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🍽️ dapsone (antibiotic)[CFS]

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  1. Leprosy (Hansen's Disease): Dapsone is a key component of multidrug therapy for the treatment of leprosy. It is effective against Mycobacterium leprae, the bacteria that cause leprosy. Dapsone helps to control the symptoms of leprosy and prevent its spread to others.

  2. Dermatitis Herpetiformis: Dapsone is also used to treat dermatitis herpetiformis, a chronic skin condition characterized by itchy, blistering skin lesions. Dapsone helps to reduce inflammation and suppress the autoimmune response associated with dermatitis herpetiformis.

  3. Other Skin Conditions: Dapsone may be used off-label to treat various other skin conditions, including acne vulgaris, bullous pemphigoid, and linear IgA bullous dermatosis. Its anti-inflammatory and antibacterial properties make it effective in managing these skin disorders.

  4. Pneumocystis Pneumonia (PCP): Dapsone is sometimes used as a prophylactic treatment to prevent Pneumocystis jirovecii pneumonia (formerly known as Pneumocystis carinii pneumonia or PCP) in individuals with weakened immune systems, such as those with HIV/AIDS.

  5. Granulomatous Diseases: Dapsone may be used to treat granulomatous diseases such as granuloma annulare and sarcoidosis. Its anti-inflammatory properties help to suppress granuloma formation and reduce symptoms associated with these conditions.

  6. Adverse Effects: Common side effects of dapsone include nausea, vomiting, headache, dizziness, and skin rash. It can also cause hemolytic anemia, particularly in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Other potential adverse effects include methemoglobinemia, peripheral neuropathy, and liver toxicity.

  7. Monitoring: Patients taking dapsone may require regular monitoring of blood cell counts, liver function tests, and methemoglobin levels to detect and manage potential adverse effects. Close monitoring is especially important in individuals with G6PD deficiency or other risk factors for hemolytic anemia.

  8. Drug Interactions: Dapsone may interact with other medications, including rifampicin, trimethoprim-sulfamethoxazole, and antiretroviral drugs used to treat HIV/AIDS. Healthcare providers should be aware of potential drug interactions and adjust medication doses as needed.

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βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of dapsone (antibiotic)[CFS] On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Akkermansia muciniphila Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium longum Reduces
species Escherichia coli Reduces
species Lacticaseibacillus paracasei Reduces
species Parabacteroides distasonis Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by dapsone (antibiotic)[CFS]

