🍽️ melatonin supplement

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  1. Sleep Disorders: Melatonin supplements are primarily used to improve sleep quality and treat sleep disorders, including insomnia, delayed sleep phase disorder, and jet lag. Melatonin helps regulate the body's internal clock, promoting the onset of sleep and maintaining sleep duration. It can be particularly beneficial for individuals who have difficulty falling asleep or staying asleep.

  2. Jet Lag: Melatonin supplements are often used to alleviate the symptoms of jet lag, which occur when traveling across multiple time zones disrupts the body's circadian rhythm. By adjusting the timing of melatonin supplementation according to the destination time zone, individuals can help synchronize their internal clock with the new time schedule, reducing the severity and duration of jet lag symptoms.

  3. Shift Work Sleep Disorder: Melatonin supplements may be beneficial for individuals who work night shifts or irregular schedules and experience difficulty sleeping during the day. By promoting sleep onset and enhancing sleep quality, melatonin can help mitigate the negative effects of shift work on sleep patterns and overall well-being.

  4. Insomnia in Children with Neurodevelopmental Disorders: Melatonin supplements have been studied for their efficacy in improving sleep quality and reducing insomnia symptoms in children with neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Melatonin supplementation may help regulate sleep-wake cycles and improve sleep continuity in these populations.

  5. Sleep Disturbances in Older Adults: Melatonin levels naturally decline with age, leading to changes in sleep patterns and an increased prevalence of sleep disturbances in older adults. Melatonin supplements may help address age-related sleep problems by promoting the onset of sleep and enhancing sleep quality.

  6. Antioxidant and Anti-inflammatory Effects: Melatonin exhibits antioxidant and anti-inflammatory properties, which may contribute to its potential health benefits beyond sleep regulation. Melatonin supplementation has been studied for its protective effects against oxidative stress, inflammation, and cellular damage associated with various medical conditions, including cardiovascular disease, neurodegenerative disorders, and cancer.

  7. Headache Disorders: Some research suggests that melatonin supplements may be beneficial for individuals with certain headache disorders, such as migraine and cluster headaches. Melatonin's role in regulating circadian rhythms and modulating pain perception may help reduce the frequency, severity, and duration of headaches in some individuals.

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Data Contradictions β€” Limits of Certainity

Impacted of melatonin supplement On Probiotics

Rank Probiotic Impact
species Akkermansia muciniphila Increases
species Bifidobacterium adolescentis Reduces
species Bifidobacterium longum Reduces
species Escherichia coli Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by melatonin supplement

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

πŸ§™?

