🍽️ isovaleric acid(fatty acid)

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  1. Isovaleric Acidemia (IVA): Isovaleric acidemia is a rare genetic metabolic disorder characterized by a deficiency of the enzyme isovaleryl-CoA dehydrogenase, which is involved in the metabolism of leucine. As a result, individuals with isovaleric acidemia are unable to properly break down leucine, leading to the accumulation of isovaleric acid and its derivatives in the body. High levels of isovaleric acid can be toxic and cause a range of symptoms, including metabolic acidosis, vomiting, poor feeding, lethargy, developmental delays, seizures, and a distinctive odor resembling sweaty feet or cheese. Without prompt treatment, isovaleric acidemia can lead to life-threatening complications such as metabolic crises and neurological damage.

  2. Ketoacidosis: In individuals with isovaleric acidemia or other metabolic disorders associated with impaired leucine metabolism, the accumulation of isovaleric acid and its metabolites can disrupt normal metabolic processes and lead to ketoacidosis. Ketoacidosis is a serious condition characterized by elevated levels of ketones and acidic pH in the blood, which can cause symptoms such as rapid breathing, fruity-scented breath, confusion, and coma if left untreated. Ketoacidosis requires immediate medical intervention to correct metabolic imbalances and prevent complications.

  3. Odor Disorders: The distinctive odor associated with isovaleric acidemia, often described as "sweaty feet" or "cheesy," is caused by the accumulation of isovaleric acid and its derivatives in the body. This odor may be present in the sweat, urine, breath, and body secretions of affected individuals and can be a characteristic feature used for diagnostic purposes. However, it is important to note that not all individuals with isovaleric acidemia may exhibit this odor, and other factors may contribute to body odor in different individuals.

  4. Treatment: Management of isovaleric acidemia typically involves dietary restrictions to limit the intake of leucine and other branched-chain amino acids, as well as supplementation with special medical formulas designed to provide essential nutrients while minimizing the accumulation of toxic metabolites. In some cases, medications such as carnitine or antibiotics may be used to help manage symptoms and prevent metabolic crises. Regular monitoring of metabolic parameters, nutritional status, and growth is essential to optimize outcomes and prevent long-term complications in individuals with isovaleric acidemia.

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Impacted of isovaleric acid(fatty acid) On Probiotics

