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Energy Metabolism: B vitamins play crucial roles as coenzymes in energy metabolism pathways, helping convert carbohydrates, fats, and proteins into energy. They are essential for the production of ATP (adenosine triphosphate), the body's primary energy currency.
Nervous System Function: Several B vitamins, including B1, B6, B9, and B12, are important for maintaining the health and function of the nervous system. They support nerve signaling, neurotransmitter synthesis, and myelin sheath formation, which helps protect and insulate nerve fibers.
Red Blood Cell Formation: B vitamins such as B6, B9, and B12 are necessary for the production of red blood cells (erythropoiesis). They play roles in DNA synthesis and folate metabolism, which are essential for the maturation of red blood cells in the bone marrow.
DNA Synthesis and Repair: B vitamins, particularly folate (B9) and cobalamin (B12), are involved in DNA synthesis and repair processes. They contribute to cell division and growth, and adequate levels of these vitamins are crucial during periods of rapid cell proliferation, such as pregnancy and infancy.
Cardiovascular Health: Certain B vitamins, such as niacin (B3), folate (B9), and cobalamin (B12), play roles in maintaining cardiovascular health. They help regulate homocysteine metabolism, which, when elevated, is associated with an increased risk of cardiovascular disease.
Skin and Hair Health: Biotin (B7) is often associated with promoting healthy skin, hair, and nails. It plays a role in fatty acid synthesis and is involved in maintaining the integrity of skin cells. Biotin deficiency can lead to symptoms such as dermatitis, alopecia (hair loss), and brittle nails.
Mood Regulation: B vitamins, particularly folate (B9) and cobalamin (B12), are involved in neurotransmitter synthesis, including serotonin and dopamine, which play roles in mood regulation. Deficiencies in these vitamins have been linked to mood disorders such as depression and anxiety.
Digestive Health: B vitamins, such as riboflavin (B2), niacin (B3), and pantothenic acid (B5), are important for maintaining digestive health. They play roles in digestive enzyme synthesis, gut microbiota metabolism, and mucosal integrity.
Bone Health: Some B vitamins, including folate (B9), cobalamin (B12), and pyridoxine (B6), are involved in bone metabolism. They contribute to the synthesis of collagen and other proteins in bone tissue and play roles in calcium and vitamin D metabolism.
Eye Health: Certain B vitamins, such as riboflavin (B2) and niacin (B3), are important for maintaining eye health. They contribute to antioxidant defense mechanisms and help protect against oxidative damage to ocular tissues.
| Rank | Probiotic | Impact |
|---|
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Acne | 1.8 | 0.6 | 2 |
| ADHD | 2.2 | 0.6 | 2.67 |
| Age-Related Macular Degeneration and Glaucoma | 0.6 | 0.4 | 0.5 |
| Allergies | 1.2 | 1.4 | -0.17 |
| Allergy to milk products | 0.6 | -0.6 | |
| Alopecia (Hair Loss) | 1.5 | -1.5 | |
| Alzheimer's disease | 3.1 | 0.4 | 6.75 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.9 | 1.6 | -0.78 |
| Ankylosing spondylitis | 0.8 | 1 | -0.25 |
| Anorexia Nervosa | 2.5 | 0.3 | 7.33 |
| Asthma | 0.5 | 0.6 | -0.2 |
| Atherosclerosis | 0.2 | 0.2 | |
| Atrial fibrillation | 0.6 | 1.6 | -1.67 |
| Autism | 3.5 | 1.8 | 0.94 |
| benign prostatic hyperplasia | 0.2 | 0.2 | |
| Bipolar Disorder | 0.7 | 0.3 | 1.33 |
| Brain Trauma | 0.2 | 0.3 | -0.5 |
| Breast Cancer | 0.2 | -0.2 | |
| Carcinoma | 0.6 | 0.6 | 0 |
| Celiac Disease | 2.1 | 0.8 | 1.63 |