Taxonomy Rank Effect Citations Notation
Terrabacteria group clade Decreases 👪 Source Study
Bacteroidota/Chlorobiota group clade Increases 👪 Source Study
Bacilli class Decreases 👶 Source Study
Clostridia class Decreases 👶 Source Study
Desulfuribacillia class Decreases 👶 Source Study
Dethiobacteria class Decreases 👶 Source Study
Erysipelotrichia class Decreases 👶 Source Study
Limnochordia class Decreases 👶 Source Study
Negativicutes class Decreases 👶 Source Study
Thermolithobacteria class Decreases 👶 Source Study
Tissierellia class Decreases 👶 Source Study
Bacteroidia class Increases 👶 Source Study
Chitinophagia class Increases 👶 Source Study
Cytophagia class Increases 👶 Source Study
Flavobacteriia class Increases 👶 Source Study
Saprospiria class Increases 👶 Source Study
Sphingobacteriia class Increases 👶 Source Study
Actinomycetaceae family Decreases 👪 Source Study
Aeromonadaceae family Decreases 👪 Source Study
Peptoniphilaceae family Decreases 👪 Source Study
Clostridiales Family XI. Incertae Sedis family Decreases ⚗️ Source Study
Akkermansiaceae family Increases 👪 Source Study
Enterobacteriaceae family Increases 📓 Source Study
Lachnospiraceae family Increases 📓 Source Study
Verrucomicrobiaceae family Increases 📓 Source Study
Verrucomicrobiaceae family Increases 📓 Source Study
Aeromonas genus Decreases 📓 Source Study Pathogen
Finegoldia genus Decreases 📓 Source Study
Schaalia genus Decreases 📓 Source Study
Collinsella genus Decreases 👪 Source Study proinflammatory
Blautia genus Decreases 👪 Source Study
Clostridioides genus Decreases 👪 Source Study
Akkermansia genus Decreases 👪 Source Study
Lachnospira genus Decreases 👪 Source Study
Dorea genus Decreases 👪 Source Study
Bifidobacterium genus Decreases 👪 Source Study
Escherichia genus Decreases 👪 Source Study
Ruminococcus genus Decreases 👪 Source Study
Fusobacterium genus Decreases 👪 Source Study Periodontal disease, Lemierre syndrome, skin ulcers
Thomasclavelia genus Decreases 👪 Source Study
Veillonella genus Decreases 👪 Source Study
Bacteroides genus Decreases 👪 Source Study
Streptococcus genus Decreases 👪 Source Study
Odoribacter genus Decreases 👪 Source Study
Mediterraneibacter genus Decreases 👪 Source Study
Clostridium genus Decreases 👪 Source Study Pathogen
Roseburia genus Decreases 👪 Source Study
Lacrimispora genus Decreases 👪 Source Study
Bilophila genus Decreases 👪 Source Study High Level Cause Brain Fog(Cognitive impairment)
Phocaeicola genus Decreases 👪 Source Study
Acetatifactor genus Increases 👶 Source Study
Acetitomaculum genus Increases 👶 Source Study
Agathobacter genus Increases 👶 Source Study
Anaerobium genus Increases 👶 Source Study
Anaerobutyricum genus Increases 👶 Source Study
Anaerocolumna genus Increases 👶 Source Study
Anaeromicropila genus Increases 👶 Source Study
Anaeropeptidivorans genus Increases 👶 Source Study
Anaerosacchariphilus genus Increases 👶 Source Study
Anaerosporobacter genus Increases 👶 Source Study
Anaerostipes genus Increases 👶 Source Study
Anaerotaenia genus Increases 👶 Source Study
Anaerotignum genus Increases 👶 Source Study
Atlantibacter genus Increases 👶 Source Study
Bariatricus genus Increases 👶 Source Study
Blautia genus Increases 👶 Source Study
Brevifollis genus Increases 👶 Source Study
Brevifollis genus Increases 👶 Source Study
Buttiauxella genus Increases 👶 Source Study
