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Vaginal Yeast Infections: Tioconazole is commonly used to treat vaginal yeast infections (vulvovaginal candidiasis). It works by disrupting the cell membranes of the fungi, leading to their death. Tioconazole is available in various formulations, including creams, ointments, and suppositories, for intravaginal use.
Skin Infections: Tioconazole may also be prescribed to treat fungal infections of the skin, such as ringworm (tinea corporis) and athlete's foot (tinea pedis). It can be applied topically as a cream or ointment to the affected area.
Nail Infections: In some cases, tioconazole may be used off-label to treat fungal infections of the nails (onychomycosis), although it is not typically the first-line treatment for this condition. Antifungal nail lacquers or systemic antifungal medications are often preferred for treating nail infections.
Effectiveness: Tioconazole is generally effective against a wide range of yeast and fungal species, including Candida albicans, which is the most common cause of vaginal yeast infections. It helps relieve symptoms such as itching, burning, and discharge associated with fungal infections.
Safety: Tioconazole is considered safe for most people when used as directed. However, like all medications, it may cause side effects in some individuals. Common side effects may include local irritation, itching, burning, or redness at the site of application. Rarely, allergic reactions or skin sensitivities may occur.
Usage Instructions: It's essential to follow the instructions provided by your healthcare provider or pharmacist when using tioconazole. The medication is typically applied to the affected area once or twice daily for a specified duration, depending on the severity of the infection and the formulation of the product.
Precautions: Tioconazole is for external use only and should not be ingested. Avoid contact with the eyes, nose, mouth, or other mucous membranes. If accidental ingestion or contact occurs, seek medical attention immediately. Pregnant or breastfeeding individuals should consult their healthcare provider before using tioconazole.
Drug Interactions: Tioconazole may interact with certain medications or topical products. It's essential to inform your healthcare provider about all prescription, over-the-counter, and herbal products you are using before starting treatment with tioconazole.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Akkermansia muciniphila | Reduces |
| species | Bifidobacterium adolescentis | Reduces |
| species | Bifidobacterium longum | Reduces |
| species | Lacticaseibacillus paracasei | Reduces |
| subspecies | Bifidobacterium longum subsp. infantis | Reduces |
| subspecies | Bifidobacterium longum subsp. longum | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Acne | 0.5 | -0.5 | |
| ADHD | 7.1 | 1 | 6.1 |
| Age-Related Macular Degeneration and Glaucoma | 1 | 0.5 | 1 |
| Allergic Rhinitis (Hay Fever) | 2.5 | 2.5 | 0 |
| Allergies | 6.5 | 4.2 | 0.55 |
| Allergy to milk products | 1.5 | 1 | 0.5 |
| Alopecia (Hair Loss) | 2.5 | 2.5 | |
| Alzheimer's disease | 4.2 | 8.7 | -1.07 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 5.1 | 1.3 | 2.92 |
| Ankylosing spondylitis | 4.8 | 2.6 | 0.85 |
| Anorexia Nervosa | 0.5 | 3.5 | -6 |
| Antiphospholipid syndrome (APS) | 2.5 | 2.5 | |
| Asthma | 2 | 2.1 | -0.05 |
| Atherosclerosis | 1.6 | 3.3 | -1.06 |
| Atrial fibrillation | 5.2 | 2.4 | 1.17 |
| Autism | 15 | 13.8 | 0.09 |
| Barrett esophagus cancer | 0.4 | 0.5 | -0.25 |
| Bipolar Disorder | 1.5 | 2.3 | -0.53 |
| Brain Trauma | 1 | 1 | 0 |
| Carcinoma | 4.9 | 3.9 | 0.26 |
| Celiac Disease | 2.7 | 5.6 | -1.07 |
| Cerebral Palsy | 2.2 | 2 | 0.1 |
| Chronic Fatigue Syndrome | 8.7 | 9.7 | -0.11 |