Rank Probiotic Impact

Bacteria Impacted by isovaleric acid(fatty acid)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Fusobacteriia class Increases 👶 Source Study
Betaproteobacteria class Increases 📓 Source Study
Leptotrichiaceae family Increases ⚗️ Source Study
Methanomassiliicoccaceae family Increases ⚗️ Source Study
Balneicellaceae family Increases 👶 Source Study
Muribaculaceae family Increases 👶 Source Study
Paludibacteraceae family Increases 👶 Source Study
Salinivirgaceae family Increases 👶 Source Study
Tenuifilaceae family Increases 👶 Source Study
Bacteroidaceae family Increases 📓 Source Study
Barnesiellaceae family Increases 📓 Source Study
Dysgonomonadaceae family Increases 📓 Source Study
Marinifilaceae family Increases 📓 Source Study
Marinilabiliaceae family Increases 📓 Source Study
Odoribacteraceae family Increases 📓 Source Study
Porphyromonadaceae family Increases 📓 Source Study
Prevotellaceae family Increases 📓 Source Study
Prolixibacteraceae family Increases 📓 Source Study
Rikenellaceae family Increases 📓 Source Study
Tannerellaceae family Increases 📓 Source Study
Anaerorhabdus genus Decreases 👶 Source Study
Acetobacteroides genus Increases 👶 Source Study
Alkaliflexus genus Increases 👶 Source Study
Alkalitalea genus Increases 👶 Source Study
Anaerocella genus Increases 👶 Source Study
Anaerophaga genus Increases 👶 Source Study
Aquipluma genus Increases 👶 Source Study
Breznakibacter genus Increases 👶 Source Study
Candidatus Azobacteroides genus Increases 👶 Source Study
Candidatus Vestibaculum genus Increases 👶 Source Study
Carboxylicivirga genus Increases 👶 Source Study
Culturomica genus Increases 👶 Source Study
Draconibacterium genus Increases 👶 Source Study
Dysgonomonas genus Increases 👶 Source Study
Falsiporphyromonas genus Increases 👶 Source Study
Fermentimonas genus Increases 👶 Source Study
Gabonia genus Increases 👶 Source Study
Gabonibacter genus Increases 👶 Source Study
Geofilum genus Increases 👶 Source Study
Hallella genus Increases 👶 Source Study
Hoylesella genus Increases 👶 Source Study
Labilibacter genus Increases 👶 Source Study
Labilibaculum genus Increases 👶 Source Study
Lascolabacillus genus Increases 👶 Source Study
Leyella genus Increases 👶 Source Study
Macellibacteroides genus Increases 👶 Source Study
Mangroviflexus genus Increases 👶 Source Study
Maribellus genus Increases 👶 Source Study
Marinifilum genus Increases 👶 Source Study
Marinilabilia genus Increases 👶 Source Study
Mariniphaga genus Increases 👶 Source Study
Massiliprevotella genus Increases 👶 Source Study
Mediterranea genus Increases 👶 Source Study
Meniscus genus Increases 👶 Source Study
Metaprevotella genus Increases 👶 Source Study
Microbacter genus Increases 👶 Source Study
Millionella genus Increases 👶 Source Study
Mucinivorans genus Increases 👶 Source Study
Odoribacter genus Increases 👶 Source Study
Petrimonas genus Increases 👶 Source Study
Phocaeicola genus Increases 👶 Source Study
Prevotellamassilia genus Increases 👶 Source Study
Prolixibacter genus Increases 👶 Source Study
Proteiniphilum genus Increases 👶 Source Study
Pseudoprevotella genus Increases 👶 Source Study
Rikenella genus Increases 👶 Source Study
Roseimarinus genus Increases 👶 Source Study
Ruminofilibacter genus Increases 👶 Source Study
Saccharicrinis genus Increases 👶 Source Study
Sanguibacteroides genus Increases 👶 Source Study
Segatella genus Increases 👶 Source Study
Sunxiuqinia genus Increases 👶 Source Study
Tangfeifania genus Increases 👶 Source Study
Tannerella genus Increases 👶 Source Study
Thermophagus genus Increases 👶 Source Study
Tidjanibacter genus Increases 👶 Source Study
unclassified Megasphaera no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Increases ⚗️ Source Study
Betaproteobacteria incertae sedis no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
unclassified Betaproteobacteria no rank Increases 👶 Source Study
unclassified Marinifilaceae no rank Increases 👶 Source Study
unclassified Odoribacteraceae no rank Increases 👶 Source Study
unclassified Porphyromonadaceae no rank Increases 👶 Source Study
unclassified Prevotellaceae no rank Increases 👶 Source Study
Bacteroidales incertae sedis no rank Increases 📓 Source Study
Burkholderiales order Increases 👶 Source Study
Ferrovales order Increases 👶 Source Study
Neisseriales order Increases 👶 Source Study
Nitrosomonadales order Increases 👶 Source Study
Rhodocyclales order Increases 👶 Source Study
Marinilabiliales order Increases 👪 Source Study
Bacteroidales order Increases 📓 Source Study
Pseudomonadota phylum Increases 👪 Source Study
Fusobacteriota phylum Increases 📓 Source Study
Coprobacter fastidiosus species Increases ⚗️ Source Study
Paraprevotella clara species Increases ⚗️ Source Study
Bacteria superkingdom Increases 👪 Source Study