Butyribacter genus Increases 👶 Source Study
Butyrivibrio genus Increases 👶 Source Study
Candidatus Epulonipiscium genus Increases 👶 Source Study
Candidatus Ishikawaella genus Increases 👶 Source Study
Candidatus Moranella genus Increases 👶 Source Study
Candidatus Phlomobacter genus Increases 👶 Source Study
Candidatus Profftia genus Increases 👶 Source Study
Candidatus Riesia genus Increases 👶 Source Study
Candidatus Schneideria genus Increases 👶 Source Study
Catenibacillus genus Increases 👶 Source Study
Catonella genus Increases 👶 Source Study
Cedecea genus Increases 👶 Source Study
Chordicoccus genus Increases 👶 Source Study
Citrobacter genus Increases 👶 Source Study Pathogen
Coprococcus genus Increases 👶 Source Study
Cronobacter genus Increases 👶 Source Study
Cuneatibacter genus Increases 👶 Source Study
Dorea genus Increases 👶 Source Study
Eisenbergiella genus Increases 👶 Source Study
Enterobacter genus Increases 👶 Source Study Urinary and respiratory infections
Enterocloster genus Increases 👶 Source Study
Entomohabitans genus Increases 👶 Source Study
Escherichia genus Increases 👶 Source Study
Extibacter genus Increases 👶 Source Study
Faecalicatena genus Increases 👶 Source Study
Faecalimonas genus Increases 👶 Source Study
Franconibacter genus Increases 👶 Source Study
Frisingicoccus genus Increases 👶 Source Study
Fucophilus genus Increases 👶 Source Study
Fucophilus genus Increases 👶 Source Study
Fusicatenibacter genus Increases 👶 Source Study
Haloferula genus Increases 👶 Source Study
Haloferula genus Increases 👶 Source Study
Herbinix genus Increases 👶 Source Study
Hespellia genus Increases 👶 Source Study
Jejubacter genus Increases 👶 Source Study
Johnsonella genus Increases 👶 Source Study
Kineothrix genus Increases 👶 Source Study
Kluyvera genus Increases 👶 Source Study
Kosakonia genus Increases 👶 Source Study
Lachnoanaerobaculum genus Increases 👶 Source Study
Lachnobacterium genus Increases 👶 Source Study
Lachnoclostridium genus Increases 👶 Source Study
Lachnospira genus Increases 👶 Source Study
Lachnotalea genus Increases 👶 Source Study
Lacrimispora genus Increases 👶 Source Study
Leclercia genus Increases 👶 Source Study
Lelliottia genus Increases 👶 Source Study
Lientehia genus Increases 👶 Source Study
Luteolibacter genus Increases 👶 Source Study
Luteolibacter genus Increases 👶 Source Study
Mangrovibacter genus Increases 👶 Source Study
Marvinbryantia genus Increases 👶 Source Study
Mediterraneibacter genus Increases 👶 Source Study
Merdimonas genus Increases 👶 Source Study
Metakosakonia genus Increases 👶 Source Study
Mobilitalea genus Increases 👶 Source Study
Moryella genus Increases 👶 Source Study
Muricomes genus Increases 👶 Source Study
Murimonas genus Increases 👶 Source Study
Niameybacter genus Increases 👶 Source Study
Novisyntrophococcus genus Increases 👶 Source Study
Oliverpabstia genus Increases 👶 Source Study
Oribacterium genus Increases 👶 Source Study
Parasporobacterium genus Increases 👶 Source Study
Persicirhabdus genus Increases 👶 Source Study
Persicirhabdus genus Increases 👶 Source Study
Phytobacter genus Increases 👶 Source Study
Plesiomonas genus Increases 👶 Source Study
Pluralibacter genus Increases 👶 Source Study
Porcincola genus Increases 👶 Source Study
Prosthecobacter genus Increases 👶 Source Study
Prosthecobacter genus Increases 👶 Source Study
