🍽️ Ferric citrate

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  1. Hyperphosphatemia in Chronic Kidney Disease (CKD): Ferric citrate is approved for the management of elevated phosphate levels in patients with CKD who are undergoing dialysis. In CKD, the kidneys are unable to adequately filter and excrete phosphate from the blood, leading to hyperphosphatemia. Elevated phosphate levels are associated with an increased risk of cardiovascular complications, bone disorders (e.g., renal osteodystrophy), and progression of CKD. Ferric citrate works by binding to dietary phosphate in the gastrointestinal tract, thereby reducing phosphate absorption and lowering serum phosphate levels.

  2. Iron Deficiency Anemia in CKD: Ferric citrate contains iron, which can help address iron deficiency anemia commonly observed in patients with CKD, particularly those undergoing dialysis. Iron deficiency anemia in CKD can result from blood loss during dialysis treatments, reduced iron absorption from the diet, and inflammation-induced alterations in iron metabolism. Ferric citrate provides a source of elemental iron, which is absorbed in the gastrointestinal tract and utilized for the production of red blood cells and hemoglobin. By replenishing iron stores, ferric citrate can improve hemoglobin levels and reduce the need for erythropoiesis-stimulating agents (ESAs) in patients with CKD-related anemia.

  3. Phosphate Binding Properties: In addition to its effects on phosphate levels, ferric citrate also functions as a phosphate binder in the gastrointestinal tract. By binding to dietary phosphate, ferric citrate helps prevent phosphate absorption from the gut, leading to reduced phosphate levels in the bloodstream. Controlling phosphate levels is important for managing mineral and bone disorders associated with CKD and reducing the risk of cardiovascular complications in affected individuals.

  4. Gastrointestinal Side Effects: Common side effects associated with ferric citrate therapy include gastrointestinal symptoms such as diarrhea, constipation, nausea, vomiting, abdominal pain, and flatulence. These side effects are typically mild to moderate in severity and often resolve with continued use or dose adjustments. Patients should be monitored for gastrointestinal adverse reactions while receiving ferric citrate and may require symptomatic management or dose modification as needed.

  5. Hypophosphatemia: In some cases, ferric citrate therapy may lead to hypophosphatemia (low phosphate levels) due to excessive phosphate binding in the gastrointestinal tract. Hypophosphatemia can occur if ferric citrate is administered at high doses or if dietary phosphate intake is inadequate. Monitoring of serum phosphate levels is essential during ferric citrate treatment to avoid excessive phosphate depletion and potential adverse effects on bone health and metabolism.

  6. Other Considerations: Patients with iron overload disorders (e.g., hemochromatosis) or hypersensitivity to ferric citrate or any of its components should not use this medication. Additionally, drug interactions may occur with certain medications, necessitating careful evaluation of concomitant medication regimens and potential adjustments.

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Data Contradictions β€” Limits of Certainity

Impacted of Ferric citrate On Probiotics

Rank Probiotic Impact
genus Pediococcus Reduces
species Akkermansia muciniphila Increases

Bacteria Impacted by Ferric citrate

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

πŸ§™?

