggests have significant risk of adverse consequences for some people.

Special thanks to David F Morrison and Geert Van Houcke for doing Quality Assurance. Special thanks to Oliver Luk, B.Sc. (Biology) from BiomeSight for spot checking the coding of data from the US National Library of Medicine

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