Pseudescherichia genus Increases 👶 Source Study
Pseudobutyrivibrio genus Increases 👶 Source Study
Pseudocitrobacter genus Increases 👶 Source Study
Qiania genus Increases 👶 Source Study
Robinsoniella genus Increases 👶 Source Study
Roseburia genus Increases 👶 Source Study
Roseimicrobium genus Increases 👶 Source Study
Roseimicrobium genus Increases 👶 Source Study
Salmonella genus Increases 👶 Source Study Pathogen
Scandinavium genus Increases 👶 Source Study
Schaedlerella genus Increases 👶 Source Study
Sellimonas genus Increases 👶 Source Study
Shigella genus Increases 👶 Source Study Pathogen
Shimwellia genus Increases 👶 Source Study
Shuttleworthia genus Increases 👶 Source Study
Siccibacter genus Increases 👶 Source Study
Simiaoa genus Increases 👶 Source Study
Sporobacterium genus Increases 👶 Source Study
Sporofaciens genus Increases 👶 Source Study
Stomatobaculum genus Increases 👶 Source Study
Sulfuriroseicoccus genus Increases 👶 Source Study
Sulfuriroseicoccus genus Increases 👶 Source Study
Syntrophococcus genus Increases 👶 Source Study
Trabulsiella genus Increases 👶 Source Study
Tyzzerella genus Increases 👶 Source Study
Verrucomicrobium genus Increases 👶 Source Study
Verrucomicrobium genus Increases 👶 Source Study
Waltera genus Increases 👶 Source Study
Wansuia genus Increases 👶 Source Study
Wujia genus Increases 👶 Source Study
Yokenella genus Increases 👶 Source Study
Biostraticola genus Increases 👶 Source Study
Candidatus Regiella genus Increases 👶 Source Study
Gibbsiella genus Increases 👶 Source Study
Limnobaculum genus Increases 👶 Source Study
Raoultella genus Increases 👶 Source Study
Rosenbergiella genus Increases 👶 Source Study
Enterobacter genus Increases 👪 Source Study Urinary and respiratory infections
Klebsiella genus Increases 👪 Source Study Pathogen
Akkermansia genus Increases 📓 Source Study
Akkermansia genus Increases 📓 Source Study
Enterobacter genus Increases 📓 Source Study Urinary and respiratory infections
Klebsiella genus Increases 📓 Source Study Pathogen
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
Escherichia coli O80:H26 no rank Decreases 👶 Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
Bacillota sensu stricto incertae sedis no rank Decreases 👶 Source Study
environmental samples no rank Decreases 👶 Source Study
unclassified Aeromonas no rank Decreases 👶 Source Study
unclassified Bacillota no rank Decreases 👶 Source Study
unclassified Finegoldia no rank Decreases 👶 Source Study
unclassified Schaalia no rank Decreases 👶 Source Study
Bacteroidetes incertae sedis no rank Increases 👶 Source Study
Enterobacteriaceae incertae sedis no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
environmental samples no rank Increases 👶 Source Study
Klebsiella/Raoultella group no rank Increases 👶 Source Study
Lachnospiraceae incertae sedis no rank Increases 👶 Source Study
unclassified Akkermansia no rank Increases 👶 Source Study
unclassified Akkermansia no rank Increases 👶 Source Study
unclassified Bacteroidota no rank Increases 👶 Source Study
unclassified Enterobacter no rank Increases 👶 Source Study
unclassified Enterobacter cloacae complex no rank Increases 👶 Source Study
unclassified Enterobacteriaceae no rank Increases 👶 Source Study
unclassified Klebsiella no rank Increases 👶 Source Study
unclassified Lachnospiraceae no rank Increases 👶 Source Study