Taxonomy Rank Effect Citations Notation
PVC group clade Increases 👪 Source Study
Methylacidiphilae class Increases 👶 Source Study
Opitutae class Increases 👶 Source Study
Spartobacteria class Increases 👶 Source Study
Terrimicrobiia class Increases 👶 Source Study
Verrucomicrobiae class Increases 👶 Source Study
Bifidobacteriaceae family Decreases 📓 Source Study
Lactobacillaceae family Decreases 📓 Source Study
Akkermansiaceae family Increases 👪 Source Study
Lachnospiraceae family Increases 👪 Source Study
Prevotellaceae family Increases 👪 Source Study
Clostridiaceae family Increases 📓 Source Study
Enterobacteriaceae family Increases 📓 Source Study
Sharpea genus Decreases 👶 Source Study
Acetilactobacillus genus Decreases 👶 Source Study
Aeriscardovia genus Decreases 👶 Source Study
Agrilactobacillus genus Decreases 👶 Source Study
Alloscardovia genus Decreases 👶 Source Study
Amylolactobacillus genus Decreases 👶 Source Study
Apilactobacillus genus Decreases 👶 Source Study
Bifidobacterium genus Decreases 👶 Source Study
Bombilactobacillus genus Decreases 👶 Source Study
Bombiscardovia genus Decreases 👶 Source Study
Companilactobacillus genus Decreases 👶 Source Study
Dellaglioa genus Decreases 👶 Source Study
Fructilactobacillus genus Decreases 👶 Source Study
Fructobacillus genus Decreases 👶 Source Study
Furfurilactobacillus genus Decreases 👶 Source Study
Galliscardovia genus Decreases 👶 Source Study
Gardnerella genus Decreases 👶 Source Study
Holzapfeliella genus Decreases 👶 Source Study
Lacticaseibacillus genus Decreases 👶 Source Study
Lactiplantibacillus genus Decreases 👶 Source Study
Lactobacillus genus Decreases 👶 Source Study Pathogen
Lapidilactobacillus genus Decreases 👶 Source Study
Latilactobacillus genus Decreases 👶 Source Study
Lentilactobacillus genus Decreases 👶 Source Study
Leuconostoc genus Decreases 👶 Source Study
Levilactobacillus genus Decreases 👶 Source Study
Ligilactobacillus genus Decreases 👶 Source Study
Limosilactobacillus genus Decreases 👶 Source Study
Liquorilactobacillus genus Decreases 👶 Source Study
Loigolactobacillus genus Decreases 👶 Source Study
Neoscardovia genus Decreases 👶 Source Study
Nicoliella genus Decreases 👶 Source Study
Oenococcus genus Decreases 👶 Source Study
Parascardovia genus Decreases 👶 Source Study
Paucilactobacillus genus Decreases 👶 Source Study
Pediococcus genus Decreases 👶 Source Study
Periweissella genus Decreases 👶 Source Study
Pseudoscardovia genus Decreases 👶 Source Study
Scardovia genus Decreases 👶 Source Study
Schleiferilactobacillus genus Decreases 👶 Source Study
Secundilactobacillus genus Decreases 👶 Source Study
Weissella genus Decreases 👶 Source Study
Alkaliphilus genus Increases 👶 Source Study
Anaerobacter genus Increases 👶 Source Study
Anoxynatronum genus Increases 👶 Source Study
Atlantibacter genus Increases 👶 Source Study
Beduini genus Increases 👶 Source Study
Buttiauxella genus Increases 👶 Source Study
Butyricicoccus genus Increases 👶 Source Study
Caloramator genus Increases 👶 Source Study
Caminicella genus Increases 👶 Source Study
Candidatus Arthromitus genus Increases 👶 Source Study
Candidatus Dwaynia genus Increases 👶 Source Study