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Akkermansiaceae family Decreases 👪 Source Study
Lachnospira genus Decreases 👪 Source Study
Escherichia genus Decreases 👪 Source Study
Akkermansia genus Decreases 📓 Source Study
Bifidobacterium genus Decreases 👪 Source Study
Bilophila genus Decreases 👪 Source Study High Level Cause Brain Fog(Cognitive impairment)
Blautia genus Decreases 👪 Source Study
Eggerthella genus Decreases 👪 Source Study
Coprococcus genus Decreases 👪 Source Study
Odoribacter genus Decreases 👪 Source Study
Dorea genus Decreases 👪 Source Study
Streptococcus genus Decreases 👪 Source Study
Enterocloster genus Decreases 👪 Source Study
Roseburia genus Decreases 👪 Source Study
Clostridioides genus Decreases 👪 Source Study
Thomasclavelia genus Decreases 👪 Source Study
Bacteroides genus Decreases 👪 Source Study
Veillonella genus Decreases 👪 Source Study
Mediterraneibacter genus Decreases 👪 Source Study
Collinsella genus Decreases 👪 Source Study proinflammatory
Lacticaseibacillus genus Decreases 👪 Source Study
Parabacteroides genus Decreases 👪 Source Study BMI, fat percent,blood pressure
Escherichia coli O1:K1:H7 no rank Decreases 👶 Source Study
Escherichia coli O139:H1 no rank Decreases 👶 Source Study
Escherichia coli O141:H4 no rank Decreases 👶 Source Study
Escherichia coli O145:H34 no rank Decreases 👶 Source Study
Escherichia coli O15:H12 no rank Decreases 👶 Source Study
Escherichia coli O155:H21 no rank Decreases 👶 Source Study
Escherichia coli O158:H23 no rank Decreases 👶 Source Study
Escherichia coli O16:H48 no rank Decreases 👶 Source Study
Escherichia coli O170:H18 no rank Decreases 👶 Source Study
Escherichia coli O18ac:H14 no rank Decreases 👶 Source Study
Escherichia coli O19:H7 no rank Decreases 👶 Source Study
Escherichia coli O2:K1:H4 no rank Decreases 👶 Source Study
Escherichia coli O2:K1:H5 no rank Decreases 👶 Source Study
Escherichia coli O2:K1:H7 no rank Decreases 👶 Source Study
Escherichia coli O20:H12 no rank Decreases 👶 Source Study
Escherichia coli O25:H16 no rank Decreases 👶 Source Study
Escherichia coli O55:H7 no rank Decreases 👶 Source Study
Escherichia coli O68:H12 no rank Decreases 👶 Source Study
Escherichia coli O7:H15 no rank Decreases 👶 Source Study
Escherichia coli O78:H51 no rank Decreases 👶 Source Study
Escherichia coli O80:H26 no rank Decreases 👶 Source Study
Escherichia coli O84:H7 no rank Decreases 👶 Source Study
Escherichia coli O85:H1 no rank Decreases 👶 Source Study
environmental samples no rank Decreases 👶 Source Study
unclassified Akkermansia no rank Decreases 👶 Source Study
Escherichia coli O121 serogroup Decreases 👶 Source Study
Escherichia coli O145 serogroup Decreases 👶 Source Study
Escherichia coli O155 serogroup Decreases 👶 Source Study
Escherichia coli O157 serogroup Decreases 👶 Source Study
Escherichia coli O177 serogroup Decreases 👶 Source Study
Escherichia coli O26 serogroup Decreases 👶 Source Study
Escherichia coli O3 serogroup Decreases 👶 Source Study
Escherichia coli O43 serogroup Decreases 👶 Source Study
Escherichia coli O78 serogroup Decreases 👶 Source Study
Escherichia coli O86 serogroup Decreases 👶 Source Study
Escherichia coli O91 serogroup Decreases 👶 Source Study
Escherichia coli H20 serotype Decreases 👶 Source Study
Escherichia coli O1:H42 serotype Decreases 👶 Source Study
Escherichia coli O1:HNT serotype Decreases 👶 Source Study
Escherichia coli O10:H32 serotype Decreases 👶 Source Study
Escherichia coli O100:H21 serotype Decreases 👶 Source Study
Escherichia coli O103:H2 serotype Decreases 👶 Source Study
Escherichia coli O104:H4 serotype Decreases 👶 Source Study
Escherichia coli O111:H- serotype Decreases 👶 Source Study
Escherichia coli O111:H8 serotype Decreases 👶 Source Study
Escherichia coli O111:NM serotype Decreases 👶 Source Study
Escherichia coli O112ab:H8 serotype Decreases 👶 Source Study
Escherichia coli O112ac:H19 serotype Decreases 👶 Source Study
Escherichia coli O113:H21 serotype Decreases 👶 Source Study
Escherichia coli O114:H49 serotype Decreases 👶 Source Study
Escherichia coli O121:H19 serotype Decreases 👶 Source Study
Escherichia coli O125ac:K+:H10 serotype Decreases 👶 Source Study