Eggerthellales order Decreases ⚗️ Source Study
unclassified Bacteroidetes Order II. order Increases 👶 Source Study
Eubacteriales order Increases 👪 Source Study
Verrucomicrobiales order Increases 👪 Source Study
Bacillota phylum Decreases 📓 Source Study
Bacteroidota phylum Increases 📓 Source Study Over 70%ile, prone to being fat
Escherichia coli O145 serogroup Decreases 👶 Source Study
Escherichia coli O157 serogroup Decreases 👶 Source Study
Escherichia coli O26 serogroup Decreases 👶 Source Study
Escherichia coli O43 serogroup Decreases 👶 Source Study
Escherichia coli O1:H42 serotype Decreases 👶 Source Study
Escherichia coli O104:H4 serotype Decreases 👶 Source Study
Escherichia coli O121:H19 serotype Decreases 👶 Source Study
Escherichia coli O127:H6 serotype Decreases 👶 Source Study
Escherichia coli O139:H28 serotype Decreases 👶 Source Study
Escherichia coli O157:H7 serotype Decreases 👶 Source Study bloody diarrhea
Escherichia coli O44:H18 serotype Decreases 👶 Source Study
Escherichia coli O55:H7 serotype Decreases 👶 Source Study
Escherichia coli O6:H16 serotype Decreases 👶 Source Study
Escherichia coli O7:K1 serotype Decreases 👶 Source Study
Collinsella aerofaciens species Decreases 📓 Source Study
Blautia obeum species Decreases 📓 Source Study
Clostridioides difficile species Decreases 📓 Source Study Colitis
Bifidobacterium longum species Decreases 📓 Source Study
Akkermansia muciniphila species Decreases 📓 Source Study
Lachnospira eligens species Decreases 📓 Source Study
Dorea formicigenerans species Decreases 📓 Source Study
Escherichia coli species Decreases 📓 Source Study Diarrheal disease in children and travelers, Foodborne diarrhea outbreaks, hemorrhagic colitis, hemolytic-uremic syndrome
Bacteroides caccae species Decreases 📓 Source Study
Bifidobacterium adolescentis species Decreases 📓 Source Study
Ruminococcus bromii species Decreases 📓 Source Study
Fusobacterium nucleatum species Decreases 📓 Source Study Infectious bacteria
Bacteroides thetaiotaomicron species Decreases 📓 Source Study
Thomasclavelia ramosa species Decreases 📓 Source Study
Streptococcus parasanguinis species Decreases 📓 Source Study
Veillonella parvula species Decreases 📓 Source Study
Odoribacter splanchnicus species Decreases 📓 Source Study
Bacteroides xylanisolvens species Decreases 📓 Source Study
Finegoldia sp. S9 AA1-5 species Decreases ⚗️ Source Study
[Ruminococcus] gnavus species Decreases 📓 Source Study
Clostridium perfringens species Decreases 📓 Source Study Food poisoning, gas gangrene
Finegoldia sp. BV3C29 species Decreases 👶 Source Study
Finegoldia sp. MVA6 species Decreases 👶 Source Study
Finegoldia sp. S3MVA9 species Decreases 👶 Source Study
Finegoldia sp. S5-A7 species Decreases 👶 Source Study
Finegoldia sp. S8 F7 species Decreases 👶 Source Study
Finegoldia sp. S9 AA1-5 species Decreases 👶 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Aeromonas allosaccharophila species Decreases 👶 Source Study
Aeromonas bestiarum species Decreases 👶 Source Study
Aeromonas caviae species Decreases 👶 Source Study H01074 Aeromonas infection
Aeromonas dhakensis species Decreases 👶 Source Study
Aeromonas encheleia species Decreases 👶 Source Study
Aeromonas enteropelogenes species Decreases 👶 Source Study
Aeromonas eucrenophila species Decreases 👶 Source Study