| Cerebral Palsy | 0.6 | 0.6 | |
| Chronic Fatigue Syndrome | 1.8 | 0.8 | 1.25 |
| Chronic Kidney Disease | 1.7 | 1.7 | |
| Chronic Lyme | 0.2 | 0.2 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 0.8 | 0.8 | 0 |
| Chronic Urticaria (Hives) | 0.2 | 0.2 | |
| Coagulation / Micro clot triggering bacteria | 1.4 | 0.6 | 1.33 |
| Colorectal Cancer | 0.2 | 2.2 | -10 |
| Constipation | 0.4 | 0.8 | -1 |
| Coronary artery disease | 1.6 | 0.8 | 1 |
| COVID-19 | 3.5 | 2.1 | 0.67 |
| Crohn's Disease | 3.6 | 1.8 | 1 |
| cystic fibrosis | 0.2 | 0.2 | |
| deep vein thrombosis | 1 | 1 | |
| Depression | 3.6 | 2.4 | 0.5 |
| Dermatomyositis | 0.3 | 0.4 | -0.33 |
| Endometriosis | 0.4 | 0.9 | -1.25 |
| Eosinophilic Esophagitis | 1.1 | 1.1 | |
| Epilepsy | 1.1 | 2.4 | -1.18 |
| erectile dysfunction | 0.8 | -0.8 | |
| Fibromyalgia | 0.6 | 1 | -0.67 |
| Functional constipation / chronic idiopathic constipation | 0.9 | 1.5 | -0.67 |
| gallstone disease (gsd) | 0.2 | 0.6 | -2 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 1.1 | -1.1 | |
| Generalized anxiety disorder | 0.2 | 0.4 | -1 |
| Glioblastoma | 0.8 | 0.8 | |
| Gout | 0.8 | 0.8 | |
| Graves' disease | 2.6 | 0.2 | 12 |
| Halitosis | 0.4 | 0.3 | 0.33 |
| Hashimoto's thyroiditis | 0.2 | 1.6 | -7 |
| Hidradenitis Suppurativa | 0.5 | 0.5 | |
| Histamine Issues,Mast Cell Issue, DAO Insufficiency | 0.8 | 0.6 | 0.33 |
| hypercholesterolemia (High Cholesterol) | 0.3 | -0.3 | |
| hyperglycemia | 0.2 | 0.6 | -2 |
| hypersomnia | 0.2 | 0.2 | |
| hypertension (High Blood Pressure | 1.8 | 1.8 | |
| Hypothyroidism | 1.6 | 1.6 | |
| IgA nephropathy (IgAN) | 0.6 | -0.6 | |
| Inflammatory Bowel Disease | 1.9 | 1.1 | 0.73 |
| Insomnia | 0.7 | 0.4 | 0.75 |
| Intelligence | 1 | -1 | |
| Intracranial aneurysms | 0.8 | 0.4 | 1 |
| Irritable Bowel Syndrome | 1.3 | 1.8 | -0.38 |
| Juvenile idiopathic arthritis | 0.3 | 0.6 | -1 |
| Liver Cirrhosis | 0.6 | 1.6 | -1.67 |
| Long COVID | 4 | 3.1 | 0.29 |
| Low bone mineral density | 1.2 | 0.4 | 2 |
| Lung Cancer | 1.8 | 1.8 | |
| ME/CFS without IBS | 0.2 | 0.2 | |
| Metabolic Syndrome | 3.1 | 1.7 | 0.82 |
| Mood Disorders | 3.8 | 3.4 | 0.12 |
| multiple chemical sensitivity [MCS] | 0.2 | 0.2 | |
| Multiple Sclerosis | 1.3 | 1 | 0.3 |
| Multiple system atrophy (MSA) | 0.2 | 0.2 | |
| myasthenia gravis | 0.2 | -0.2 | |
| Neuropathy (all types) | 1.3 | -1.3 | |
| neuropsychiatric disorders (PANDAS, PANS) | 0.9 | 0.9 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 1.2 | 1.8 | -0.5 |
| Obesity | 3 | 1.5 | 1 |
| obsessive-compulsive disorder | 1.8 | 0.4 | 3.5 |
| Osteoarthritis | 0.3 | 0.6 | -1 |
| Osteoporosis | 0.7 | 0.7 | |
| Parkinson's Disease | 3.6 | 0.8 | 3.5 |
| Polycystic ovary syndrome | 0.2 | 0.8 | -3 |
| Postural orthostatic tachycardia syndrome | 0.2 | 0.2 | 0 |
| Premenstrual dysphoric disorder | 0.2 | 0.4 | -1 |
| primary biliary cholangitis | 0.8 | -0.8 | |
| Psoriasis | 0.6 | 0.5 | 0.2 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 2.1 | 2.5 | -0.19 |
| Rosacea | 0.5 | 0.5 | |
| Schizophrenia | 1.1 | 2.3 | -1.09 |
| scoliosis | 0.8 | -0.8 | |
| sensorineural hearing loss | 0.6 | 0.6 | |
| Sjögren syndrome | 1.2 | 0.7 | 0.71 |
| Sleep Apnea | 0.8 | 0.7 | 0.14 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.3 | 0.3 | |
| Stress / posttraumatic stress disorder | 1.3 | 0.6 | 1.17 |
| Systemic Lupus Erythematosus | 3.1 | 0.6 | 4.17 |
| Tic Disorder | 0.2 | 0.2 | |
| Type 1 Diabetes | 0.4 | 1.5 | -2.75 |
| Type 2 Diabetes | 2.1 | 1.7 | 0.24 |
| Ulcerative colitis | 2.4 | 1.1 | 1.18 |
| Unhealthy Ageing | 0.6 | 0.2 | 2 |
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