Escherichia coli O126:H45 serotype Decreases 👶 Source Study
Escherichia coli O127:H6 serotype Decreases 👶 Source Study
Escherichia coli O128ac:H12 serotype Decreases 👶 Source Study
Escherichia coli O139:H28 serotype Decreases 👶 Source Study
Escherichia coli O145:H25 serotype Decreases 👶 Source Study
Escherichia coli O145:H28 serotype Decreases 👶 Source Study
Escherichia coli O145:NM serotype Decreases 👶 Source Study
Escherichia coli O15:H18 serotype Decreases 👶 Source Study
Escherichia coli O150:H6 serotype Decreases 👶 Source Study
Escherichia coli O152:H23 serotype Decreases 👶 Source Study
Escherichia coli O157:H- serotype Decreases 👶 Source Study
Escherichia coli O157:H43 serotype Decreases 👶 Source Study
Escherichia coli O157:H7 serotype Decreases 👶 Source Study bloody diarrhea
Escherichia coli O16:H6 serotype Decreases 👶 Source Study
Escherichia coli O167:H26 serotype Decreases 👶 Source Study
Escherichia coli O174:H21 serotype Decreases 👶 Source Study
Escherichia coli O176:H45 serotype Decreases 👶 Source Study
Escherichia coli O2:H6 serotype Decreases 👶 Source Study
Escherichia coli O2:K2:H1 serotype Decreases 👶 Source Study
Escherichia coli O25:H1 serotype Decreases 👶 Source Study
Escherichia coli O25:NM serotype Decreases 👶 Source Study
Escherichia coli O26:H11 serotype Decreases 👶 Source Study
Escherichia coli O44:H18 serotype Decreases 👶 Source Study
Escherichia coli O45:H2 serotype Decreases 👶 Source Study
Escherichia coli O6:H16 serotype Decreases 👶 Source Study
Escherichia coli O6:K2:H1 serotype Decreases 👶 Source Study
Escherichia coli O7:H4 serotype Decreases 👶 Source Study
Escherichia coli O7:K1 serotype Decreases 👶 Source Study
Escherichia coli O78:H4 serotype Decreases 👶 Source Study
Escherichia coli O8:H8 serotype Decreases 👶 Source Study
Escherichia coli O89m:H10 serotype Decreases 👶 Source Study
Escherichia coli O89m:H9 serotype Decreases 👶 Source Study
Escherichia coli O9:H10 serotype Decreases 👶 Source Study
Escherichia coli O99:H6 serotype Decreases 👶 Source Study
Lachnospira eligens species Decreases 📓 Source Study
Bifidobacterium longum species Decreases 📓 Source Study
Escherichia coli species Decreases 📓 Source Study Diarrheal disease in children and travelers, Foodborne diarrhea outbreaks, hemorrhagic colitis, hemolytic-uremic syndrome
Akkermansia muciniphila species Decreases 📓 Source Study High Levels linked to long-lived individuals
Bilophila wadsworthia species Decreases 📓 Source Study
Blautia obeum species Decreases 📓 Source Study
Eggerthella lenta species Decreases 📓 Source Study
Coprococcus comes species Decreases 📓 Source Study
Odoribacter splanchnicus species Decreases 📓 Source Study
Dorea formicigenerans species Decreases 📓 Source Study
Streptococcus salivarius species Decreases 📓 Source Study Infectious bacteria
Bifidobacterium adolescentis species Decreases 📓 Source Study
Bacteroides caccae species Decreases 📓 Source Study
Enterocloster bolteae species Decreases 📓 Source Study
Roseburia intestinalis species Decreases 📓 Source Study
Roseburia hominis species Decreases 📓 Source Study
Clostridioides difficile species Decreases 📓 Source Study Colitis
Thomasclavelia ramosa species Decreases 📓 Source Study
Veillonella parvula species Decreases 📓 Source Study
Bacteroides ovatus species Decreases 📓 Source Study
Bacteroides fragilis species Decreases 📓 Source Study H02076 Bacteroides infection
Akkermansia glycaniphila species Decreases 👶 Source Study
Candidatus Akkermansia intestinavium species Decreases 👶 Source Study
[Ruminococcus] torques species Decreases 📓 Source Study
Collinsella aerofaciens species Decreases 📓 Source Study
Lacticaseibacillus paracasei species Decreases 📓 Source Study
Parabacteroides distasonis species Decreases 📓 Source Study
Bifidobacterium longum subsp. infantis subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. longum subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. suillum subspecies Decreases 👶 Source Study
Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases 👶 Source Study
Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases 👶 Source Study

