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Histamine Production: L-histidine is a precursor to histamine, a neurotransmitter and inflammatory mediator involved in various physiological processes, including immune responses, allergic reactions, and neurotransmission. Histamine plays a crucial role in the body's defense against pathogens and helps regulate processes such as gastric acid secretion, vasodilation, and neurotransmitter release. L-histidine availability may influence histamine levels in the body, which can impact immune function, allergic responses, and inflammatory conditions.
Allergic Disorders: Histamine is involved in allergic reactions and hypersensitivity responses triggered by allergens such as pollen, dust mites, animal dander, and certain foods. Histamine release from mast cells and basophils can lead to symptoms such as itching, sneezing, nasal congestion, hives, and asthma. L-histidine supplementation may influence histamine synthesis and metabolism, potentially modulating allergic responses and reducing the severity of allergic symptoms in individuals with allergic disorders such as allergic rhinitis, asthma, eczema, and food allergies.
Immune Function: L-histidine plays a role in regulating immune function and inflammatory responses. Histamine, derived from L-histidine, is involved in the activation and recruitment of immune cells, such as mast cells, eosinophils, and T cells, to sites of infection or tissue injury. Histamine helps initiate and coordinate immune responses against pathogens and foreign invaders. L-histidine availability may affect histamine-mediated immune responses and modulate inflammatory conditions such as autoimmune diseases, rheumatoid arthritis, and inflammatory bowel disease.
Neurotransmitter Function: Histamine acts as a neurotransmitter in the central nervous system and plays a role in regulating various brain functions, including wakefulness, arousal, appetite, mood, and cognitive processes. Histamine receptors are distributed throughout the brain and are involved in neurotransmission pathways implicated in conditions such as anxiety, depression, schizophrenia, and attention-deficit/hyperactivity disorder (ADHD). L-histidine availability may influence histamine levels in the brain, affecting neurotransmitter balance and neuronal activity.
Gastric Acid Secretion: Histamine stimulates the secretion of gastric acid from parietal cells in the stomach, playing a key role in the regulation of gastric acid production and gastric pH. Histamine H2 receptors on parietal cells mediate the stimulatory effect of histamine on gastric acid secretion. Drugs that block histamine H2 receptors, known as H2 receptor antagonists (H2 blockers), are commonly used to treat conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and gastritis. L-histidine availability may influence histamine synthesis and gastric acid secretion, although more research is needed to understand its clinical significance.
| Rank | Probiotic | Impact |
|---|
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Allergic Rhinitis (Hay Fever) | 0.2 | -0.2 | |
| Crohn's Disease | 0.2 | -0.2 | |
| Depression | 0.2 | 0.2 | |
| Liver Cirrhosis | 0.2 | -0.2 | |
| Long COVID | 1 | 1 | |
| Metabolic Syndrome | 0.2 | -0.2 | |
| Mood Disorders | 0.2 | 0.2 | |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 0.2 | -0.2 | |
| Type 2 Diabetes | 0.2 | -0.2 |
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