Aeromonas hydrophila species Decreases 👶 Source Study Dysenteric gastroenteritis
Aeromonas jandaei species Decreases 👶 Source Study
Aeromonas media species Decreases 👶 Source Study
Aeromonas rivipollensis species Decreases 👶 Source Study
Aeromonas rivuli species Decreases 👶 Source Study
Aeromonas salmonicida species Decreases 👶 Source Study
Aeromonas sanarellii species Decreases 👶 Source Study
Aeromonas schubertii species Decreases 👶 Source Study
Aeromonas simiae species Decreases 👶 Source Study
Aeromonas sobria species Decreases 👶 Source Study
Aeromonas veronii species Decreases 👶 Source Study
Finegoldia magna species Decreases 👶 Source Study Infectious bacteria
Schaalia canis species Decreases 👶 Source Study
Schaalia cardiffensis species Decreases 👶 Source Study
Schaalia funkei species Decreases 👶 Source Study
Schaalia georgiae species Decreases 👶 Source Study
Schaalia hyovaginalis species Decreases 👶 Source Study
Schaalia meyeri species Decreases 👶 Source Study
Schaalia naturae species Decreases 👶 Source Study
Schaalia odontolytica species Decreases 👶 Source Study
Schaalia radingae species Decreases 👶 Source Study
Schaalia suimastitidis species Decreases 👶 Source Study
Schaalia turicensis species Decreases 👶 Source Study
Schaalia vaccimaxillae species Decreases 👶 Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Streptococcus salivarius species Decreases 📓 Source Study Infectious bacteria
Slackia sp. NATTS species Decreases ⚗️ Source Study
Bacteroides uniformis species Decreases 📓 Source Study Infectious bacteria
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Roseburia hominis species Decreases 📓 Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Anaerococcus sp. 8404299 species Decreases ⚗️ Source Study
Bacteroides ovatus species Decreases 📓 Source Study
Lacrimispora saccharolytica species Decreases 📓 Source Study
Bilophila wadsworthia species Decreases 📓 Source Study
Phocaeicola vulgatus species Decreases 📓 Source Study
Akkermansia glycaniphila species Increases 👶 Source Study
Akkermansia glycaniphila species Increases 👶 Source Study
Akkermansia muciniphila species Increases 👶 Source Study
Akkermansia muciniphila species Increases 👶 Source Study
Akkermansia sp. species Increases 👶 Source Study
Akkermansia sp. species Increases 👶 Source Study
Enterobacter asburiae species Increases 👶 Source Study
Enterobacter bugandensis species Increases 👶 Source Study
Enterobacter cancerogenus species Increases 👶 Source Study
Enterobacter chengduensis species Increases 👶 Source Study
Enterobacter cloacae species Increases 👶 Source Study
Enterobacter cloacae complex sp. species Increases 👶 Source Study
Enterobacter hormaechei species Increases 👶 Source Study
Enterobacter huaxiensis species Increases 👶 Source Study
Enterobacter kobei species Increases 👶 Source Study
Enterobacter ludwigii species Increases 👶 Source Study H00300 Enterobacter infection
Enterobacter mori species Increases 👶 Source Study
Enterobacter nickellidurans species Increases 👶 Source Study
Enterobacter oligotrophicus species Increases 👶 Source Study
Enterobacter quasiroggenkampii species Increases 👶 Source Study
Enterobacter roggenkampii species Increases 👶 Source Study H00300 Enterobacter infection
Enterobacter sichuanensis species Increases 👶 Source Study
Enterobacter soli species Increases 👶 Source Study
