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Respiratory Conditions: NAC is commonly used as a mucolytic agent to help break down and thin mucus in the airways. It is used in the treatment of respiratory conditions such as chronic obstructive pulmonary disease (COPD), bronchitis, and cystic fibrosis. NAC can help improve lung function, reduce coughing, and alleviate symptoms of respiratory congestion.
Antioxidant Properties: NAC acts as a precursor to glutathione, a powerful antioxidant in the body. By increasing glutathione levels, NAC helps protect cells from oxidative damage caused by free radicals. This antioxidant activity may contribute to its therapeutic effects in various conditions, including liver diseases, neurodegenerative disorders, and cardiovascular diseases.
Liver Health: NAC has hepatoprotective properties and is used in the management of acetaminophen (paracetamol) overdose-induced liver toxicity. It helps replenish glutathione stores in the liver, which are depleted during acetaminophen overdose, thereby reducing liver damage and improving outcomes.
Mental Health: NAC has been studied for its potential role in improving mental health and cognitive function. It may have antidepressant and anxiolytic effects by modulating glutamate neurotransmission, reducing inflammation, and promoting neuroplasticity. NAC supplementation has shown promise in alleviating symptoms of depression, bipolar disorder, and obsessive-compulsive disorder (OCD).
Addiction Treatment: NAC has been investigated for its potential in the treatment of substance use disorders, particularly cocaine and cannabis dependence. It may help reduce drug cravings, withdrawal symptoms, and drug-seeking behavior by modulating glutamate levels in the brain and restoring normal reward pathways.
Fertility Support: NAC supplementation has been suggested to improve fertility in both men and women. It may enhance sperm quality and motility in men with infertility issues. In women undergoing fertility treatments, NAC may improve ovulation and increase the chances of conception.
Cardiovascular Health: NAC may have cardiovascular benefits due to its antioxidant and anti-inflammatory properties. It may help reduce oxidative stress, lower blood pressure, improve endothelial function, and prevent plaque formation in the arteries. These effects could potentially reduce the risk of cardiovascular diseases such as heart disease and stroke.
Acetaminophen Overdose: As mentioned earlier, NAC is the antidote of choice for acetaminophen overdose. It works by replenishing depleted glutathione levels and preventing liver damage caused by toxic metabolites of acetaminophen. Early administration of NAC is critical for improving outcomes in cases of acetaminophen poisoning.
Rank | Probiotic | Impact |
---|---|---|
species | Enterococcus durans | Reduces |
species | Enterococcus faecalis | Reduces |
species | Enterococcus faecium | Reduces |
species group | Pseudomonas putida group | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
---|---|---|---|
Acne | 0.2 | 0.2 | |
ADHD | 1.2 | 1.2 | |
Age-Related Macular Degeneration and Glaucoma | 0.3 | 0.3 | |
Allergic Rhinitis (Hay Fever) | 1 | 1 | |
Allergies | 0.8 | 1.9 | -1.37 |
Allergy to milk products | 0.7 | 0.7 | |
Alopecia (Hair Loss) | 1 | 0.6 | 0.67 |
Alzheimer's disease | 1.9 | 2 | -0.05 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.5 | 0.2 | 1.5 |
Ankylosing spondylitis | 1 | 0.7 | 0.43 |
Anorexia Nervosa | 0.2 | 0.7 | -2.5 |