Impact of isovaleric acid(fatty acid) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Acne 0.3 -0.3
ADHD 0.6 1.7 -1.83
Allergic Rhinitis (Hay Fever) 0.9 0.6 0.5
Allergies 0.6 -0.6
Allergy to milk products 0.9 0.9
Alopecia (Hair Loss) 0.3 -0.3
Alzheimer's disease 0.6 0.3 1
Amyotrophic lateral sclerosis (ALS) Motor Neuron 1.4 -1.4
Ankylosing spondylitis 0.6 2.1 -2.5
Anorexia Nervosa 0.6 -0.6
Asthma 1.5 -1.5
Atherosclerosis 0.2 0.2
Atrial fibrillation 0.8 0.2 3
Autism 2.9 1.1 1.64
Barrett esophagus cancer 0.3 -0.3
Bipolar Disorder 0.6 -0.6
Brain Trauma 1.2 1.2
Cancer (General) 0.5 -0.5
Carcinoma 0.2 0.2 0
Celiac Disease 1 0.5 1
Chronic Fatigue Syndrome 0.6 2.4 -3
Chronic Kidney Disease 0.3 -0.3
Chronic Urticaria (Hives) 0.3 -0.3
Colorectal Cancer 0.6 2.2 -2.67
Constipation 0.6 1.5 -1.5
COVID-19 2.4 2.3 0.04
Crohn's Disease 0.2 0.5 -1.5
Depression 3.5 3.7 -0.06
Dermatomyositis 0.3 -0.3
Eczema 1.2 -1.2
Endometriosis 0.2 0.3 -0.5
Eosinophilic Esophagitis 0.3 -0.3
Epilepsy 1.7 -1.7
Functional constipation / chronic idiopathic constipation 0.9 1.5 -0.67
gallstone disease (gsd) 0.3 -0.3
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 1.1 -1.1
Generalized anxiety disorder 0.6 0.3 1
giant cell arteritis 0.6 -0.6
Gout 1.8 -1.8
Graves' disease 0.6 1.8 -2
Halitosis 0.2 -0.2
Hemorrhoidal disease, Hemorrhoids, Piles 0.2 -0.2
High Histamine/low DAO 0.6 0.6
hypercholesterolemia (High Cholesterol) 0.2 -0.2
hyperglycemia 0.6 -0.6
Hyperlipidemia (High Blood Fats) 1.2 0.3 3
hypersomnia 0.6 0.6
hypertension (High Blood Pressure 0.2 1.3 -5.5
Inflammatory Bowel Disease 1.5 -1.5
Insomnia 0.9 0.6 0.5
Intelligence 1.2 1.2
Intracranial aneurysms 0.8 0.8
Irritable Bowel Syndrome 1.5 -1.5
Juvenile idiopathic arthritis 0.6 -0.6
Liver Cirrhosis 0.2 -0.2
Long COVID 4.6 2.7 0.7
Lung Cancer 1.2 1.2
Mast Cell Issues / mastitis 1.5 0.3 4
Metabolic Syndrome 0.8 1.3 -0.63
Mood Disorders 3.7 4.9 -0.32
Multiple Sclerosis 0.6 0.3 1
Neuropathy (all types) 0.3 0.3
neuropsychiatric disorders (PANDAS, PANS) 1.4 -1.4
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 1.4 1.1 0.27
Obesity 1.8 1.1 0.64
obsessive-compulsive disorder 0.2 0.3 -0.5
Osteoporosis 0.6 0.6 0
pancreatic cancer 0.2 -0.2
Parkinson's Disease 0.6 0.9 -0.5
Polycystic ovary syndrome 0.8 0.9 -0.13
primary biliary cholangitis 0.2 -0.2
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 1.6 1.7 -0.06
Rosacea 0.3 0.3
Schizophrenia 1.1 1.7 -0.55
sensorineural hearing loss 0.6 -0.6
Sjögren syndrome 0.3 0.2 0.5
Sleep Apnea 0.6 0.6
Systemic Lupus Erythematosus 2.3 2.3 0
Tic Disorder 0.6 0.2 2
Type 1 Diabetes 0.3 0.9 -2
Type 2 Diabetes 0.9 1.1 -0.22
Ulcerative colitis 2 0.5 3
Unhealthy Ageing 0.2 0.2

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