Enterobacter sp. species Increases 👶 Source Study
Enterobacter sp. ODB01 species Increases 👶 Source Study
Enterobacter sp. PDC34 species Increases 👶 Source Study
Klebsiella aerogenes species Increases 👶 Source Study
Klebsiella africana species Increases 👶 Source Study
Klebsiella granulomatis species Increases 👶 Source Study
Klebsiella grimontii species Increases 👶 Source Study
Klebsiella huaxiensis species Increases 👶 Source Study H00301 Klebsiella infection
Klebsiella michiganensis species Increases 👶 Source Study
Klebsiella oxytoca species Increases 👶 Source Study
Klebsiella pasteurii species Increases 👶 Source Study
Klebsiella pneumoniae species Increases 👶 Source Study H00301 Klebsiella infection, Pneumonia
Klebsiella quasipneumoniae species Increases 👶 Source Study H00301 Klebsiella infection
Klebsiella quasivariicola species Increases 👶 Source Study H00301 Klebsiella infection
Klebsiella sp. E-Nf3 species Increases 👶 Source Study
Klebsiella sp. LTGPAF-6F species Increases 👶 Source Study
Klebsiella variicola species Increases 👶 Source Study
Enterobacter cloacae complex sp. FDA-CDC-AR_0132 species Increases 👶 Source Study
Enterobacter sp. 638 species Increases 👶 Source Study
Enterobacter sp. A7 species Increases 👶 Source Study
Enterobacter sp. Bisph2 species Increases 👶 Source Study
Enterobacter sp. c111(2012) species Increases 👶 Source Study
Enterobacter sp. c112(2012) species Increases 👶 Source Study
Enterobacter sp. E20 species Increases 👶 Source Study
Enterobacter sp. FY-07 species Increases 👶 Source Study
Enterobacter sp. R4-368 species Increases 👶 Source Study
Enterobacter sp. RF-100 species Increases 👶 Source Study
Enterobacter sp. SA187 species Increases 👶 Source Study
Enterobacter sp. SCSS species Increases 👶 Source Study
Klebsiella sp. B12 species Increases 👶 Source Study
Klebsiella sp. FDAARGOS_511 species Increases 👶 Source Study
Klebsiella sp. M5al species Increases 👶 Source Study
Klebsiella sp. OBRC7 species Increases 👶 Source Study
Klebsiella sp. SOR89 species Increases 👶 Source Study
Akkermansia muciniphila species Increases 📓 Source Study
Enterobacter cloacae species Increases 📓 Source Study
Enterobacter mori species Increases 📓 Source Study
Enterobacter sp. BS2-1 species Increases 📓 Source Study
Enterobacter sp. SPSA1 species Increases 📓 Source Study
Enterobacter sp. UDC345 species Increases 📓 Source Study
Klebsiella aerogenes species Increases 📓 Source Study
Enterobacter cloacae complex species group Increases 👶 Source Study
Enterobacter cloacae complex species group Increases 👪 Source Study
Enterobacter cloacae complex species group Increases 📓 Source Study
Akkermansia muciniphila ATCC BAA-835 strain Increases 👶 Source Study
Klebsiella aerogenes EA1509E strain Increases 👶 Source Study H00301 Klebsiella infection
Coriobacterineae suborder Decreases ⚗️ Source Study
Bifidobacterium longum subsp. infantis subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. longum subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. suillum subspecies Decreases 👶 Source Study
Fusobacterium nucleatum subsp. nucleatum subspecies Decreases 👶 Source Study
Enterobacter cloacae subsp. cloacae subspecies Increases 👶 Source Study
Enterobacter cloacae subsp. dissolvens subspecies Increases 👶 Source Study
Chlamydiae/Verrucomicrobia group superphylum Increases ⚗️ Source Study