Candidatus Ishikawaella genus Increases 👶 Source Study
Candidatus Moranella genus Increases 👶 Source Study
Candidatus Phlomobacter genus Increases 👶 Source Study
Candidatus Profftia genus Increases 👶 Source Study
Candidatus Riesia genus Increases 👶 Source Study
Candidatus Schneideria genus Increases 👶 Source Study
Cedecea genus Increases 👶 Source Study
Citrobacter genus Increases 👶 Source Study Pathogen
Clostridium genus Increases 👶 Source Study Pathogen
Crassaminicella genus Increases 👶 Source Study
Cronobacter genus Increases 👶 Source Study
Enterobacter genus Increases 👶 Source Study Urinary and respiratory infections
Entomohabitans genus Increases 👶 Source Study
Escherichia genus Increases 👶 Source Study
Falcatimonas genus Increases 👶 Source Study
Fervidicella genus Increases 👶 Source Study
Fonticella genus Increases 👶 Source Study
Franconibacter genus Increases 👶 Source Study
Geosporobacter genus Increases 👶 Source Study
Hathewaya genus Increases 👶 Source Study
Hungatella genus Increases 👶 Source Study
Jejubacter genus Increases 👶 Source Study
Kluyvera genus Increases 👶 Source Study
Kosakonia genus Increases 👶 Source Study
Lactonifactor genus Increases 👶 Source Study
Leclercia genus Increases 👶 Source Study
Lelliottia genus Increases 👶 Source Study
Lutispora genus Increases 👶 Source Study
Maledivibacter genus Increases 👶 Source Study
Mangrovibacter genus Increases 👶 Source Study
Massilioclostridium genus Increases 👶 Source Study
Metakosakonia genus Increases 👶 Source Study
Mordavella genus Increases 👶 Source Study
Natronincola genus Increases 👶 Source Study
Oceanirhabdus genus Increases 👶 Source Study
Oxobacter genus Increases 👶 Source Study
Paraclostridium genus Increases 👶 Source Study
Paramaledivibacter genus Increases 👶 Source Study
Phytobacter genus Increases 👶 Source Study
Plesiomonas genus Increases 👶 Source Study
Pluralibacter genus Increases 👶 Source Study
Proteiniclasticum genus Increases 👶 Source Study
Pseudescherichia genus Increases 👶 Source Study
Pseudocitrobacter genus Increases 👶 Source Study
Salmonella genus Increases 👶 Source Study Pathogen
Sarcina genus Increases 👶 Source Study
Scandinavium genus Increases 👶 Source Study
Senegalia genus Increases 👶 Source Study
Serpentinicella genus Increases 👶 Source Study
Shigella genus Increases 👶 Source Study Pathogen
Shimwellia genus Increases 👶 Source Study
Siccibacter genus Increases 👶 Source Study
Thermobrachium genus Increases 👶 Source Study
Thermotalea genus Increases 👶 Source Study
Tindallia genus Increases 👶 Source Study
Trabulsiella genus Increases 👶 Source Study
Yokenella genus Increases 👶 Source Study
Youngiibacter genus Increases 👶 Source Study
Biostraticola genus Increases 👶 Source Study
Brassicibacter genus Increases 👶 Source Study
Caldisalinibacter genus Increases 👶 Source Study
Candidatus Regiella genus Increases 👶 Source Study
Clostridiisalibacter genus Increases 👶 Source Study
Gibbsiella genus Increases 👶 Source Study
Keratinibaculum genus Increases 👶 Source Study
Klebsiella genus Increases 👶 Source Study Pathogen
Limnobaculum genus Increases 👶 Source Study
Raoultella genus Increases 👶 Source Study
Rosenbergiella genus Increases 👶 Source Study