Impact of dapsone (antibiotic)[CFS] on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.2 0.2
Acne 0.2 -0.2
ADHD 1.6 0.4 3
Age-Related Macular Degeneration and Glaucoma 0.3 0 0
Allergic Rhinitis (Hay Fever) 0.4 1.2 -2
Allergies 2.6 0.8 2.25
Allergy to milk products 0.6 0.5 0.2
Alopecia (Hair Loss) 0.5 0.5
Alzheimer's disease 1.6 2.1 -0.31
Amyotrophic lateral sclerosis (ALS) Motor Neuron 2.7 1.1 1.45
Ankylosing spondylitis 1.8 0.5 2.6
Anorexia Nervosa 0 0.8 0
Antiphospholipid syndrome (APS) 0.9 0.2 3.5
Asthma 0.6 1 -0.67
Atherosclerosis 0.3 0.9 -2
Atrial fibrillation 1.5 0.8 0.88
Autism 3.3 4.7 -0.42
Barrett esophagus cancer 0.1 0.2 -1
benign prostatic hyperplasia 0.3 0.3
Biofilm 0.6 0.6
Bipolar Disorder 0.6 0.6 0
Brain Trauma 0.3 0.2 0.5
Cancer (General) 0.2 1.5 -6.5
Carcinoma 1.8 1 0.8
Celiac Disease 1.1 2.5 -1.27
Cerebral Palsy 0.7 0.4 0.75
Chronic Fatigue Syndrome 2.3 3 -0.3
Chronic Kidney Disease 0.7 0.7 0
Chronic Lyme 0.2 -0.2
Chronic Obstructive Pulmonary Disease (COPD) 0.6 0.7 -0.17
Chronic Urticaria (Hives) 1.1 0.6 0.83
Coagulation / Micro clot triggering bacteria 1 0.5 1
Colorectal Cancer 1.9 0.3 5.33
Constipation 0.7 0.3 1.33
Coronary artery disease 0 0.5 0
COVID-19 5 5.5 -0.1
Crohn's Disease 2.9 2.7 0.07
cystic fibrosis 0.8 0.4 1
deep vein thrombosis 0.8 0.3 1.67
Depression 4.3 3.3 0.3
Dermatomyositis 0.2 0.2 0
Eczema 0.4 0.9 -1.25
Endometriosis 1.9 0.6 2.17
Eosinophilic Esophagitis 0.1 -0.1
Epilepsy 1.4 1.3 0.08
Fibromyalgia 0.7 0.7 0
Functional constipation / chronic idiopathic constipation 2.6 1.1 1.36
gallstone disease (gsd) 0.8 0.3 1.67
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.2 0.6 -2
Generalized anxiety disorder 1.1 1.2 -0.09
Glioblastoma 0.2 -0.2
Gout 0.2 -0.2
Graves' disease 0.4 0.5 -0.25
Halitosis 0.2 0.2 0
Hashimoto's thyroiditis 1.2 0.5 1.4
Hidradenitis Suppurativa 0.4 0.1 3
High Histamine/low DAO 0.7 0.2 2.5
hypercholesterolemia (High Cholesterol) 0.2 0.5 -1.5
hyperglycemia 0.4 1.3 -2.25
Hyperlipidemia (High Blood Fats) 0.5 0 0
hypersomnia 0.4 -0.4
hypertension (High Blood Pressure 1.1 2.9 -1.64
Hypothyroidism 0.8 -0.8
Hypoxia 0.4 0.4
IgA nephropathy (IgAN) 1.1 -1.1
Inflammatory Bowel Disease 2.2 3 -0.36
Insomnia 0.5 0.5 0
Intelligence 0.2 0.2
Intracranial aneurysms 0.3 0 0
Irritable Bowel Syndrome 2.1 1.5 0.4
Liver Cirrhosis 2.2 1.5 0.47
Long COVID 3.2 4 -0.25
Low bone mineral density 0.7 -0.7
Lung Cancer 0.6 0.9 -0.5
Mast Cell Issues / mastitis 0.5 0.4 0.25
ME/CFS with IBS 0.5 1.5 -2
ME/CFS without IBS 0.8 0.9 -0.13
Menopause 1.1 1.1
Metabolic Syndrome 3.4 3.8 -0.12
Mood Disorders 5.4 3.5 0.54
multiple chemical sensitivity [MCS] 0.9 0.2 3.5
Multiple Sclerosis 3.5 1.2 1.92
Multiple system atrophy (MSA) 1 0.4 1.5
neuropathic pain 1.1 -1.1
Neuropathy (all types) 0.6 0.3 1
neuropsychiatric disorders (PANDAS, PANS) 0.8 0.8
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.9 3.2 -2.56
NonCeliac Gluten Sensitivity 1.2 0.3 3
Obesity 3.5 2.3 0.52
obsessive-compulsive disorder 2.3 1.7 0.35
Osteoarthritis 0.7 0.7
Osteoporosis 0.6 0.8 -0.33
pancreatic cancer 0.4 0.4
Parkinson's Disease 3.8 2.1 0.81
Polycystic ovary syndrome 0.6 0.8 -0.33
Postural orthostatic tachycardia syndrome 0.4 -0.4
Premenstrual dysphoric disorder 0.5 0 0
primary biliary cholangitis 0.2 0 0
Psoriasis 2.1 0.9 1.33
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 2.6 1.2 1.17
Rosacea 0.3 0.1 2
Schizophrenia 3.2 0.7 3.57
scoliosis 0.2 1 -4
Sjögren syndrome 1.1 1 0.1
Sleep Apnea 0.6 0.8 -0.33
Slow gastric motility / Gastroparesis 0.7 0.2 2.5
Small Intestinal Bacterial Overgrowth (SIBO) 0.7 0.7 0
Stress / posttraumatic stress disorder 1.4 1.6 -0.14
Systemic Lupus Erythematosus 1.7 1.1 0.55
Tic Disorder 0.2 0.5 -1.5
Tourette syndrome 0.3 0.1 2
Type 1 Diabetes 1.3 0.9 0.44
Type 2 Diabetes 3.4 2.9 0.17
Ulcerative colitis 1.8 1.9 -0.06
Unhealthy Ageing 1.6 1 0.6
Vitiligo 0.9 0.9 0

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