Impact of melatonin supplement on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0 0
Acne 1.4 1.4 0
ADHD 3.4 1.2 1.83
Age-Related Macular Degeneration and Glaucoma 0.6 0.1 5
Allergic Rhinitis (Hay Fever) 0.5 1.6 -2.2
Allergies 5.2 3.4 0.53
Allergy to milk products 1.6 2.5 -0.56
Alopecia (Hair Loss) 1 0.8 0.25
Alzheimer's disease 3.8 4.3 -0.13
Amyotrophic lateral sclerosis (ALS) Motor Neuron 2.3 4.8 -1.09
Ankylosing spondylitis 3.5 3.4 0.03
Anorexia Nervosa 1.8 1.6 0.13
Antiphospholipid syndrome (APS) 1 0.7 0.43
Asthma 1.4 1.8 -0.29
Atherosclerosis 2.3 0.4 4.75
Atrial fibrillation 2.9 2.4 0.21
Autism 7.4 7.6 -0.03
Barrett esophagus cancer 0.4 0.4 0
benign prostatic hyperplasia 0.2 0.2 0
Bipolar Disorder 1.2 2.3 -0.92
Brain Trauma 0.7 1.4 -1
Breast Cancer 0.2 -0.2
Carcinoma 1.6 1.9 -0.19
Celiac Disease 3.2 3.5 -0.09
Cerebral Palsy 0.9 0.7 0.29
Chronic Fatigue Syndrome 2.9 4.5 -0.55
Chronic Kidney Disease 1.5 1.7 -0.13
Chronic Lyme 0.1 0.7 -6
Chronic Obstructive Pulmonary Disease (COPD) 1.5 0.8 0.88
Chronic Urticaria (Hives) 2 2
Coagulation / Micro clot triggering bacteria 1.9 1.4 0.36
Colorectal Cancer 2.4 3.8 -0.58
Constipation 0.3 1.7 -4.67
Coronary artery disease 2.3 1 1.3
COVID-19 10.4 9.9 0.05
Crohn's Disease 6.7 6.5 0.03
cystic fibrosis 0.6 0.8 -0.33
deep vein thrombosis 1.4 1.3 0.08
Depression 7.6 7 0.09
Dermatomyositis 0.1 2 -19
Eczema 0.4 2.2 -4.5
Endometriosis 2 2 0
Eosinophilic Esophagitis 0.5 1.6 -2.2
Epilepsy 3.3 2.8 0.18
erectile dysfunction 0.8 -0.8
Fibromyalgia 1.2 1.2 0
Functional constipation / chronic idiopathic constipation 2.9 4.6 -0.59
gallstone disease (gsd) 0.7 0.8 -0.14
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.9 1.4 -0.56
Generalized anxiety disorder 1.2 1.7 -0.42
giant cell arteritis 0.1 -0.1
Glioblastoma 0.8 0.1 7
Gout 1.1 0.8 0.38
Graves' disease 2.7 2.4 0.13
Halitosis 0.9 0.4 1.25
Hashimoto's thyroiditis 1.1 2 -0.82
Heart Failure 0.2 0.2
Hidradenitis Suppurativa 1.2 0.7 0.71
Histamine Issues,Mast Cell Issue, DAO Insufficiency 2.1 1.6 0.31
hypercholesterolemia (High Cholesterol) 0.3 0.3 0
hyperglycemia 0.4 1.6 -3
Hyperlipidemia (High Blood Fats) 1.5 1.5 0
hypersomnia 0.5 -0.5
hypertension (High Blood Pressure 4 2.6 0.54
Hypothyroidism 1.4 0.3 3.67
Hypoxia 0.1 0.3 -2
IgA nephropathy (IgAN) 2.9 -2.9
Inflammatory Bowel Disease 5.3 4.2 0.26
Insomnia 0.4 0.9 -1.25
Intelligence 0.2 1 -4
Intracranial aneurysms 0.4 0.7 -0.75
Irritable Bowel Syndrome 4 4.2 -0.05
Juvenile idiopathic arthritis 1.1 -1.1
Liver Cirrhosis 2 4 -1
Long COVID 7.7 11.4 -0.48
Low bone mineral density 0.9 0.4 1.25
Lung Cancer 1.5 0.7 1.14
ME/CFS with IBS 0.2 1.6 -7
ME/CFS without IBS 0.6 0.9 -0.5
Menopause 1.1 1.1
Metabolic Syndrome 7.6 6.8 0.12
Mood Disorders 9.8 8.3 0.18
multiple chemical sensitivity [MCS] 0.4 0.4 0
Multiple Sclerosis 3.8 2.8 0.36
Multiple system atrophy (MSA) 0.5 1 -1
myasthenia gravis 0.6 0.2 2
Neuropathy (all types) 1.5 2 -0.33
neuropsychiatric disorders (PANDAS, PANS) 1.2 1.1 0.09
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 2 3.5 -0.75
NonCeliac Gluten Sensitivity 0.5 0.3 0.67
Obesity 7.1 5.2 0.37
obsessive-compulsive disorder 4.5 2.7 0.67
Osteoarthritis 1 1.3 -0.3
Osteoporosis 1.2 1.7 -0.42
pancreatic cancer 0.3 0.3
Parkinson's Disease 4.1 5.1 -0.24
Polycystic ovary syndrome 0.9 2.3 -1.56
Postural orthostatic tachycardia syndrome 0.3 1.1 -2.67
Premenstrual dysphoric disorder 1.7 0.2 7.5
primary biliary cholangitis 0 1.2 0
Psoriasis 5.3 0.4 12.25
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 4.6 5.8 -0.26
Rosacea 0.7 1.4 -1
Schizophrenia 4.2 4 0.05
scoliosis 1.5 -1.5
sensorineural hearing loss 0.6 0.6
Sjögren syndrome 2.1 1.5 0.4
Sleep Apnea 1.7 1.2 0.42
Small Intestinal Bacterial Overgrowth (SIBO) 0.8 2.5 -2.13
Stress / posttraumatic stress disorder 2.2 2.7 -0.23
Systemic Lupus Erythematosus 3.2 3 0.07
Tic Disorder 0.4 0.7 -0.75
Tourette syndrome 0.4 -0.4
Type 1 Diabetes 1.9 1.9 0
Type 2 Diabetes 6.1 6.4 -0.05
Ulcerative colitis 6.1 3.8 0.61
Unhealthy Ageing 2.7 1.2 1.25

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