Sporosalibacterium genus Increases 👶 Source Study
Thermohalobacter genus Increases 👶 Source Study
Akkermansia genus Increases 📓 Source Study
Prevotella genus Increases 📓 Source Study
Roseburia genus Increases 📓 Source Study
Enterobacteriaceae incertae sedis no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
Klebsiella/Raoultella group no rank Increases 👶 Source Study
unclassified Akkermansia no rank Increases 👶 Source Study
unclassified Clostridiaceae no rank Increases 👶 Source Study
unclassified Enterobacteriaceae no rank Increases 👶 Source Study
unclassified Prevotella no rank Increases 👶 Source Study
unclassified Roseburia no rank Increases 👶 Source Study
unclassified Verrucomicrobiota no rank Increases 👶 Source Study
Verrucomicrobiota incertae sedis no rank Increases 👶 Source Study
Bifidobacteriales order Decreases 👪 Source Study
Lactobacillales order Decreases 👪 Source Study
Enterobacterales order Increases 👪 Source Study
Eubacteriales order Increases 👪 Source Study
Verrucomicrobiota phylum Increases 📓 Source Study
Lactonifactor longoviformis species Increases ⚗️ Source Study
Akkermansia glycaniphila species Increases 👶 Source Study
Akkermansia sp. species Increases 👶 Source Study
Hallella bergensis species Increases 👶 Source Study
Hallella colorans species Increases 👶 Source Study
Hallella multisaccharivorax species Increases 👶 Source Study
Hallella seregens species Increases 👶 Source Study
Hoylesella buccalis species Increases 👶 Source Study Infectious bacteria
Hoylesella enoeca species Increases 👶 Source Study
Hoylesella loescheii species Increases 👶 Source Study
Hoylesella marshii species Increases 👶 Source Study
Hoylesella nanceiensis species Increases 👶 Source Study
Hoylesella oralis species Increases 👶 Source Study
Hoylesella pleuritidis species Increases 👶 Source Study
Hoylesella saccharolytica species Increases 👶 Source Study
Hoylesella shahii species Increases 👶 Source Study
Hoylesella timonensis species Increases 👶 Source Study Infectious bacteria
Leyella lascolaii species Increases 👶 Source Study
Leyella stercorea species Increases 👶 Source Study
Prevotella amnii species Increases 👶 Source Study
Prevotella aurantiaca species Increases 👶 Source Study
Prevotella bivia species Increases 👶 Source Study Infectious bacteria
Prevotella brevis species Increases 👶 Source Study
Prevotella conceptionensis species Increases 👶 Source Study
Prevotella corporis species Increases 👶 Source Study
Prevotella dentalis species Increases 👶 Source Study
Prevotella dentasini species Increases 👶 Source Study
Prevotella denticola species Increases 👶 Source Study
Prevotella disiens species Increases 👶 Source Study
Prevotella falsenii species Increases 👶 Source Study
Prevotella fusca species Increases 👶 Source Study
Prevotella herbatica species Increases 👶 Source Study
Prevotella histicola species Increases 👶 Source Study
Prevotella intermedia species Increases 👶 Source Study Infectious bacteria
Prevotella jejuni species Increases 👶 Source Study
Prevotella marseillensis species Increases 👶 Source Study
Prevotella melaninogenica species Increases 👶 Source Study Pathogen
Prevotella merdae species Increases 👶 Source Study
