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Digestive Health: Bifidobacterium breve contributes to maintaining a healthy balance of gut bacteria, which is essential for digestive health. It helps in the digestion and absorption of nutrients, production of beneficial compounds like short-chain fatty acids, and inhibition of harmful bacteria in the gut. This can help alleviate symptoms of digestive disorders such as irritable bowel syndrome (IBS), diarrhea, and constipation.
Immune Function: Bifidobacterium breve has been shown to support immune function by enhancing the activity of immune cells and promoting the production of certain immune factors. By modulating the immune response, it may help the body defend against infections and reduce the risk of immune-related conditions.
Allergic Conditions: Some studies suggest that Bifidobacterium breve may have a role in preventing and managing allergic conditions such as eczema and allergic rhinitis. It helps regulate the immune response, reduce inflammation, and strengthen the gut barrier, which can help alleviate symptoms of allergic reactions.
Antibiotic-Associated Diarrhea: Bifidobacterium breve has been researched for its ability to prevent antibiotic-associated diarrhea (AAD). By replenishing beneficial bacteria in the gut disrupted by antibiotics, it may help maintain normal bowel function and reduce the incidence of diarrhea associated with antibiotic use.
Vaginal Health: Bifidobacterium breve is naturally present in the vaginal microbiota and plays a role in maintaining vaginal health by preventing the overgrowth of harmful bacteria and yeast. Supplementation with Bifidobacterium breve may help restore microbial balance and reduce the risk of vaginal infections such as bacterial vaginosis and yeast infections.
Respiratory Health: Some evidence suggests that Bifidobacterium breve may have a protective effect on respiratory health. It may help reduce the severity and duration of respiratory infections such as the common cold and flu by modulating immune responses and promoting the production of antiviral compounds.
Infant Health: Bifidobacterium breve is commonly found in breast milk and is an important colonizer of the infant gut. It plays a crucial role in the development of the infant's immune system, digestion, and overall health. Supplementation with Bifidobacterium breve may help reduce the risk of digestive issues, allergies, and infections in infants.
| Rank | Probiotic | Impact |
|---|---|---|
| genus | Bifidobacterium | Increases |
| species | Akkermansia muciniphila | Increases |
| species | Bacteroides uniformis | Reduces |
| species | Bifidobacterium adolescentis | Increases |
| species | Bifidobacterium animalis | Increases |
| species | Bifidobacterium bifidum | Increases |
| species | Bifidobacterium breve | Increases |
| species | Bifidobacterium catenulatum | Increases |
| species | Bifidobacterium longum | Increases |
| species | Bifidobacterium pseudocatenulatum | Increases |
| species | Bifidobacterium pseudolongum | Increases |
| species | Blautia hansenii | Reduces |
| species | Blautia wexlerae | Reduces |
| species | Odoribacter laneus | Increases |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Acne | 1.2 | 1.2 | |
| ADHD | 1.2 | 3.3 | -1.75 |
| Age-Related Macular Degeneration and Glaucoma | 0.3 | 0.3 | |
| Allergic Rhinitis (Hay Fever) | 3 | 3 | |
| Allergies | 2.3 | 2.1 | 0.1 |
| Allergy to milk products | 2.2 | 1.6 | 0.38 |
| Alopecia (Hair Loss) | 0.9 | 0 | 0 |
| Alzheimer's disease | 5 | 5 | 0 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 2 | 3.1 | -0.55 |
| Ankylosing spondylitis | 2.5 | 2.8 | -0.12 |
| Anorexia Nervosa | 1.1 | 1.6 | -0.45 |
| Antiphospholipid syndrome (APS) | 0.3 | 0.3 | |
| Asthma | 1.8 | 1.8 | 0 |
| Atherosclerosis | 0.8 | 1.8 | -1.25 |
| Atrial fibrillation | 2.2 | 3 | -0.36 |
| Autism | 5.9 | 7.1 | -0.2 |
| benign prostatic hyperplasia | 0.6 | 0.6 | |
| Biofilm | 0.2 | -0.2 | |
| Bipolar Disorder | 2 | 1.4 | 0.43 |
| Brain Trauma | 0.7 | 1.4 | -1 |
| Cancer (General) | 0.4 | 0.8 | -1 |
| Carcinoma | 3 | 2.8 | 0.07 |