Antiphospholipid syndrome (APS) | 0.9 | 0.9 | |
Asthma | 0.3 | 1 | -2.33 |
Atherosclerosis | 0.2 | 0.2 | 0 |
Atrial fibrillation | 1.9 | 0.9 | 1.11 |
Autism | 2.8 | 3 | -0.07 |
Barrett esophagus cancer | 0.8 | 0.8 | |
Bipolar Disorder | 1 | 1.2 | -0.2 |
Brain Trauma | 1 | -1 | |
Carcinoma | 1.2 | 1.2 | 0 |
Celiac Disease | 1.4 | 1.4 | 0 |
Cerebral Palsy | 0.5 | 0.7 | -0.4 |
Chronic Fatigue Syndrome | 2.3 | 2.4 | -0.04 |
Chronic Kidney Disease | 0.5 | 0.7 | -0.4 |
Chronic Lyme | 0.5 | -0.5 | |
Chronic Urticaria (Hives) | 0.2 | -0.2 | |
Coagulation / Micro clot triggering bacteria | 0.6 | 0.2 | 2 |
Colorectal Cancer | 2.6 | 0.8 | 2.25 |
Constipation | 1.2 | 1.2 | |
Coronary artery disease | 0.2 | 0.6 | -2 |
COVID-19 | 4.7 | 5.3 | -0.13 |
Crohn's Disease | 2.2 | 2.1 | 0.05 |
cystic fibrosis | 1.8 | 0.5 | 2.6 |
deep vein thrombosis | 0.6 | 0.2 | 2 |
Depression | 2.9 | 2.6 | 0.12 |
Eczema | 0.5 | 0.2 | 1.5 |
Endometriosis | 1.3 | 0.2 | 5.5 |
Epilepsy | 1.8 | 0.7 | 1.57 |
Fibromyalgia | 0.5 | 0.7 | -0.4 |
Functional constipation / chronic idiopathic constipation | 1.6 | 1.4 | 0.14 |
gallstone disease (gsd) | 0.5 | 0.2 | 1.5 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.3 | 0.3 | |
Generalized anxiety disorder | 0.5 | 0.5 | 0 |
Gout | 1.1 | -1.1 | |
Graves' disease | 0.5 | 1.7 | -2.4 |
Halitosis | 0.5 | 0.2 | 1.5 |
Hashimoto's thyroiditis | 1 | 0.5 | 1 |
Hidradenitis Suppurativa | 0.5 | 0.2 | 1.5 |
Histamine Issues,Mast Cell Issue, DAO Insufficiency | 2 | 0 | 0 |
hypercholesterolemia (High Cholesterol) | 0.6 | 0.9 | -0.5 |
hyperglycemia | 0.7 | 0.5 | 0.4 |
Hyperlipidemia (High Blood Fats) | 0.2 | -0.2 | |
hypertension (High Blood Pressure | 1.8 | 3 | -0.67 |
Hypoxia | 0.5 | 0.5 | |
IgA nephropathy (IgAN) | 1.6 | -1.6 | |
Inflammatory Bowel Disease | 2.5 | 1.9 | 0.32 |
Insomnia | 0.5 | 0.5 | 0 |
Intelligence | 0.2 | 0.2 | |
Intracranial aneurysms | 0.7 | 0.7 | |
Irritable Bowel Syndrome | 2.6 | 2.3 | 0.13 |
Liver Cirrhosis | 2.7 | 2.4 | 0.13 |
Long COVID | 2.8 | 3.7 | -0.32 |
Low bone mineral density | 0.2 | -0.2 | |
Lung Cancer | 0.2 | 0.5 | -1.5 |
ME/CFS with IBS | 0.7 | 1.6 | -1.29 |
ME/CFS without IBS | 1.1 | 2 | -0.82 |
Menopause | 0.2 | 0.2 | |
Metabolic Syndrome | 4.1 | 4.1 | 0 |
Mood Disorders | 3.3 | 3.8 | -0.15 |
multiple chemical sensitivity [MCS] | 0.6 | 0.6 | |
Multiple Sclerosis | 1.2 | 1.1 | 0.09 |
Multiple system atrophy (MSA) | 0.2 | 0.2 | 0 |
neuropsychiatric disorders (PANDAS, PANS) | 1.1 | 1.1 | |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.3 | 1.8 | -5 |
Obesity | 3.8 | 2.5 | 0.52 |
obsessive-compulsive disorder | 2.5 | 1 | 1.5 |
Osteoarthritis | 0.5 | 0.2 | 1.5 |
Osteoporosis | 1.3 | 1.2 | 0.08 |
Parkinson's Disease | 0.9 | 0.8 | 0.13 |
Polycystic ovary syndrome | 0.7 | 1.8 | -1.57 |
primary biliary cholangitis | 0.3 | 0.8 | -1.67 |
Psoriasis | 1.8 | 0.7 | 1.57 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 4.2 | 3.5 | 0.2 |
Rosacea | 0.3 | 0.3 | |
Schizophrenia | 1 | 1.6 | -0.6 |
scoliosis | 0.2 | -0.2 | |
sensorineural hearing loss | 0.5 | 0.5 | |
Sjögren syndrome | 0.2 | 1.2 | -5 |
Sleep Apnea | 0.2 | 1.2 | -5 |
Small Intestinal Bacterial Overgrowth (SIBO) | 1.8 | 0.3 | 5 |
Stress / posttraumatic stress disorder | 1.8 | 1.5 | 0.2 |
Systemic Lupus Erythematosus | 1.2 | 0.7 | 0.71 |
Tic Disorder | 0.2 | 0.3 | -0.5 |
Tourette syndrome | 0.5 | -0.5 | |
Type 1 Diabetes | 1 | 0.5 | 1 |
Type 2 Diabetes | 2.8 | 2.6 | 0.08 |
Ulcerative colitis | 1.8 | 2.6 | -0.44 |
Unhealthy Ageing | 1.2 | 0.1 | 11 |
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