Prevotella micans species Increases 👶 Source Study
Prevotella multiformis species Increases 👶 Source Study
Prevotella nigrescens species Increases 👶 Source Study
Prevotella oryzae species Increases 👶 Source Study
Prevotella pallens species Increases 👶 Source Study
Prevotella pectinovora species Increases 👶 Source Study
Prevotella phocaeensis species Increases 👶 Source Study
Prevotella rara species Increases 👶 Source Study
Prevotella ruminicola species Increases 👶 Source Study
Prevotella scopos species Increases 👶 Source Study
Prevotella sp. species Increases 👶 Source Study
Prevotella sp. AM34-19LB species Increases 👶 Source Study
Prevotella sp. P5-108 species Increases 👶 Source Study
Prevotella sp. P5-119 species Increases 👶 Source Study
Prevotella veroralis species Increases 👶 Source Study
Roseburia cecicola species Increases 👶 Source Study
Roseburia faecis species Increases 👶 Source Study
Roseburia hominis species Increases 👶 Source Study
Roseburia intestinalis species Increases 👶 Source Study
Roseburia inulinivorans species Increases 👶 Source Study
Roseburia porci species Increases 👶 Source Study
Roseburia rectibacter species Increases 👶 Source Study
Roseburia sp. AF02-12 species Increases 👶 Source Study
Roseburia sp. AF12-17LB species Increases 👶 Source Study
Roseburia sp. AM16-25 species Increases 👶 Source Study
Roseburia yibonii species Increases 👶 Source Study
Roseburia zhanii species Increases 👶 Source Study
Segatella albensis species Increases 👶 Source Study
Segatella baroniae species Increases 👶 Source Study
Segatella bryantii species Increases 👶 Source Study
Segatella buccae species Increases 👶 Source Study
Segatella copri species Increases 👶 Source Study Over 70%ile Indicator of mycotoxin present
Segatella hominis species Increases 👶 Source Study
Segatella maculosa species Increases 👶 Source Study
Segatella oris species Increases 👶 Source Study Infectious bacteria
Segatella oulorum species Increases 👶 Source Study
Segatella paludivivens species Increases 👶 Source Study
Segatella salivae species Increases 👶 Source Study
Prevotella sp. BV3C7 species Increases 👶 Source Study
Prevotella sp. BV3P1 species Increases 👶 Source Study
Prevotella sp. HJM029 species Increases 👶 Source Study
Prevotella sp. oral taxon 299 species Increases 👶 Source Study
Prevotella sp. S4-10 species Increases 👶 Source Study
Prevotella sp. S8 F8 species Increases 👶 Source Study
Prevotella sp. Smarlab 121567 species Increases 👶 Source Study
Prevotella sp. WAL 2039G species Increases 👶 Source Study
Roseburia sp. species Increases 👶 Source Study
Roseburia sp. 1120 species Increases 👶 Source Study
Roseburia sp. 11SE38 species Increases 👶 Source Study
Roseburia sp. 11SE39 species Increases 👶 Source Study
Roseburia sp. 499 species Increases 👶 Source Study
Roseburia sp. DJF_RR73 species Increases 👶 Source Study
Roseburia sp. DJF_VR77 species Increases 👶 Source Study
Roseburia sp. MC_37 species Increases 👶 Source Study
Akkermansia muciniphila species Increases 📓 Source Study
Akkermansia muciniphila ATCC BAA-835 strain Increases 👶 Source Study
Chlamydiae/Verrucomicrobia group superphylum Increases ⚗️ Source Study