| Celiac Disease | 4 | 2.3 | 0.74 |
| Cerebral Palsy | 0.6 | 2.2 | -2.67 |
| Chronic Fatigue Syndrome | 3.6 | 2.1 | 0.71 |
| Chronic Kidney Disease | 1.5 | 1.5 | |
| Chronic Lyme | 0.5 | 0.5 | 0 |
| Chronic Obstructive Pulmonary Disease (COPD) | 0.9 | 0 | 0 |
| Chronic Urticaria (Hives) | 0.6 | 1 | -0.67 |
| Coagulation / Micro clot triggering bacteria | 1.4 | 0.5 | 1.8 |
| Colorectal Cancer | 2.8 | 2.4 | 0.17 |
| Constipation | 2.4 | 0.8 | 2 |
| Coronary artery disease | 0.8 | 1.1 | -0.38 |
| COVID-19 | 8.1 | 6.3 | 0.29 |
| Crohn's Disease | 6.3 | 5.1 | 0.24 |
| cystic fibrosis | 1.4 | 1.1 | 0.27 |
| deep vein thrombosis | 1.3 | 1.3 | |
| Depression | 7.5 | 6.3 | 0.19 |
| Dermatomyositis | 0.6 | 0.6 | |
| Eczema | 2 | 0.2 | 9 |
| Endometriosis | 3 | 2.4 | 0.25 |
| Epilepsy | 3.9 | 2.8 | 0.39 |
| erectile dysfunction | 0.3 | 0 | 0 |
| Fibromyalgia | 1.7 | 0.8 | 1.13 |
| Functional constipation / chronic idiopathic constipation | 3.7 | 3.2 | 0.16 |
| gallstone disease (gsd) | 1.4 | 1.2 | 0.17 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.3 | 0.3 | 0 |
| Generalized anxiety disorder | 2.2 | 0.5 | 3.4 |
| Glioblastoma | 0.3 | 0.3 | |
| Gout | 0.9 | 0.9 | |
| Graves' disease | 0.5 | 2.6 | -4.2 |
| Halitosis | 0.5 | 0.5 | |
| Hashimoto's thyroiditis | 1.6 | 1.7 | -0.06 |
| Hemorrhoidal disease, Hemorrhoids, Piles | 0.3 | 0.6 | -1 |
| High Histamine/low DAO | 2.2 | 2.2 | |
| hypercholesterolemia (High Cholesterol) | 0.2 | 0.6 | -2 |
| hyperglycemia | 1.7 | 1.3 | 0.31 |
| Hyperlipidemia (High Blood Fats) | 1.8 | -1.8 | |
| hypersomnia | 0.2 | 0.5 | -1.5 |
| hypertension (High Blood Pressure | 4.2 | 3.9 | 0.08 |
| Hypothyroidism | 2.1 | 0.8 | 1.63 |
| Hypoxia | 0.5 | 0.6 | -0.2 |
| IgA nephropathy (IgAN) | 1.9 | 0.7 | 1.71 |
| Inflammatory Bowel Disease | 4.8 | 2.5 | 0.92 |
| Insomnia | 1.3 | 1.5 | -0.15 |
| Intelligence | 0.7 | 1.7 | -1.43 |
| Intracranial aneurysms | 1 | 0.9 | 0.11 |
| Irritable Bowel Syndrome | 3.5 | 3.5 | 0 |
| Juvenile idiopathic arthritis | 0.6 | -0.6 | |
| Liver Cirrhosis | 4.4 | 3.5 | 0.26 |
| Long COVID | 6.9 | 5.6 | 0.23 |
| Low bone mineral density | 1.1 | 1.1 | |
| Lung Cancer | 1.6 | 0.5 | 2.2 |
| Mast Cell Issues / mastitis | 2.9 | 2.9 | |
| ME/CFS with IBS | 1 | 0.7 | 0.43 |
| ME/CFS without IBS | 0.8 | 0.5 | 0.6 |
| Menopause | 0.6 | 0.4 | 0.5 |
| Metabolic Syndrome | 7.8 | 6.4 | 0.22 |
| Mood Disorders | 7.8 | 8.4 | -0.08 |
| multiple chemical sensitivity [MCS] | 1.1 | -1.1 | |
| Multiple Sclerosis | 1.6 | 4.3 | -1.69 |
| Multiple system atrophy (MSA) | 1.4 | 1.3 | 0.08 |
| myasthenia gravis | 0.5 | -0.5 | |
| neuropathic pain | 0.6 | 0.5 | 0.2 |
| Neuropathy (all types) | 0.5 | 0.8 | -0.6 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.3 | 0.6 | -1 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 5.3 | 1.8 | 1.94 |
| NonCeliac Gluten Sensitivity | 1.1 | 2.2 | -1 |
| Obesity | 7.6 | 4.7 | 0.62 |
| obsessive-compulsive disorder | 4.8 | 2 | 1.4 |
| Osteoarthritis | 1.5 | 0 | 0 |
| Osteoporosis | 1 | 1.6 | -0.6 |
| pancreatic cancer | 0.9 | -0.9 | |
| Parkinson's Disease | 5.1 | 5.8 | -0.14 |
| Polycystic ovary syndrome | 3.8 | 0.6 | 5.33 |
| Postural orthostatic tachycardia syndrome | 1.7 | 1.7 | |
| Premenstrual dysphoric disorder | 0.5 | 0.6 | -0.2 |
| primary biliary cholangitis | 0.3 | 0.4 | -0.33 |
| Psoriasis | 1.5 | 3.1 | -1.07 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 4.2 | 5.7 | -0.36 |
| Rosacea | 2.2 | -2.2 | |
| Schizophrenia | 3.6 | 4.8 | -0.33 |
| scoliosis | 0.6 | 0.9 | -0.5 |
| sensorineural hearing loss | 0 | 0 | |
| Sjögren syndrome | 2.5 | 1.8 | 0.39 |
| Sleep Apnea | 2.6 | 3.1 | -0.19 |
| Slow gastric motility / Gastroparesis | 1.3 | 0.6 | 1.17 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.9 | 0.3 | 2 |
| Stress / posttraumatic stress disorder | 4 | 1.9 | 1.11 |
| Systemic Lupus Erythematosus | 5.1 | 2.2 | 1.32 |
| Tic Disorder | 0.6 | 1.5 | -1.5 |
| Tourette syndrome | 0.3 | 1.1 | -2.67 |
| Type 1 Diabetes | 1.9 | 1.8 | 0.06 |
| Type 2 Diabetes | 6.3 | 6.4 | -0.02 |
| Ulcerative colitis | 5.3 | 3.3 | 0.61 |
| Unhealthy Ageing | 4.2 | 0.6 | 6 |
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