| Chronic Kidney Disease | 3.5 | 3 | 0.17 |
| Chronic Lyme | 1 | -1 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 2.9 | 1.5 | 0.93 |
| Chronic Urticaria (Hives) | 1.3 | 2.7 | -1.08 |
| Coagulation / Micro clot triggering bacteria | 1 | 2 | -1 |
| Colorectal Cancer | 5.3 | 1.5 | 2.53 |
| Constipation | 2 | 1 | 1 |
| Coronary artery disease | 2.5 | 1.3 | 0.92 |
| COVID-19 | 16.6 | 22.5 | -0.36 |
| Crohn's Disease | 10 | 8.9 | 0.12 |
| cystic fibrosis | 1.4 | -1.4 | |
| deep vein thrombosis | 1.5 | -1.5 | |
| Depression | 15.2 | 12.8 | 0.19 |
| Dermatomyositis | 0.5 | 0.5 | 0 |
| Eczema | 1.3 | 3.4 | -1.62 |
| Endometriosis | 3.4 | 1.8 | 0.89 |
| Eosinophilic Esophagitis | 0.2 | 0.3 | -0.5 |
| Epilepsy | 3.9 | 4.1 | -0.05 |
| Fibromyalgia | 4.5 | 4.4 | 0.02 |
| Functional constipation / chronic idiopathic constipation | 7.9 | 6.4 | 0.23 |
| gallstone disease (gsd) | 2.8 | 1.1 | 1.55 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 2.4 | 1.5 | 0.6 |
| Generalized anxiety disorder | 1.7 | 2.9 | -0.71 |
| giant cell arteritis | 0.5 | -0.5 | |
| Glioblastoma | 0.5 | -0.5 | |
| Gout | 0.5 | -0.5 | |
| Graves' disease | 1.9 | 2 | -0.05 |
| Halitosis | 0.9 | 0.5 | 0.8 |
| Hashimoto's thyroiditis | 3.8 | 0.9 | 3.22 |
| Hidradenitis Suppurativa | 0.6 | 0.3 | 1 |
| Histamine Issues,Mast Cell Issue, DAO Insufficiency | 4.4 | 1.5 | 1.93 |
| hypercholesterolemia (High Cholesterol) | 1 | 0.8 | 0.25 |
| hyperglycemia | 3.1 | -3.1 | |
| Hyperlipidemia (High Blood Fats) | 1.4 | 0.5 | 1.8 |
| hypersomnia | 0.5 | -0.5 | |
| hypertension (High Blood Pressure | 3.3 | 7.2 | -1.18 |
| Hypothyroidism | 2 | -2 | |
| Hypoxia | 1.3 | 1.3 | |
| IgA nephropathy (IgAN) | 7 | -7 | |
| Inflammatory Bowel Disease | 6.4 | 13.5 | -1.11 |
| Insomnia | 1.4 | 1.5 | -0.07 |
| Intelligence | 2 | 1 | 1 |
| Intracranial aneurysms | 2 | 0.5 | 3 |
| Irritable Bowel Syndrome | 5.5 | 6.5 | -0.18 |
| Liver Cirrhosis | 6.2 | 4.6 | 0.35 |
| Long COVID | 12.7 | 13 | -0.02 |
| Low bone mineral density | 1.5 | -1.5 | |
| Lung Cancer | 1 | 2.3 | -1.3 |
| ME/CFS with IBS | 2 | 3.9 | -0.95 |
| ME/CFS without IBS | 3.5 | 3.4 | 0.03 |
| Menopause | 3 | 3 | |
| Metabolic Syndrome | 10.9 | 13 | -0.19 |
| Mood Disorders | 19.1 | 13.3 | 0.44 |
| multiple chemical sensitivity [MCS] | 2.2 | 0.5 | 3.4 |
| Multiple Sclerosis | 8.7 | 8.9 | -0.02 |
| Multiple system atrophy (MSA) | 3.1 | 1.5 | 1.07 |
| Neuropathy (all types) | 1.4 | 1.4 | |
| neuropsychiatric disorders (PANDAS, PANS) | 0.5 | 0.5 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 3.5 | 8.2 | -1.34 |
| NonCeliac Gluten Sensitivity | 0.5 | -0.5 | |
| Obesity | 12.8 | 7.6 | 0.68 |
| obsessive-compulsive disorder | 9.2 | 7.2 | 0.28 |
| Osteoarthritis | 3.4 | 0.5 | 5.8 |
| Osteoporosis | 2.2 | 1.7 | 0.29 |
| pancreatic cancer | 1 | 1 | |
| Parkinson's Disease | 4.1 | 5.9 | -0.44 |
| Polycystic ovary syndrome | 3.5 | 3.4 | 0.03 |
| Postural orthostatic tachycardia syndrome | 0.5 | 1 | -1 |
| Premenstrual dysphoric disorder | 1.5 | 0.5 | 2 |
| primary biliary cholangitis | 0.5 | 1.5 | -2 |
| Psoriasis | 6.1 | 4.7 | 0.3 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 9.6 | 5.3 | 0.81 |
| Rosacea | 2 | 1 | 1 |
| Schizophrenia | 10.3 | 3 | 2.43 |
| scoliosis | 0.5 | 1.5 | -2 |
| Sjögren syndrome | 3.9 | 4.9 | -0.26 |
| Sleep Apnea | 2.1 | 2.5 | -0.19 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.6 | 1 | -0.67 |
| Stress / posttraumatic stress disorder | 3.5 | 4.2 | -0.2 |
| Systemic Lupus Erythematosus | 5.8 | 3 | 0.93 |
| Tic Disorder | 2 | 2.7 | -0.35 |
| Tourette syndrome | 0.4 | 0.5 | -0.25 |
| Type 1 Diabetes | 5.2 | 4 | 0.3 |
| Type 2 Diabetes | 11.4 | 10.5 | 0.09 |
| Ulcerative colitis | 3.4 | 8.5 | -1.5 |
| Unhealthy Ageing | 8.6 | 3.4 | 1.53 |
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