Impact of Ferric citrate on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.6 -0.6
Acne 0.8 0.6 0.33
ADHD 1.8 1.7 0.06
Age-Related Macular Degeneration and Glaucoma 0.3 0.6 -1
Allergic Rhinitis (Hay Fever) 1.5 -1.5
Allergies 2.5 2.7 -0.08
Allergy to milk products 1.7 2.5 -0.47
Alopecia (Hair Loss) 0.3 -0.3
Alzheimer's disease 3.4 4.3 -0.26
Amyotrophic lateral sclerosis (ALS) Motor Neuron 1.8 3 -0.67
Ankylosing spondylitis 2.4 3.3 -0.38
Anorexia Nervosa 1.8 0.9 1
Antiphospholipid syndrome (APS) 0.6 -0.6
Asthma 3 3 0
Atherosclerosis 1.9 0.6 2.17
Atrial fibrillation 2.3 0.8 1.87
Autism 6.5 6.2 0.05
benign prostatic hyperplasia 0.4 -0.4
Bipolar Disorder 1.4 1.4 0
Brain Trauma 2.2 1.5 0.47
Breast Cancer 0.2 -0.2
Carcinoma 0.2 1.2 -5
Celiac Disease 2 1.1 0.82
Cerebral Palsy 1.4 1.4 0
Chronic Fatigue Syndrome 1.3 1.6 -0.23
Chronic Kidney Disease 1.4 1.2 0.17
Chronic Lyme 0.6 0.6 0
Chronic Obstructive Pulmonary Disease (COPD) 0.6 0.9 -0.5
Chronic Urticaria (Hives) 1.6 0.7 1.29
Coagulation / Micro clot triggering bacteria 0.6 1 -0.67
Colorectal Cancer 0.4 3.1 -6.75
Constipation 1.5 1.8 -0.2
Coronary artery disease 0.5 0.9 -0.8
COVID-19 4.9 3.4 0.44
Crohn's Disease 4 5.1 -0.27
cystic fibrosis 0.6 0.6 0
deep vein thrombosis 0.6 1 -0.67
Depression 6 5.8 0.03
Dermatomyositis 0.2 -0.2
Eczema 0.8 2.8 -2.5
Endometriosis 0.6 3.2 -4.33
Eosinophilic Esophagitis 0.3 0.3
Epilepsy 2.3 3.3 -0.43
erectile dysfunction 0.3 -0.3
Fibromyalgia 0.7 1.4 -1
Functional constipation / chronic idiopathic constipation 2.3 3.2 -0.39
gallstone disease (gsd) 1.1 0.8 0.38
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.6 0.6 0
Generalized anxiety disorder 0.2 0.6 -2
giant cell arteritis 0.2 0.6 -2
Glioblastoma 0.9 0.9
Gout 0.3 0.3
Graves' disease 2.3 0.9 1.56
Halitosis 0.9 -0.9
Hashimoto's thyroiditis 1 2.4 -1.4
Hidradenitis Suppurativa 0.6 -0.6
Histamine Issues,Mast Cell Issue, DAO Insufficiency 1.3 -1.3
hypercholesterolemia (High Cholesterol) 0.6 1.1 -0.83
hyperglycemia 1.2 1.5 -0.25
Hyperlipidemia (High Blood Fats) 0.2 2.1 -9.5
hypersomnia 0.2 -0.2
hypertension (High Blood Pressure 3.2 2.4 0.33
Hypothyroidism 1.1 0.6 0.83
Hypoxia 0.8 0.6 0.33
IgA nephropathy (IgAN) 1 1.2 -0.2
Inflammatory Bowel Disease 3.8 2.4 0.58
Insomnia 1.4 1.1 0.27
Intelligence 1.1 0.5 1.2
Intracranial aneurysms 0.5 -0.5
Irritable Bowel Syndrome 3.5 5.1 -0.46
Liver Cirrhosis 2.5 4.2 -0.68
Long COVID 5.3 5 0.06
Low bone mineral density 0.9 0.9
Lung Cancer 1.2 0.6 1
ME/CFS with IBS 0.2 0.4 -1
ME/CFS without IBS 1 -1
Metabolic Syndrome 4.9 5.5 -0.12
Mood Disorders 6.6 7.8 -0.18
multiple chemical sensitivity [MCS] 0.2 0.6 -2
Multiple Sclerosis 2.4 2.6 -0.08
Multiple system atrophy (MSA) 0.2 1.6 -7
myasthenia gravis 1.2 1.2
Neuropathy (all types) 0.4 1.8 -3.5
neuropsychiatric disorders (PANDAS, PANS) 0.3 0.3
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 2.3 2.7 -0.17
NonCeliac Gluten Sensitivity 0.2 -0.2
Obesity 4.1 4.5 -0.1
obsessive-compulsive disorder 1.7 1.6 0.06
Osteoarthritis 0.7 -0.7
Osteoporosis 0.8 1.1 -0.38
Parkinson's Disease 4.6 4.2 0.1
Polycystic ovary syndrome 1.6 3.2 -1
Postural orthostatic tachycardia syndrome 1 -1
Premenstrual dysphoric disorder 0.4 0.4
primary biliary cholangitis 0.3 -0.3
Psoriasis 3.1 1.4 1.21
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 4.9 6.6 -0.35
Rosacea 1.2 0.4 2
Schizophrenia 2.3 3.7 -0.61
scoliosis 0.6 0.3 1
sensorineural hearing loss 0.3 0.3
Sjögren syndrome 1.1 1.4 -0.27
Sleep Apnea 1.1 0.8 0.38
Small Intestinal Bacterial Overgrowth (SIBO) 1.6 -1.6
Stress / posttraumatic stress disorder 2.4 2.4 0
Systemic Lupus Erythematosus 3.1 3.9 -0.26
Tic Disorder 1.5 0.8 0.88
Tourette syndrome 0.8 -0.8
Type 1 Diabetes 1.6 2.2 -0.38
Type 2 Diabetes 4.4 4.9 -0.11
Ulcerative colitis 7.2 2.7 1.67
Unhealthy Ageing 2 0.8 1.5

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